Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice
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Psychological stress can have devastating and lasting effects on a variety of behaviors, especially those associated with mental illnesses such as anxiety and depression. Animal models of chronic stress are frequently used to elucidate the mechanisms underlying the relationship between stress and mental health disorders and to develop improved treatment options. The current study expands upon a novel chronic stress paradigm for mice: predatory stress. The predatory stress model incorporates the natural predator-prey relationship that exists among rats and mice and allows for greater interaction between the animals, in turn increasing the extent of the stressful experience. In this study, we evaluated the behavioral effects of exposure to 15 days of predatory stress on an array of behavioral indices. Up to 2 weeks after the end of stress, adult male mice showed an increase of anxiety-like behaviors as measured by the open field and social interaction tests. Animals also expressed an increase in depressive-like behavior in the sucrose preference test. Notably, performance on the novel object recognition task, a memory test, improved after predatory stress. Taken as a whole, our results indicate that 15 exposures to this innovative predatory stress paradigm are sufficient to elicit robust anxiety-like behaviors with evidence of co-morbid depressive-like behavior, as well as changes in cognitive behavior in male mice.
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The general suppressive effects of stress on adult neurogenesis can be largely attributed to the catabolic actions of glucocorticoids, and the reduction in new neuron formation has been associated with impaired cognitive function.
“The general suppressive effects of stress on adult neurogenesis can be largely attributed to the catabolic actions of glucocorticoids and the reduction in new neuron formation has been associated with impaired cognitive function (Bondi et al., 2008; Burgado et al., 2014).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Burgado et al., 2014
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Arıcıoğlu, F., & Leonard, B. E. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_5
How stress, anxiety, and fear affect eating
Carr, J. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29218-7.00006-7
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Differential effects of stress by sex and stress model: the source matters
Carrillo, P. T., Yahel Vidal de la, O., Paz-Trejo, D. B., la Paz, L. D. O.-D., Trujillo-Gutiérrez, N., Sanchez-Flores, F., & Sánchez-Castillo, H. (2026) · Stress · doi:10.1080/10253890.2026.2712384
- Authors
- Burgado, J., Harrell, C. S., Eacret, D., Reddy, R., Barnum, C. J., Tansey, M. G., Miller, A. H., Wang, H., & Neigh, G. N.
- Affiliations
- Emory University (US)
- Corresponding author
- Neigh, Gretchen N.
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 275
- Pages
- 120-125
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC5688846
- OpenAlex
- W2022585706
- Cited by
- 42
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21MH091321)
- National Institute of General Medical Sciences (T32GM008169, R25GM097636)
- National Institute of Environmental Health Sciences (T32ES012870)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- chronic stress, anxiety-like behavior, depression-like behavior, comorbid depression and anxiety, sucrose preference, novel object recognition, memory, social interaction, open field, animal models of stress, male mice
- MeSH terms
- Animals, Anxiety, Depression, Disease Models, Animal, Exploratory Behavior, Food Preferences, Interpersonal Relations, Male, Mice, Inbred C57BL, Predatory Behavior, Stress, Psychological, Sucrose, Sweetening Agents, Time Factors, Maze Learning, Mice
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