Cited by 150Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationPlanarian Biology and Electrostimulation

Budhead,a Fork Head/HNF-3 Homologue, Is Expressed during Axis Formation and Head Specification in Hydra

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Martinez, Daniel E., Dirksen, Marie-Luise, Bode, Patricia M., Jamrich, Milan, Steele, Robert E., Bode, Hans R.·1997·Developmental Biology

Abstract

Accumulating evidence indicates that a common set of genes and mechanisms regulates the developmental processes of a variety of triploblastic organisms despite large variation in their body plans. To what extent these same genes and mechanisms are also conserved among diploblasts, which arose earlier in metazoan evolution, is unclear. We have characterized a hydra homologue of the fork head/HNF-3 class of winged-helix proteins, termed budhead, whose expression patterns suggest a role(s) similar to that found in vertebrates. The vertebrate HNF-3 beta homologues are expressed early in embryogenesis in regions that have organizer properties, and later they have several roles, among them an important role in rostral head formation. In the adult hydra, where axial patterning processes are continuously active, budhead is expressed in the upper part of the head, which has organizer properties. It is also expressed during the formation of a new axis as part of the development of a bud, hydra's asexual form of reproduction. Expression during later stages of budding, during head regeneration and the formation of ectopic heads, indicates a role in head formation. It is likely that budhead plays a critical role in head as well as axis formation in hydra.

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Crossref · 10.1006/dbio.1997.8715

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  • Fox gene expression in Nematostella and Hydra suggests that the mucociliary epithelium around the gastric opening represents the ancient site of activity of the foxA, B, C, D, E superfamily.

    “in Nematostella, foxB [122] and foxA [123] are expressed in the ectodermal ciliated pharynx and foxC [122] in pharyngeal endoderm; in Hydra, foxA/budhead [124] is likewise expressed in the endoderm around the oral opening, suggesting that the mucociliary epithelium around the gastric opening represents the ancient site of activity of the foxA, B, C, D, E superfamily.”

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Authors
Martinez, D. E., Dirksen, M.-L., Bode, P. M., Jamrich, M., Steele, R. E., & Bode, H. R.
Affiliations
  • Center for Biologics Evaluation and Research (US)
  • University of California, Irvine (US)
Venue
Developmental Biology
Publisher
Elsevier BV
Published
1997-12
Volume
192
Issue
2
Pages
523-536
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2083306347
Cited by
150
References
72
Citations by year
2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
14.43
Type
journal article
Language
en
Open access
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Society of Clinical Oncology
  • National Institutes of Health (5p01hd027173-05, 5r01hd008086-22, 5r01rr009755-03)
  • National Center for Research Resources (R01 RR09755)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD08086, P01-HD27173)
Topics
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords
winged helix transcription factor, Hydra, axis formation, budding, head regeneration, evolution of developmental genes
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA-Binding Proteins, Genes, Homeobox, Hydra, Molecular Sequence Data, Morphogenesis, Nuclear Proteins, Phylogeny, Proteins, Regeneration, Reproduction, Asexual, Transcription Factors, Protein Biosynthesis, Sequence Alignment, Sequence Homology, Amino Acid, Gene Expression Regulation, Developmental, Evolution, Molecular, Hepatocyte Nuclear Factor 3-beta

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