The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right Asymmetry
Open accessAbstract
Nodal-related 1 (ndr1) and nodal-related 2 (ndr2) genes in zebrafish encode members of the nodal subgroup of the transforming growth factor-beta superfamily. We report the expression patterns and functional characteristics of these factors, implicating them in the establishment of dorsal-ventral polarity and left-right asymmetry. Ndr1 is expressed maternally, and ndr1 and ndr2 are expressed during blastula stage in the blastoderm margin. During gastrulation, ndr expression subdivides the shield into two domains: a small group of noninvoluting cells, the dorsal forerunner cells, express ndr1, while ndr2 RNA is found in the hypoblast layer of the shield and later in notochord, prechordal plate, and overlying anterior neurectoderm. During somitogenesis, ndr2 is expressed asymmetrically in the lateral plate as are nodal-related genes of other organisms, and in a small domain in the left diencephalon, providing the first observation of asymmetric gene expression in the embryonic forebrain. RNA injections into Xenopus animal caps showed that Ndr1 acts as a mesoderm inducer, whereas Ndr2 is an efficient neural but very inefficient mesoderm inducer. We suggest that Ndr1 has a role in mesoderm induction, while Ndr2 is involved in subsequent specification and patterning of the nervous system and establishment of laterality.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,178
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
SASAI, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,118
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
Turner, D. L., & Weintraub, H. (1994) · Genes & Development · doi:10.1101/gad.8.12.1434 · Cited by 1,019
Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D., & Herrmann, B. G. (1991) · Cell · doi:10.1016/0092-8674(91)90573-h · Cited by 971
über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren
Spemann, H., & Mangold, H. (1924) · Archiv für Mikroskopische Anatomie und Entwicklungsmechanik · doi:10.1007/bf02108176 · Cited by 828
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid
Cho, K. W. Y., Blumberg, B., Steinbeisser, H., & De Robertis, E. M. (1991) · Cell · doi:10.1016/0092-8674(91)90288-a · Cited by 806
A molecular pathway determining left-right asymmetry in chick embryogenesis
Levin, M., Johnson, R. L., Sterna, C. D., Kuehn, M., & Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90477-8 · Cited by 794
Neural Induction by the Secreted Polypeptide Noggin
Lamb, T. M., Knecht, A. K., Smith, W. C., Stachel, S. E., Economides, A. N., Stahl, N., Yancopolous, G. D., & Harland, R. M. (1993) · Science · doi:10.1126/science.8235591 · Cited by 785
Conlon, F. L., Lyons, K. M., Takaesu, N., Barth, K. S., Kispert, A., Herrmann, B., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 770
Cited by
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms
Yeo, C.-Y., & Whitman, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00249-0 · Cited by 377
Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80331-7 · Cited by 374
Thisse, C., & Thisse, B. (1999) · Development · doi:10.1242/dev.126.2.229 · Cited by 316
Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., & Stainier, D. Y. R. (2001) · Genes & Development · doi:10.1101/gad.892301 · Cited by 285
Metadata
- Authors
- Rebagliati, M. R., Toyama, R., Fricke, C., Haffter, P., & Dawid, I. B.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 199
- Issue
- 2
- Pages
- 261-272
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1996551832
- Cited by
- 274
- References
- 68
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right Asymmetry. https://app.cochat.ai/papers/10.1006/dbio.1998.8935
- The paper
- Rebagliati, M. R., Toyama, R., Fricke, C., Haffter, P., & Dawid, I. B. (1998). Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right Asymmetry. Developmental Biology. https://doi.org/10.1006/dbio.1998.8935
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
