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Cited by 55Developmental Biology and Gene RegulationRNA Research and SplicingMicrotubule and mitosis dynamics

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Stable Anterior Anchoring of the Oocyte Nucleus Is Required to Establish Dorsoventral Polarity of the Drosophila Egg

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Guichet, Antoine, Peri, Francesca, Roth, Siegfried·2001·Developmental Biology
DOI 10.1006/dbio.2001.0354
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Abstract

In Drosophila, dorsoventral polarity is established by the asymmetric positioning of the oocyte nucleus. In egg chambers mutant for cap 'n' collar, the oocyte nucleus migrates correctly from a posterior to an anterior-dorsal position where it remains during stage 9 of oogenesis. However, at the end of stage 9, the nucleus leaves its anterior position and migrates towards the posterior pole. The mislocalisation of the nucleus is accompanied by changes in the microtubule network and a failure to maintain bicoid and oskar mRNAs at the anterior and posterior poles, respectively. gurken mRNA associates with the oocyte nucleus in cap 'n' collar mutants and initially the local secretion of Gurken protein activates the Drosophila EGF receptor in the overlying dorsal follicle cells. However, despite the presence of spatially correct Grk signalling during stage 9, eggs laid by cap 'n' collar females lack dorsoventral polarity. cap 'n' collar mutants, therefore, allow for the study of the influence of Grk signal duration on DV patterning in the follicular epithelium.

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  • If the nucleus migrates correctly but later slides back to the posterior pole, as in cnc mutants, the resulting egg chambers completely lack DV polarity.

    “If the nucleus migrates correctly but later slides back to the posterior pole, as in cnc mutants, the resulting egg chambers completely lack DV polarity (figure 4d; Guichet et al. 2001).”

    From The origin of dorsoventral polarity in Drosophila (2003) · cites this paper as Guichet et al. 2001

    The Introduction says that cnc mutant nuclei migrate normally but later slide toward the posterior pole. The section “Cap ’n’ Collar Mutant Eggs Are Ventralised” (page unavailable) reports completely ventralised eggshells in about 80% of cases, not a complete loss of DV polarity in every resulting egg chamber. Figure 7 also shows that dorsal kek1 expression is initially established, though it is not maintained. (LLM, conf=0.88)

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Research works printed but not linked: 54

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Metadata

Authors
Guichet, A., Peri, F., & Roth, S.
Affiliations
University of Cologne (DE)
Corresponding author
Roth, Siegfried
ORCID
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2001-09
Volume
237
Issue
1
Pages
93-106
ISSN
0012-1606 (ISSN-L)
DOI
10.1006/dbio.2001.0354
OpenAlex
W1991733333
Cited by
55
References
0
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2012: 1
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
Deutsche Forschungsgemeinschaft (SFB 243)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
oocyte nucleus, dorsoventral polarity, Drosophila eggs, microtubule cytoskeleton, bicoid mRNA, oskar mRNA, EGF receptor, follicle cells, egg chamber, oogenesis
MeSH terms
Animals, Cell Nucleus, Drosophila, Female, Ovarian Follicle, Oocytes, Oogenesis, RNA, Messenger, Transforming Growth Factors, Transforming Growth Factor alpha, Cell Polarity, Insect Proteins, Drosophila Proteins

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