The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts
Open accessAbstract
We have demonstrated recently that chronic hyperoxic treatment accelerates the rate of aging of fibroblasts and the rate of telomere shortening in parallel. It was hypothesized that accelerated telomere shortening is due to preferential accumulation of oxidative damage in telomeres. To test this hypothesis, we measured the accumulation of sites sensitive to S1 nuclease treatment in telomeres, in minisatellites, and in the bulk of the genome of fibroblasts under different models of oxidative stress as well as after treatment with the alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine. A comparison with qualitative data obtained by alkaline electrophoresis reveals that the sites transferred to double-strand breaks by treatment with low concentrations of S1 nuclease are, in fact, single-stranded regions in the DNA. These regions may resemble single-stranded overhangs, gaps, or conventional single-strand breaks. The frequency of single-stranded regions is significantly higher in telomeres than in minisatellites or in the bulk of the genome under all conditions tested. Those regions induced in minisatellites or in the overall genome by a bolus dose of hydrogen peroxide are completely repaired within 24 h. On the other hand, 50 +/- 12% of H2O2-induced single-stranded regions remain unrepaired for at least 19 days in telomeres of human fibroblasts, leading to a significant increase of the telomeric steady-state level of these lesions. This preferential accumulation might significantly contribute to telomere shortening.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As telomere DNA is particularly sensitive to oxidative damage (Oikawa & Kawanishi, 1999) and single‐strand breaks or other stress‐induced lesions at telomeres are inefficiently repaired (Petersen et al., 1998)”
From P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan (2016) · cites this paper as Petersen et al., 1998
In the citing paper
“single-stranded breaks have been shown to preferentially accumulate at telomeres in conditions of mild oxidative stress, and such lesions lead to replication fork stalling, resulting in incomplete replication of chromosome ends and thus accelerated telomere shortening (Petersen et al., 1998, von Zglinicki, 2000).”
From Telomeres and cell senescence—size matters not (2017) · cites this paper as Petersen et al., 1998
In the citing paper
“Many studies associate the presence of a great amount of mitochondrial ROS with accumulated single-strand breaks in telomere regions, thus accelerating telomere erosion and cellular senescence [106,107].”
From Role of Age-Related Mitochondrial Dysfunction in Sarcopenia (2020) · cites this paper as [106]
Citations
Cites
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Telomere loss: mitotic clock or genetic time bomb?
Harley, C. B. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90018-7 · Cited by 1,139
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106
Makarov, V. L., Hirose, Y., & Langmore, J. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81908-x · Cited by 959
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856
Self-citationOxidative DNA damage and senescence of human diploid fibroblast cells.
Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720
Henderson, E. A., Hardin, C. C., Walk, S. K., Tinoco, I., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90577-0 · Cited by 684
Telomerase activity in normal leukocytes and in hematologic malignancies
Counter, C. M., Gupta, J., Harley, C., Leber, B. F., & Bacchetti, S. (1995) · Blood · doi:10.1182/blood.v85.9.2315.bloodjournal8592315 · Cited by 604
Research works printed but not linked: 1
- von Zglinicki, 1997, Die molekularen Mechanismen der Seneszenz in Zellkultur, Z. Gerontol. Geriatr., 30, 24
Cited by
Sorted by citations
Items 201–300 of 430
Jacczak, B., Rubiś, B., & Totoń, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126381 · Cited by 43
Fretts, A. M., Howard, B. V., Siscovick, D. S., Best, L. G., Beresford, S. A. A., Méte, M., Eilat-Adar, S., Sotoodehnia, N., & Zhao, J. (2016) · Journal of Nutrition · doi:10.3945/jn.116.234922 · Cited by 43
Telomere attrition predicts reduced survival in a wild social bird, but short telomeres do not
Wood, E. M., & Young, A. J. (2019) · Molecular Ecology · doi:10.1111/mec.15181 · Cited by 40
Organophosphate insecticide exposure and telomere length in U.S. adults
Ock, J., Kim, J., & Choi, Y. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135990 · Cited by 41
Telomere shortening in leukocyte subpopulations from baboons
Baerlocher, G. M., Mak, J., Röth, A., Rice, K. S., & Lansdorp, P. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0702361 · Cited by 42
Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 41
Mechanisms of telomeric instability
Baird, D. M. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167817 · Cited by 40
Lack of Poly(ADP-Ribose) Polymerase-1 Gene Product Enhances Cellular Sensitivity to Arsenite
Poonepalli, A., Balakrishnan, L., Khaw, A. K., Low, G. K. M., Jayapal, M., Bhattacharjee, R. N., Akira, S., Balajee, A. S., & Hande, M. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2336 · Cited by 38
Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology
Toussaint, O., Weemaels, G., Debacq‐Chainiaux, F., Scharffetter‐Kochanek, K., & Wlaschek, M. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22416 · Cited by 38
Larsen, S. A., Kassem, M. S., & Rattan, S. I. S. (2012) · Chemistry Central Journal · doi:10.1186/1752-153x-6-18 · Cited by 38
Ma, W., Panduri, V., Sterling, J. F., Houten, B. V., Gordenin, D. A., & Resnick, M. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01499-08 · Cited by 38
Wolf, N. S., & Pendergrass, W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b502 · Cited by 37
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric‐3′‐overhang
Keys, B., Serra, V., Saretzki, G. C., & von Zglinicki, T. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00094.x · Cited by 38
Self-citationCellular Senescence in Telomerase-Expressing Syrian Hamster Embryo Cells
Carman, T. A., Afshari, C. A., & Barrett, J. C. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4207 · Cited by 38
Accelerated Aging during Chronic Oxidative Stress: A Role for PARP-1
Boesten, D. M. P. H. J., de Vos-Houben, J. M. J., Timmermans, L., den Hartog, G. J. M., Bast, A., & Hageman, G. J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/680414 · Cited by 37
Hoffmann, J., & Spyridopoulos, I. (2011) · Future Cardiology · doi:10.2217/fca.11.55 · Cited by 36
Telomere length in Chernobyl accident recovery workers in the late period after the disaster
Reste, J., Zvigule, G., Zvagule, T., Kurjāne, N., Eglīte, M., Gabruševa, N., Bērziņa, D., Plonis, J., & Miklaševičs, E. (2014) · Journal of Radiation Research · doi:10.1093/jrr/rru060 · Cited by 41
Aging and the programmed death phenomena
Skulachev, V. P. (2003) · Topics in current genetics · doi:10.1007/978-3-540-37005-5_8 · Cited by 36
Coluzzi, E., Buonsante, R., Leone, S., Asmar, A. J., Miller, K. L., Cimini, D., & Sgura, A. (2017) · Scientific Reports · doi:10.1038/srep43309 · Cited by 37
Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C
Stout, G. J., & Blasco, M. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3125 · Cited by 35
Telomere length shortening in patients with dementia with Lewy bodies
Kume, K., Kikukawa, M., Hanyu, H., Takata, Y., Umahara, T., Sakurai, H., Kanetaka, H., Ohyashiki, K., Ohyashiki, J. H., & Iwamoto, T. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03655.x · Cited by 36
Hong, X., Wang, L., Zhang, K., Liu, J., & Liu, J. (2022) · Cells · doi:10.3390/cells11050877 · Cited by 37
Telomere length, antioxidant status and incidence of ischaemic heart disease in type 2 diabetes
Masi, S., D’Aiuto, F., Cooper, J. A., Salpea, K. D., Stephens, J. W., Hurel, S. J., Deanfield, J. E., & Humphries, S. E. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.04.130 · Cited by 36
Epigenetic aspects of cellular senescence
Young, J. I., & Smith, J. R. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00076-5 · Cited by 35
OECD Series on Adverse Outcome Pathways
OECD (2016) · OECD series on adverse outcome pathways · doi:10.1787/2415170x · Cited by 36
Baek, J. H., Son, H., Jeong, Y., Park, S. W., & Kim, H. J. (2019) · Cells · doi:10.3390/cells8030247 · Cited by 37
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
Ji, Y., Dang, X., Nguyen, L. N. T., Nguyen, L. N., Zhao, J., Cao, D., Khanal, S., Schank, M., Wu, X. Y., Morrison, Z. D., et al. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0153-z · Cited by 36
Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder
Lundberg, M., Millischer, V., Backlund, L., Martinsson, L., Stenvinkel, P., Sellgren, C. M., Lavebratt, C., & Schalling, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.586083 · Cited by 38
Hovest, M. G., Brüggenolte, N., Shah‐Hosseini, K., Krieg, T. M., & Herrmann, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0701 · Cited by 35
Low oxygen delays fibroblast senescence despite shorter telomeres
Betts, D. H., Perrault, S. D., & King, W. A. (2007) · Biogerontology · doi:10.1007/s10522-007-9113-7 · Cited by 34
TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection
Marinaccio, J., Micheli, E., Udroiu, I., Nottia, M. D., Carrozzo, R., Baranzini, N., Grimaldi, A., Leone, S., Moreno, S., Muzzi, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054450 · Cited by 35
Nguyen, L. N., Zhao, J., Cao, D., Dang, X., Wang, L., Lian, J., Zhang, Y., Jia, Z., Wu, X. Y., Morrison, Z. D., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0897-y · Cited by 34
Dang, X., Ogbu, S. C., Zhao, J., Nguyen, L. N. T., Cao, D., Nguyen, L. N., Khanal, S., Schank, M., Thakuri, B. K. C., Wu, X. Y., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2395-2 · Cited by 32
Ishaq, A., Tchkonia, T., Kirkland, J. L., Siervo, M., & Saretzki, G. C. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111798 · Cited by 33
Self-citationStraface, E., Vona, R., Ascione, B., Matarrese, P., Strudthoff, T., Franconi, F., & Malorni, W. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.006 · Cited by 32
Telomeres: beacons of autocrine and paracrine DNA damage during skin aging
Victorelli, S. G., & Passos, J. F. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1728016 · Cited by 35
Yang, L., Sun, L., Teng, Y., Chen, H., Gao, Y. D., Levine, A. S., Nakajima, S., & Lan, L. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx083 · Cited by 31
Human fibroblasts in vitro senesce with a donor‐specific telomere length
Serra, V., & von Zglinicki, T. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02504-8 · Cited by 31
Self-citationZhao, Y., Wang, J., Xu, L., Xu, H., Yan, Y., Zhao, H., & Yan, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13061443 · Cited by 36
Cheng, S., Davis, S., & Sharma, S. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12851 · Cited by 31
Rapid telomere attrition in cardiac tissue of the ageing Wistar rat
Hastings, R., Li, N.-C., Lacy, P. S., Patel, H. V., Herbert, K. E., Stanley, A. G., & Williams, B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.02.003 · Cited by 31
Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver
Lebel, M., de Souza-Pinto, N. C., & Bohr, V. A. (2011) · Current Gerontology and Geriatrics Research · doi:10.1155/2011/859415 · Cited by 31
Richardson, G. D., Sage, A., Bennaceur, K., Zhrany, N. A., Coelho‐Lima, J., Dookun, E., Draganova, L., Saretzki, G. C., Breault, D. T., Mallat, Z., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309940 · Cited by 29
Self-citationMontali, I., Berti, C. C., Morselli, M., Acerbi, G., Barili, V., Pedrazzi, G., Montanini, B., Boni, C., Alfieri, A., Pesci, M., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.035 · Cited by 30
Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress
Harbo, M., Kølvraa, S., Serakıncı, N., & Bendix, L. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.06.003 · Cited by 30
Functions of ADP-ribose transferases in the maintenance of telomere integrity
Muoio, D., Laspata, N., & Fouquerel, E. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04235-z · Cited by 34
Telomere Attrition in Chronic Kidney Diseases
Levstek, T., & Podkrajšek, K. T. (2023) · Antioxidants · doi:10.3390/antiox12030579 · Cited by 29
Stn1 is critical for telomere maintenance and long‐term viability of somatic human cells
Boccardi, V., Razdan, N., Kaplunov, J. M., Mundra, J. J., Kimura, M., Aviv, A., & Herbig, U. (2015) · Aging Cell · doi:10.1111/acel.12289 · Cited by 27
Stochastic modeling of length-dependent telomere shortening in Corvus monedula
Grasman, J., Salomons, H. M., & Verhulst, S. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.04.026 · Cited by 30
Telomeres and Telomerase Activity in Scleractinian Corals and Symbiodinium spp.
Zielke, S., & Bodnar, A. G. (2010) · Biological Bulletin · doi:10.1086/bblv218n2p113 · Cited by 28
DNA damage-dependent mechanisms of ageing and disease in the macro- and microvasculature
Shah, A. V., & Bennett, M. R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.050 · Cited by 27
X-ray-induced telomeric instability in Atm-deficient mouse cells
Barkhaa, U., Kodama, S., Suzuki, K., Niwa, O., & Watanabe, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.014 · Cited by 28
Thosar, S. A., Barnes, R. P., Detwiler, A. C., Bhargava, R., Wondisford, A. R., O’Sullivan, R. J., & Opresko, P. L. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113656 · Cited by 30
Genome Integrity Is Regulated by the Caenorhabditis elegans Rad51D Homolog rfs-1
Yanowitz, J. L. (2008) · Genetics · doi:10.1534/genetics.107.076877 · Cited by 27
Cross, J. A., Brennan, C., Gray, T., Temple, R., Dozio, N., Hughes, J. C., Levell, N. J., Murphy, H. R., Fowler, D., Hughes, D. A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1207-5 · Cited by 26
Armstrong, L., Lako, M., van Herpe, I., Evans, J., Saretzki, G. C., & Hole, N. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.07.005 · Cited by 26
Self-citationSalpea, K. D., Maubaret, C. G., Kathagen, A., Ken‐Dror, G., Gilroy, D. W., & Humphries, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073756 · Cited by 25
Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
Mark, A. B. (2010) · Frontiers in bioscience · doi:10.2741/3655 · Cited by 26
Genetic and environmental factors influencing human diseases with telomere dysfunction.
Ly, H. (2009) · PubMed · Cited by 25
Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells
McCaul, J. A., Gordon, K., Minty, F., Fleming, J., & Parkinson, E. K. (2007) · Oral Oncology · doi:10.1016/j.oraloncology.2007.02.010 · Cited by 25
Telomeres and endocrine dysfunction of the adrenal and GH / IGF ‐1 axes
Aulinas, A., Barahona, M. J., Barahona, M. J., Mato, E., Bell, O. L., Surrallés, J., & Webb, S. M. (2013) · Clinical Endocrinology · doi:10.1111/cen.12310 · Cited by 26
Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status
Vahter, M., Bröberg, K., & Harari, F. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa198 · Cited by 25
Effect of oxidative stress on telomere maintenance in aortic smooth muscle cells
Gordon, C.-A., Madamanchi, N. R., Runge, M. S., & Jarstfer, M. B. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166397 · Cited by 24
Ricoul, M., Gnanasekaran, T. S., Brochard, P., Hérate, C., & Sabatier, L. (2019) · Cancers · doi:10.3390/cancers11091397 · Cited by 24
Telomeres, cell senescence and human ageing
von Zglinicki, T., Martin-Ruiz, C. M., & Saretzki, G. C. (2005) · Signal Transduction · doi:10.1002/sita.200400049 · Cited by 23
Self-citationImplication of asana, pranayama and meditation on telomere stability
Abraham, J., & Rathore, M. (2018) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_51_17 · Cited by 23
Zhu, H., Manson, J. E., Cook, N. R., Bekele, B. B., Chen, L., Kane, K., Huang, Y., Li, W., Christen, W., Lee, I.-M. M., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.05.003 · Cited by 28
Genomic Instability in Newborn with Short Telomeres
Moreno-Palomo, J., Creus, A., Marcos, R., & Hernández, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091753 · Cited by 22
Pollicita, M., Muscoli, C., Sgura, A., Biasin, A., Granato, T., Masuelli, L., Mollace, V., Tanzarella, C., Duca, C. D., Rodinò, P., et al. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-51 · Cited by 23
Liu, D.-Y. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i8.1859 · Cited by 22
Urushibara, A., Kodama, S., Suzuki, K., Desa, M. B. M., Suzuki, F., Tsutsui, T., & Watanabe, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.039 · Cited by 22
Hwang, W.-S., Park, S.-H., Kim, H.-S., Kang, H.-J., Kim, M.-J., Oh, S.-J., Park, J.-B., Kim, J., Kim, S. C., & Lee, J.-Y. (2007) · Nutrition Research and Practice · doi:10.4162/nrp.2007.1.2.105 · Cited by 21
Desgarnier, M. D., Zinflou, C., Mallet, J. D., Gendron, S. P., Méthot, S. J., & Rochette, P. J. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19878 · Cited by 23
Błasiak, J., Szczepańska, J., Fila, M., Pawłowska, E., & Kaarniranta, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137194 · Cited by 22
Ambient air pollution exposure and telomere length: a systematic review and meta-analysis
Zong, Z.-Q., Sw, C., Wu, Y., Gui, S.-Y., Zhang, X.-J., & Hu, C.-Y. (2023) · Public Health · doi:10.1016/j.puhe.2022.11.022 · Cited by 21
Muoio, D., Laspata, N., Dannenberg, R. L., Curry, C., Darkoa-Larbi, S., Hedglin, M., Uttam, S., & Fouquerel, E. (2024) · Nature Communications · doi:10.1038/s41467-024-47222-7 · Cited by 20
DNA damage susceptibility and repair in correlation to calendric age and longevity
Zahn, R. K., Zahn-Daimler, G., Ax, S., Reifferscheid, G., Waldmann, P., Fujisawa, H., & Hosokawa, M. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00170-6 · Cited by 21
Saretzki, G. C., & von Zglinicki, T. (1999) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910050086 · Cited by 20
Self-citationBirth and death: Evidence for the same biologic clock
Phillippe, M., & Phillippe, S. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12638 · Cited by 18
Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis
Lü, J., Vallabhaneni, H., Yin, J., & Liu, Y. (2013) · Aging Cell · doi:10.1111/acel.12085 · Cited by 19
Shorter telomeres in children with severe asthma, an indicative of accelerated aging
Barbé‐Tuana, F. M., Grün, L. K., Pierdoná, V., Parisi, M. M., Friedrich, F., Guma, F. T. C. R., Pinto, L. A., Stein, R. T., Pitrez, P. M., & Jones, M. H. (2021) · Aging · doi:10.18632/aging.202527 · Cited by 19
Measuring Reactive Oxygen Species in Senescent Cells
Passos, J. F., Miwa, S., & von Zglinicki, T. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_17 · Cited by 18
Self-citationTing, A. P. L., Low, G. K. M., Gopalakrishnan, K., & Hande, M. P. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00945.x · Cited by 18
Fan, R., Olbricht, G. R., Baker, X., & Hou, C. (2016) · Aging · doi:10.18632/aging.101081 · Cited by 18
Telomere Length as a Biomarker of Biological Aging in Shift Workers
Ledda, C., Loreto, C., & Rapisarda, V. (2020) · Applied Sciences · doi:10.3390/app10082764 · Cited by 17
Holliday Junctions Formed from Human Telomeric DNA
Haider, S. M., Li, P., Khiali, S., Munnur, D., Ramanathan, A., & Parkinson, G. N. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08699 · Cited by 17
Matuoka, K., & Chen, K. Y. (2002) · Biogerontology · doi:10.1023/a:1021324017008 · Cited by 17
Baltzis, D., Meimeti, E., Grammatikopoulou, M. G., Roustit, M., Mavrogonatou, E., Kletsas, D., Efraimidou, S., Manes, C., Νikolouzakis, Τ. Κ., Tsiaoussis, J., et al. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5798 · Cited by 17
Helicobacter pylori eradication increases telomere length in gastric mucosa.
Aslan, R., Bektaş, A., Bedir, A., Alaçam, H., Aslan, M. S., Nar, R., Yıldırım, B., GÖREN, İ., Ecemiş, Ö., Ustaoğlu, M., et al. (2013) · PubMed · doi:10.5754/hge12691 · Cited by 16
The telomere gestational clock: increasing short telomeres at term in the mouse
Phillippe, M., Sawyer, M. R., & Edelson, P. K. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.01.218 · Cited by 15
Habib, R., Kim, R., Neitzel, H., Demuth, I., Chrzańowska, K., Seemanová, E., Faber, R., Digweed, M., Voß, R., Jäger, K., et al. (2020) · Aging · doi:10.18632/aging.103453 · Cited by 16
X-rays Activate Telomeric Homologous Recombination Mediated Repair in Primary Cells
de Vitis, M., Berardinelli, F., Coluzzi, E., Marinaccio, J., O’Sullivan, R. J., & Sgura, A. (2019) · Cells · doi:10.3390/cells8070708 · Cited by 16
Telomere dysfunction in chronic liver disease: The link from aging
Penrice, D. D., Jalan‐Sakrikar, N., Jurk, D., Passos, J. F., & Simonetto, D. A. (2023) · Hepatology · doi:10.1097/hep.0000000000000426 · Cited by 14
Telomere Q-PNA-FISH - Reliable Results from Stochastic Signals
Ćukušić, A., Vidaček, N. Š., Huzak, M., Ivanković, M., & Rubelj, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092559 · Cited by 16
The relationship between telomere length and beekeeping among Malaysians
Nasir, N. F. M., Kannan, T. P., Sulaiman, S. A., Shamsuddin, S., Azlina, A., & Stângaciu, Ş. (2015) · AGE · doi:10.1007/s11357-015-9797-6 · Cited by 14
Senescent Cells: Dual Implications on the Retinal Vascular System
Habibi-Kavashkohie, M. R., Scorza, T., & Oubaha, M. (2023) · Cells · doi:10.3390/cells12192341 · Cited by 12
Breaking the aging epigenetic barrier
Sikder, S., Arunkumar, G., Melters, D. P., & Dalal, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.943519 · Cited by 12
Mutation frequency analysis of mononucleotide and dinucleotide repeats after oxidative stress
Yamada, N. A., Parker, J. M., & Farber, R. A. (2003) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10179 · Cited by 12
Senescent Accelerated Mouse (SAM): A Model that Binds In Vivo and In Vitro Aging
Yegorov, Y. E., Semenova, I. V., Karachentsev, D., Semenova, М. L., Akimov, S. S., Yegorova, I. N., & Zelenin, A. V. (2001) · Rejuvenation Research · doi:10.1089/109454501750225677 · Cited by 12
Giorgio, M., Stendardo, M., Migliaccio, E., & Pelicci, P. G. (2016) · Aging Cell · doi:10.1111/acel.12448 · Cited by 11
“…particularly sensitive to oxidative damage (Oikawa & Kawanishi, 1999) and single-strand breaks or other stress-induced lesions at telomeres are inefficiently repaired (Petersen et al., 1998), oxidative stress is considered to accelerate telomere erosion (von Zglinicki, 2002; Houben et al., 2008).”
Background
Metadata
- Authors
- Petersen, S., Saretzki, G., & Zglinicki, T. V.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Zglinicki, Thomas von
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 239
- Issue
- 1
- Pages
- 152-160
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2037480531
- Cited by
- 427
- References
- 33
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 15 · 2021: 14 · 2020: 14 · 2019: 19 · 2018: 18 · 2017: 14 · 2016: 23 · 2015: 15 · 2014: 16 · 2013: 17 · 2012: 20
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomeres, telomere shortening, oxidative DNA damage, hydrogen peroxide, S1 nuclease, minisatellites, N-methyl-N'-nitro-N-nitrosoguanidine, alkylating agents, DNA repair, human fibroblasts, hyperoxia, aging
- MeSH terms
- Cell Line, DNA, Fibroblasts, Humans, Methylnitronitrosoguanidine, Single-Strand Specific DNA and RNA Endonucleases, Telomere, Minisatellite Repeats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review