Endogenous β-Galactosidase Activity in Continuously Nonproliferating Cells
Abstract
Cytochemically detectable activity of endogenous beta-galactosidase was found at pH 6.0 in Swiss 3T3 cells after long-term incubation in low serum or in the presence of heparin concentrations known to reversibly inhibit cell proliferation. A high percentage of beta-galactosidase-positive cells were detected in U937 and HL60 cultures at the late stage of macrophage-like differentiation induced by TPA. Interestingly, a small number of beta-galactosidase-positive cells were found even in the growing Swiss 3T3 cultures. These positive cells expressed morphological features similar to those of senescent cells. Thus, the activity of beta-galactosidase at pH 6.0 cannot be considered an exclusive marker of senescent cells since it is expressed in other types of nonproliferating cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Non-senescent macrophages may exhibit SA-β-gal positivity, and microglia can also stain positive in non-senescent contexts due to their phagocytic function and possible associated change in lysosomal numbers.
“In particular, non-senescent macrophages may exhibit SA-β-gal positivity [145,146], and microglia can also stain positive in non-senescent contexts due to their phagocytic function and the possible associated change in lysosomal numbers [147].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [147]
Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Rovera, G., Santoli, D., & Damsky, C. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.6.2779 · Cited by 1,005 · see citing works
Genetic analysis of ageing: role of oxidative damage and environmental stresses
Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 641 · see citing works
Human skin fibroblasts in vitro differentiate along a terminal cell lineage.
Bayreuther, K., Rodemann, H. P., Hommel, R., Dittmann, K., Albiez, M., & Francz, P. I. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5112 · Cited by 396 · see citing works
Hill, P. A., Reynolds, J. J., & Meikle, M. C. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828521 · Cited by 157 · see citing works
Watanabe, Y., Lee, S. W., Detmar, M. J., Ajioka, I., & Dvorak, H. F. (1997) · Oncogene · doi:10.1038/sj.onc.1201033 · Cited by 141 · see citing works
(1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90250-a · Cited by 135 · see citing works
Nature and the Multiple Functions of the 67-kD Elastin-/Laminin Binding Protein
Hinek, A. (1994) · Cell Communication & Adhesion · doi:10.3109/15419069409004436 · Cited by 96 · see citing works
Molecular and Cell Biology of Replicative SenescencePreprint
Dimri, G. P., & Campisi, J. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.010 · Cited by 93 · see citing works
(1980) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)x7007-x · Cited by 77 · see citing works
Ladoux, A., Cragoe, E. J., Geny, B., Abita, J., & Frelin, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75858-x · Cited by 54 · see citing works
Wieser, R. J., Heck, R., & Oesch, F. (1985) · Experimental Cell Research · doi:10.1016/0014-4827(85)90472-0 · Cited by 43 · see citing works
Oshima, A., Yoshida, K., Itoh, K., Kase, R., Sakuraba, H., & Suzuki, Y. (1994) · Human Genetics · doi:10.1007/bf00210592 · Cited by 36 · see citing works
Bidirectional Regulation of Telomerase Activity in a Subline Derived from Human Lung Adenocarcinoma
Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S., & Shirahata, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7104 · Cited by 23 · see citing works
Wieser, R. J., & Oesch, F. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90122-x · Cited by 21 · see citing works
Presence of lysosomal enzymes in the normal glomerular basement membrane matrix
Singh, A. K. (1993) · The Histochemical Journal · doi:10.1007/bf00173054 · Cited by 12 · see citing works
Presence of lysosomal enzymes in the normal glomerular basement membrane matrix
Singh, A. K. (1993) · The Histochemical Journal · doi:10.1007/bf02388064 · Cited by 11 · see citing works
Solavagione, E. (1987) · Biochimie · doi:10.1016/0300-9084(87)90048-4 · Cited by 6 · see citing works
[Heparin slows proliferation of human diploid fibroblasts in two periods of the cell cycle].
Fedorov, I. V., Egorov, E. E., & Av, Z. (1994) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Senescence-associated β-galactosidase is lysosomal β-galactosidase.
Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works
Kurz, D. J., Decary, S., Hong, Y., & Erusalimsky, J. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3613 · Cited by 899 · see citing works
Resurrection of endogenous retroviruses during aging reinforces senescence
Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390 · see citing works
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works
Cellular senescence and organismal aging
Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 347 · see citing works
Cigarette smoke induces cellular senescence
Nyunoya, T., Monick, M. M., Klingelhutz, A., Yarovinsky, T. O., Cagley, J. R., & Hunninghake, G. W. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0169oc · Cited by 306 · see citing works
YANG, N., & HU, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.011 · Cited by 245 · see citing works
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.03.008 · Cited by 195 · see citing works
A comparative analysis of the cell biology of senescence and aging
Hwang, E. S., Yoon, G., & Kang, H. T. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0034-2 · Cited by 192 · see citing works
Leontieva, O. V., Demidenko, Z. N., & Blagosklonny, M. V. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405723111 · Cited by 150 · see citing works
The short-lived African turquoise killifish: an emerging experimental model for ageing
Kim, Y., Nam, H. G., & Valenzano, D. R. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.023226 · Cited by 139 · see citing works
Mandel, K., Yang, Y., Schambach, A., Glage, S., Otte, A., & Hass, R. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0249 · Cited by 134 · see citing works
Self-citationMesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment
Hass, R., & Otte, A. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-26 · Cited by 126 · see citing works
Self-citationde Mera‐Rodríguez, J. A., Álvarez‐Hernán, G., Gañán, Y., Martín‐Partido, G., Rodríguez‐León, J., & Francisco‐Morcillo, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.623175 · Cited by 123 · see citing works
Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions
Jha, S. K., Rubis, G. D., Devkota, S. R., Zhang, Y., Adhikari, R., Jha, L. A., Bhattacharya, K., Mehndiratta, S., Gupta, G., Singh, S. K., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102315 · Cited by 122 · see citing works
Differentiation between Senescence (M1) and Crisis (M2) in Human Fibroblast Cultures
Wei, W., & Sedivy, J. M. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4665 · Cited by 109 · see citing works
The relationship between aging and carcinogenesis: a critical appraisal
Anisimov, V. N. (2003) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(02)00121-x · Cited by 94 · see citing works
Basic Methods of Cell Cycle Analysis
Ligasová, A., Frydrych, I., & Koberna, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043674 · Cited by 92 · see citing works
Premature cellular senescence induced by pyocyanin, a redox-active Pseudomonas aeruginosa toxin
Müller, M. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.004 · Cited by 90 · see citing works
Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.
Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., & Hara, E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.006 · Cited by 84 · see citing works
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
Mansfield, L., Ramponi, V., Gupta, K., Stevenson, T., Mathew, A. B., Barinda, A. J., Herbstein, F., & Morsli, S. (2024) · npj Aging · doi:10.1038/s41514-024-00181-1 · Cited by 91 · see citing works
Tsai, S. B., Tucci, V., Uchiyama, J., Fabian, N. J., Lin, M. C., Bayliss, P. E., Neuberg, D. S., Zhdanova, I. V., & Kishi, S. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00278.x · Cited by 83 · see citing works
α-Fucosidase as a novel convenient biomarker for cellular senescence
Hildebrand, D. G., Lehle, S., Borst, A., Haferkamp, S., Eßmann, F., & Schulze‐Osthoff, K. (2013) · Cell Cycle · doi:10.4161/cc.24944 · Cited by 79 · see citing works
The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal
Ashraf, H. M., Fernandez, B., & Spencer, S. L. (2023) · Nature Communications · doi:10.1038/s41467-023-40132-0 · Cited by 74 · see citing works
Muthamil, S., Kim, H., Jang, H., Lyu, J., Shin, U. C., Go, Y., Park, S., Lee, H. G., & Park, J. H. (2024) · Advanced Biology · doi:10.1002/adbi.202400079 · Cited by 79 · see citing works
Cellular senescence: a hitchhiker’s guide
Aravinthan, A. D. (2015) · Human Cell · doi:10.1007/s13577-015-0110-x · Cited by 73 · see citing works
Does pH 6 β-galactosidase activity indicate cell senescence?
Krishna, D. R., Sperker, B., Fritz, P., & Klotz, U. E. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00031-7 · Cited by 73 · see citing works
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Ng, P. Y., McNeely, T. L., & Baker, D. J. (2023) · The FEBS Journal · doi:10.1111/febs.16315 · Cited by 68 · see citing works
Mesenchymal Stem Cells Maintain Long-Term In Vitro Stemness During Explant Culture
Otte, A., Bucan, V., Reimers, K., & Hass, R. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0007 · Cited by 66 · see citing works
Self-citationIn Vitro Replication and Differentiation of Normal Human Oral Keratinocytes
Kang, M., Bibb, C. A., Baluda, M. A., Rey, O., & Park, N.-H. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4943 · Cited by 64 · see citing works
Maier, A. B., Westendorp, R. G. J., & van Heemst, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.035 · Cited by 61 · see citing works
Effects of Cigarette Smoke Extracts on the Growth and Senescence of Skin Fibroblasts In Vitro
Yang, G., Zhang, C., Liu, X.-C., Ge, Q., & Deng, D. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.6162 · Cited by 56 · see citing works
Quantitative digital in situ senescence-associated β-galactosidase assay
Shlush, L. I., Itzkovitz, S., Cohen, A. A., Rutenberg, A., Berkovitz, R., Yehezkel, S., Shahar, H., Selig, S., & Skorecki, K. L. (2011) · BMC Cell Biology · doi:10.1186/1471-2121-12-16 · Cited by 49 · see citing works
Telomerase and mammalian ageing: a critical appraisal
Goyns, M. H., & Lavery, W. L. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00095-6 · Cited by 47 · see citing works
Senescence and immortalization of human cells
Duncan, E. L., Wadhwa, R., & Kaul, S. C. (2000) · Biogerontology · doi:10.1023/a:1010000132671 · Cited by 45 · see citing works
Kanaki, T., Makrantonaki, E., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9392-x · Cited by 46 · see citing works
Harnessing α- l -fucosidase for in vivo cellular senescence imaging
Koo, S., Won, M., Li, H., Kim, W. Y., Li, M., Yan, C., Sharma, A. K., Guo, Z., Zhu, W., Sessler, J. L., et al. (2021) · Chemical Science · doi:10.1039/d1sc02259h · Cited by 45 · see citing works
Senescence and quiescence induced compromised function in cultured macrophages
Holt, D. J., & Grainger, D. W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.099 · Cited by 43 · see citing works
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
Morsli, S., Doherty, G. J., & Muñoz‐Espín, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111618 · Cited by 41 · see citing works
Induction of Apoptosis in Human Replicative Senescent Fibroblasts
DeJesus, V., Rios, I., Davis, C. P., Chen, Y., Calhoun, D. H., Zakeri, Z. F., & Hubbard, K. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5425 · Cited by 39 · see citing works
Coates, P. J. (2002) · The Journal of Pathology · doi:10.1002/path.1073 · Cited by 39 · see citing works
Huang, T., & Rivera‐Pérez, J. A. (2014) · genesis · doi:10.1002/dvg.22761 · Cited by 38 · see citing works
Termination of lifespan of SV40‐transformed human fibroblasts in crisis is due to apoptosis
Macera-Bloch, L. S., Houghton, J., Lenahan, M., Jha, K. K., & Ozer, H. L. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10062 · Cited by 37 · see citing works
Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice
Ng, P. Y., Zhang, C., Li, H., & Baker, D. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230109 · Cited by 38 · see citing works
Yu, B., Xu, P., Zhao, Z., Cai, J., Sternberg, P., & Chen, Y. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14758 · Cited by 33 · see citing works
Senescence‐associated β‐galactosidase activity in the developing avian retina
de Mera‐Rodríguez, J. A., Álvarez‐Hernán, G., Gañán, Y., Martín‐Partido, G., Rodríguez‐León, J., & Francisco‐Morcillo, J. (2019) · Developmental Dynamics · doi:10.1002/dvdy.74 · Cited by 31 · see citing works
Multiparameter flow cytometric detection and quantification of senescent cells in vitro
Adewoye, A. B., Tampakis, D., Follenzi, A., & Stolzing, A. (2020) · Biogerontology · doi:10.1007/s10522-020-09893-9 · Cited by 31 · see citing works
Senescence-like phenotype in post-mitotic cells of mice entering middle age
Raffaele, M., Kovacovicova, K., Bonomini, F., Rezzani, R., Frohlich, J., & Vinciguerra, M. (2020) · Aging · doi:10.18632/aging.103637 · Cited by 28 · see citing works
Escriche‐Navarro, B., Garrido, E. M. N., Sancenón, F., García‐Fernández, A., & Martínez‐Máñez, R. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.002 · Cited by 27 · see citing works
Vitamin E Supplementation Delays Cellular SenescenceIn Vitro
Fata, G. L., Seifert, N., Weber, P., & Mohajeri, M. H. (2015) · BioMed Research International · doi:10.1155/2015/563247 · Cited by 24 · see citing works
Werner, E., Wang, H., & Doetsch, P. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108234 · Cited by 24 · see citing works
Yang, Y., Melzer, C., Bucan, V., von der Ohe, J., Otte, A., & Hass, R. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0289-0 · Cited by 24 · see citing works
Self-citationKhokhlov, A. N. (2013) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392513040123 · Cited by 18 · see citing works
Wlaschek, M., Hommel, C., Wenk, J., Brenneisen, P., Ma, W., Herrmann, G., & Scharffetter‐Kochanek, K. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00120.x · Cited by 16 · see citing works
Krasnov, G. S., Пузанов, Г. А., Afanasyeva, M. A., Dashinimaev, E. B., Vishnyakova, K. S., Beniaminov, A. D., Adzhubei, A. A., Kondratieva, T. T., Yegorov, Y. E., & Senchenko, V. N. (2019) · Bioscience Reports · doi:10.1042/bsr20193094 · Cited by 15 · see citing works
Self-citationMolecular Mechanisms of Cellular Senescence
Becker, T. M., & Haferkamp, S. (2013) · InTech eBooks · doi:10.5772/54120 · Cited by 14 · see citing works
Gerosuppression in confluent cells
Leontieva, O. V., & Blagosklonny, M. V. (2014) · Aging · doi:10.18632/aging.100714 · Cited by 14 · see citing works
Васильевна, М. Г., Колесников, А. В., Клебанов, А. А., & Khokhlov, A. N. (2015) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392515040082 · Cited by 14 · see citing works
Jamhiri, I., Hosseini, S. Y., Mehrabani, D., Khodabandeh, Z., Yaghobi, R., Dowran, R., & Zahri, S. (2017) · Biomedical Reports · doi:10.3892/br.2017.931 · Cited by 12 · see citing works
Senescent Accelerated Mouse (SAM): A Model that Binds In Vivo and In Vitro Aging
Yegorov, Y. E., Semenova, I. V., Karachentsev, D., Semenova, М. L., Akimov, S. S., Yegorova, I. N., & Zelenin, A. V. (2001) · Rejuvenation Research · doi:10.1089/109454501750225677 · Cited by 12 · see citing works
Self-citationMaria Jose Perez, J., Lam, A., Weissleder, C., Bertoli, F., Raji, H., Bosch, M., Nemazanyy, I., Kalb, S., Kehili, M., Hirschberg, I., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02320-1 · Cited by 14 · see citing works
Detecting cellular senescence in vivo: Imagining imaging better
Rabinowitz, Z. M., & Cui, L. (2023) · Aging and Cancer · doi:10.1002/aac2.12067 · Cited by 10 · see citing works
Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach
Althubiti, M., & Macip, S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_14 · Cited by 10 · see citing works
Khokhlov, A. N. (2014) · Advances in Gerontology · doi:10.1134/s2079057014020088 · Cited by 10 · see citing works
Network of extracellular vesicles surrounding senescent cells
Okawa, H., Tanaka, Y., & Takahashi, A. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109953 · Cited by 8 · see citing works
Bianchi, A., Lipchick, B. C., & Nikiforov, M. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_1 · Cited by 8 · see citing works
Sangsuwan, T., Khavari, A. P., Blomberg, E., Romell, T., Godoy, P. R. D. V., Harms‐Ringdahl, M., & Haghdoost, S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2811296 · Cited by 7 · see citing works
Escriche‐Navarro, B., Garrido, E., Escudero, A. C., Montoya-Méndez, I., Sancenón, F., García‐Fernández, A., & Martínez‐Máñez, R. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123461 · Cited by 6 · see citing works
Research Article: Beta-galactosidase staining as a marker of cells enduring stress
Wood, M., & Cavender, J. F. (2004) · BIOS · doi:10.1893/0005-3155(2004)075 · Cited by 5 · see citing works
The role of telomerase in age-related degenerative disease and cancer
Fossel, M. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)07019-5 · Cited by 5 · see citing works
Mosaic Regulation of Stress Pathways Underlies Senescent Cell HeterogeneityPreprint
Avelar, R. A., Duffield, T., Lagger, C., Krstevska, N., Breuer, M., & de Magalhães, J. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.03.616489 · Cited by 5 · see citing works
Otsuka, T., & Matsui, H. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112087 · Cited by 6 · see citing works
The application of aptamers in the field of aging and age‐related diseases
Xu, L., Jiang, B., Qiu, W., Jiang, C., Zhang, F., & Tan, W. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.346 · Cited by 4 · see citing works
Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life?
Yegorov, Y. E. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923110032 · Cited by 3 · see citing works
Self-citationThe Multifaceted Phenotype of Senescent HL-60/S4 MacrophagesPreprint
Olins, A. L., Welch, D. B. M., Saul, D., Prudovsky, I. A., & Olins, D. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.15.598082 · Cited by 3 · see citing works
Self-citationHartono, M., Ge, J., Denholm, M., Ellis, M. G., Henríquez, J. A., Baker, A. G., Rintoul, R. C., Euser, T. G., Fruk, L., & Muñoz‐Espín, D. (2026) · Nature Aging · doi:10.1038/s43587-026-01116-z · Cited by 2 · see citing works
Cellular senescence and its pathogenic and therapeutic implications in autoimmune hepatitis
Czaja, A. J. (2024) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2024.2432480 · Cited by 2 · see citing works
Prudovsky, I. A., Landriscina, M., Soldi, R., Bellum, S. C., Small, D. J., Andreeva, V., & Maciag, T. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)27290-x · Cited by 1 · see citing works
Self-citationYegorov, Y. E., Semenova, I. V., Andreeva, V., Akimov, S. S., Prudovsky, I. A., & Zelenin, A. V. (2002) · Molecular Biology · doi:10.1023/a:1016055212345
Self-citationModification of Human Fibroblast Properties in Microtransplant
Vishnyakova, K. S., Popov, K. V., Kudryavtseva, A. V., Садритдинова, А. Ф., Snezhkina, A. V., Tatosyan, K. A., Bardashev, V. A., & Egorov, E. E. (2014) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-014-2512-2
Comparison of Cellular Senescence Phenotype in Human Fibroblasts from New-born and Aged Donors.
Yi, H.-W., & Hwang, E.-S. (2008) · Journal of Life Science · doi:10.5352/jls.2008.18.3.344
Huang, T. (2014) · eScholarship@UMassChan · doi:10.13028/m26g63
The effect of radiation on cellular ageing
Sabin, R. J. (2012) · Brunel University Research Archive (BURA) (Brunel University London)
Vázquez-Villaseñor, I. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Olovnikov, telomeres and telomerase. is it possible to prolong a healthy life?
Yegorov, Y. E. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523110040
Self-citationGonzález-Meljem, J. M., Haston, S., Gallage, S., Innes, A. J., & Scheckhuber, C. Q. (2024) · Springer eBooks · doi:10.1007/978-3-031-76469-1_2
Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence
Nacka-Aleksić, M., Pirković, A., Vilotić, A., Kosanović, M., Dekanski, D., Legner, J., & Krivokuća, M. J. (2025) · Life · doi:10.3390/life15060918
Age-related alterations in the immune system of aging mice
С., М. К., & Shevyrev, D. (2025) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2025.043
Etrouth, S., Zhu, Y., & Zhang, D. (2026) · Journal of Respiration · doi:10.3390/jor6030021
- Authors
- Yegorov, Y. E., Akimov, S. S., Hass, R., Zelenin, A. V., & Prudovsky, I. A.
- Affiliations
- Engelhardt Institute of Molecular Biology (RU)
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Yegorov, Yegor E.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 243
- Issue
- 1
- Pages
- 207-211
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2063754902
- Cited by
- 90
- References
- 18
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- non-proliferating cells, cellular senescence, Swiss 3T3 cells, U937 cells, HL-60 cells, macrophage differentiation, phorbol ester, heparin, cytochemistry, pH 6.0
- MeSH terms
- Animals, beta-Galactosidase, Cell Differentiation, Cell Division, Cell Line, Fibroblasts, Hydrogen-Ion Concentration, 3T3 Cells, Cellular Senescence, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review