Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Open accessAbstract
Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
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The target specificity and toxicity to non-senescent cells is still a big hurdle for clinical applications of current senolytic treatments.
“The target specificity and toxicity to non-senescent cells is still a big hurdle for clinical applications of the current senolyitc treatments.14,15”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [14]
The Bcl-2-Targeting Senolytics section says hematological toxicities of Bcl-2 inhibitors raise safety issues that may impede clinical development, and it calls for more specific agents. The claim extends that concern to current senolytic treatments generally; the Other Senolytics section instead reports that dasatinib plus quercetin kills senescent cells but not the non-senescent counterparts tested. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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Unmasking Transcriptional Heterogeneity in Senescent Cells
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“Senescent cells manifest a robust, profound, and stable proinflammatory secretory activity with the expression spectrum largely conserved between different cell types, cell states, and stress types, although there are variations in the SASP signature, a form of heterogeneity driven by certain unknown mechanism(s) [20].”
BackgroundCellular senescence and its effector programs
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BackgroundMitochondria are required for pro-ageing features of the senescent phenotype
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Self-citationCardiac Glycosides as Senolytic Compounds
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Abdik, E. A., Kaleağasıoğlu, F., Abdik, H., Şahi̇n, F., & Berger, M. R. (2018) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000736 · Cited by 12 · cited 1× · see citing works
“ABT-737 is a Bcl-2 Homology 3 (BH3) domain mimetic that blocks the interaction between antiapoptotic molecules Bcl-2/Bcl-w/Bcl-XL and BH3 domain-containing proapoptotic proteins, thus inducing cell apoptosis [93,94].”
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603 · see citing works
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Self-citationAging of the cells: Insight into cellular senescence and detection Methods.
Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287 · see citing works
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases
Olivieri, F., Prattichizzo, F., Giuliani, A., Matacchione, G., Rippo, M. R., Sabbatinelli, J., & Bonafè, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101374 · Cited by 221 · see citing works
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Yin, Y., Chen, H., Wang, Y., Zhang, L., & Wang, X. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12154 · Cited by 196 · see citing works
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
Dou, X., Fu, Q., Long, Q., Liu, S., Zou, Y., Fu, D., Xu, Q., Jiang, Z., Ren, X., Zhang, G., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00912-w · Cited by 195 · see citing works
“Senescent cells exhibit phenotypic alterations, such as morphological flattening, nuclear expansion, epigenetic reorganization and metabolic alterations 3,4 .”
InfluentialSelf-citationTargeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly
Pereira, B. I., Xu, X., & Akbar, A. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583019 · Cited by 182 · see citing works
“Finally, it is likely that targeting other sources of inflammaging by changing the composition of the microbiome (176) or selectively removing senescent cells using senolytic drugs (177) may represent further opportunities for enhancing vaccine immunity in the setting of chronic inflammation.”
BackgroundCellular Senescence in Cardiovascular Diseases: A Systematic Review
Hu, C., Zhang, X., Teng, T., Ma, Z., & Tang, Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.0927 · Cited by 181 · see citing works
“Therapeutical approaches including pro-senescent and anti-senescent are well studied in several areas of aging pathology [139].”
BackgroundCellular senescence in musculoskeletal homeostasis, diseases, and regeneration
Wan, M., Gray-Gaillard, E. F., & Elisseeff, J. (2021) · Bone Research · doi:10.1038/s41413-021-00164-y · Cited by 143 · see citing works
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Sun, Y., Wang, X., Liu, T., Zhu, X., & Pan, X. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00815-5 · Cited by 151 · see citing works
Self-citationSingle-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
Tao, W., Yu, Z., & Han, J.-D. J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.009 · Cited by 147 · see citing works
Lee, J., & Lee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094843 · Cited by 147 · see citing works
“However, the accumulation of senescent cells with the progression of age contributes to the development of various aging-associated diseases [1,81].”
BackgroundLiu, H., Xu, Q., Wufuer, H., Li, Z., Sun, R., Jiang, Z., Dou, X., Fu, Q., Campisi, J., & Sun, Y. (2023) · Aging Cell · doi:10.1111/acel.13921 · Cited by 133 · see citing works
“…hallmark of organismal aging and promotes multiple chronic pathologies, including but not limited to neurodegenerative diseases, cardiovascular disor - ders, and various types of malignancies (Kirkland & Tchkonia, 2020; Song, Lam, et al., 2020 ; Song, Tchkonia, et al., 2020 ; Sun et al., 2022 ).”
BackgroundSelf-citationMediterranean diet and the hallmarks of ageing
Shannon, O. M., Ashor, A. W., Scialò, F., Saretzki, G. C., Martin-Ruiz, C. M., Lara, J., Matu, J., Griffiths, A., Robinson, N., Lionetti, L., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00841-x · Cited by 131 · see citing works
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science · doi:10.1002/advs.202002611 · Cited by 129 · see citing works
Self-citationBoyajian, J. L., Ghebretatios, M., Schaly, S., Islam, P., & Prakash, S. (2021) · Nutrients · doi:10.3390/nu13124550 · Cited by 143 · see citing works
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
Evangelou, K., Vasileiou, P. V. S., Papaspyropoulos, A., Hazapis, O. G., Petty, R., Demaria, M., & Gorgoulis, V. G. (2022) · Physiological Reviews · doi:10.1152/physrev.00007.2022 · Cited by 124 · see citing works
Cellular senescence: Neither irreversible nor reversible
Reimann, M., Lee, S., & Schmitt, C. A. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20232136 · Cited by 120 · see citing works
“…2019; Hayflick and Moorhead, 1961; Lee and Schmitt, 2019; Lee et al., 2021; McHugh and Gil, 2018; Muñoz-Esp´ ı n et al., 2013; Schmitt et al., 2023; Song et al., 2020; Storer et al., 2013; Yu et al., 1990) Reduced mitochondrial activity to protect from oxidative damage (Marescal and Cheeseman,…”
BackgroundA common signature of cellular senescence; does it exist?
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101458 · Cited by 120 · see citing works
Hou, Y., Chen, M., Bian, Y., Hu, Y., Chuan, J., Zhong, L., Zhu, Y., & Tong, R. (2024) · npj Vaccines · doi:10.1038/s41541-024-00874-4 · Cited by 116 · see citing works
“Additionally, as the main source of in fl ammatory factors, removing senescent cells can also be expected to become an approachto enhance the effectiveness of vaccines 118 .”
BackgroundEvidence and perspectives of cell senescence in neurodegenerative diseases
Si, Z., Sun, L., & Wang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111327 · Cited by 105 · see citing works
Iakovou, E., & Kourti, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827900 · Cited by 113 · see citing works
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 110 · see citing works
Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
Sun, Y., Li, Q., & Kirkland, J. L. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac030 · Cited by 105 · see citing works
Self-citationKrzystyniak, A., Wesierska, M., Petrazzo, G., Gadecka, A., Dudkowska, M., Bielak-Zmijewska, A., Mosieniak, G., Figiel, I., Wlodarczyk, J., & Sikora, E. (2022) · Aging · doi:10.18632/aging.203835 · Cited by 105 · see citing works
“Fisetin or D+Q appear to be the most effective senolytics tested in many preclinical studies and growing body of clinical trials [20, 24].”
BackgroundEpigenetic reprogramming as a key to reverse ageing and increase longevity
Pereira, B., Correia, F. P., Alves, I. A., Costa, M., Gameiro, M. D., Martins, A. P., & Saraiva, J. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102204 · Cited by 108 · see citing works
Liu, H., Zhao, H., & Sun, Y. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.004 · Cited by 96 · see citing works
Self-citationTripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging · doi:10.18632/aging.203560 · Cited by 88 · see citing works
Self-citationDissecting primary and secondary senescence to enable new senotherapeutic strategies
Admasu, T. D., Rae, M. J., & Stolzing, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101412 · Cited by 92 · see citing works
Preininger, M. K., & Kaufer, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116217 · Cited by 84 · see citing works
Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring
Hartmann, A., Hartmann, C., Secci, R., Hermann, A., Fuellen, G., & Walter, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.686320 · Cited by 81 · see citing works
“…age“) or PET-Scans (e.g., TAU-PET, detecting the continuous increase of TAU deposition in temporo-parietal-occipital lobes) should be considered (Sowell et al., 2003; Cole et al., 2015; Schöll et al., 2016). cells usually have an increased lysosomal content, which can be detected…”
BackgroundCellular senescence and kidney aging
Rex, N., Melk, A., & Schmitt, R. (2023) · Clinical Science · doi:10.1042/cs20230140 · Cited by 83 · see citing works
“…cells concerning their phenotypes and molecular profiles, the lack of standardized protocols leading to variability in results across different studies, the difficulty of detecting senescent cells in complex tissues due to a multitude of cell types and complex spatial distribution [66–68].”
BackgroundCellular senescence in the aging brain: A promising target for neurodegenerative diseases
Sahu, M. R., Rani, L., Subba, R., & Mondal, A. C. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111675 · Cited by 75 · see citing works
Giroud, J., Bouriez, I., Paulus, H., Pourtier, A., Debacq‐Chainiaux, F., & Pluquet, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310788 · Cited by 77 · see citing works
“Moreover, the accumulation of senescent cells is also detected at pathological sites due to various stress signals regardless of age [115].”
BackgroundOxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons
Stojanović, B., Jovanovic, I., Stojanovic, M. D., Stojanović, B., Kovačević, V., Radosavljević, I., Jovanović, D., Kovačević, M. M., Zornić, N., Arsić, A. A., et al. (2025) · Antioxidants · doi:10.3390/antiox14080987 · Cited by 81 · see citing works
“Consequently, the targeted elimination of these cells has emerged as a promising strategy to restore tissue homeostasis and delay age-related decline [195].”
Magnesium and the Hallmarks of Aging
Dominguez, L. J., Veronese, N., & Barbagallo, M. (2024) · Nutrients · doi:10.3390/nu16040496 · Cited by 75 · see citing works
“In experimental animals, healthspan has been extended by killing senescent cells with pharmacological and genetic treatments [167].”
BackgroundRole of E2F transcription factor in oral cancer: Recent insight and advancements
Kassab, A., Gupta, I., & Moustafa, A. A. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.004 · Cited by 68 · see citing works
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“cells have attracted increasing attention as a potent therapeutic target for age-related diseases, including cancer, a leading cause of morbidity and mortality in the elderly 5 .”
Self-citationRetractedDNA repair as a shared hallmark in cancer and ageing
Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 68 · see citing works
Morimoto, K., Yamada, T., Yokoi, T., Kijima, T., Gotô, Y., Nakao, A., Hibino, M., Takeda, T., Yamaguchi, H., Takumi, C., et al. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.08.015 · Cited by 59 · see citing works
Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration
Malecki, K. M. C., Andersen, J. K., Geller, A. M., Harry, G. J., Jackson, C. L., James, K. A., Miller, G. W., & Ottinger, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.824921 · Cited by 61 · see citing works
THERAPY-INDUCED POLYPLOIDIZATION AND SENESCENCE; COINCIDENCE OR INTERCONNECTION?
Sikora, E., Czarnecka-Herok, J., Bojko, A., & Sunderland, P. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.015 · Cited by 57 · see citing works
Mbara, K. C., Devnarain, N., & Owira, P. M. O. (2022) · Pharmaceutical Medicine · doi:10.1007/s40290-022-00444-w · Cited by 60 · see citing works
“6 billion, imposing a socioeconomic burden on a frail elderly population [1].”
BackgroundThe Footprint of Kynurenine Pathway in Cardiovascular Diseases
Ala, M., & Eftekhar, S. P. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469221096643 · Cited by 57 · see citing works
Matacchione, G., Gurău, F., Silvestrini, A., Tiboni, M., Mancini, L., Valli, D., Rippo, M. R., Recchioni, R., Marcheselli, F., Carnevali, O., et al. (2021) · Biogerontology · doi:10.1007/s10522-021-09915-0 · Cited by 54 · see citing works
“…LPS. Curcumin and Resveratrol (RSV) have been deeply described for their anti-inflammatory property both in monocytic and endothelial cells (Rana et al. 2016; Schwager et al. 2017; Sun et al. 2015), whereas BCP was only recently identified as an anti-inflammatory compound (Yamaguchi and Levy 2019).”
BackgroundAging and Options to Halt Declining Immunity to Virus Infections
Palacios-Pedrero, M. Á., Osterhaus, A. D. M. E., Becker, T., Elbahesh, H., Rimmelzwaan, G. F., & Saletti, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681449 · Cited by 55 · see citing works
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Merdji, H., Schini‐Kerth, V. B., Meziani, F., & Toti, F. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00937-y · Cited by 53 · see citing works
Elevated skin senescence in young mice causes delayed wound healing
Thanapaul, R. J. R. S., Shvedova, M., Shin, G. H., Crouch, J. D., & Roh, D. S. (2022) · GeroScience · doi:10.1007/s11357-022-00551-1 · Cited by 52 · see citing works
Senescent cells in cancer therapy: why and how to remove them
Zhang, J., Zhang, D., & Yu, B. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.07.002 · Cited by 50 · see citing works
Fisetin for COVID ‐19 in skilled nursing facilities: Senolytic trials in the COVID era
Verdoorn, B. P., Evans, T. K., Hanson, G. J., Zhu, Y. Z., Prata, L. G. P. L., Pignolo, R. J., Atkinson, E. J., Gerdes, E. O. W., Kuchel, G. A., Mannick, J. B., et al. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17416 · Cited by 50 · see citing works
“, bradykinins, ceramides, prostaglandins), tissue damaging, proinflammatory, noncoding nucleotides (including micro-RNAs, mitochondrial DNA), exosomes, and other factors that contribute to tissue necrosis, fibrosis, systemic inflammation, immune dysfunction, and spread of senescence (Figure 1).(14,15) The impact of Sn…”
Self-citationIdentification of GL-V9 as a novel senolytic agent against senescent breast cancer cells
Yang, D., Tian, X., Ye, Y., Liang, Y., Zhao, J., Wu, T., & Lu, N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119196 · Cited by 50 · see citing works
Li, Q., Zhao, Y., Xu, C., Liang, Y., Zhao, Y., He, Q., Li, J., Chen, K., Qiao, H., Liu, N., et al. (2023) · Advanced Science · doi:10.1002/advs.202205668 · Cited by 48 · see citing works
Rizzo, M. G., Best, T. M., Huard, J., Philippon, M. J., Hornicek, F. J., Duan, Z., Griswold, A. J., Kaplan, L. D., Hare, J. M., & Kouroupis, D. (2023) · Cells · doi:10.3390/cells12101421 · Cited by 46 · see citing works
González-Meljem, J. M., & Martı́nez-Barberá, J. P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03798-7 · Cited by 47 · see citing works
“Senolytic therapies have thoroughly been reviewed elsewhere [27, 171, 172] The previously discussed cell autonomous and nonautonomous functions of senescent cells in tumourigenesis have provided a strong rationale to explore the potential of”
BackgroundWang, L. Y., Xiong, B., Lü, W., Cheng, Y., Zhu, J., Ai, G., Zhang, X., Liu, X., & Cheng, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116474 · Cited by 45 · see citing works
The role of vitamin D on redox regulation and cellular senescence
Sosa-Díaz, E., Cruz, E. Y. H., & Pedraza‐Chaverrí, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.003 · Cited by 43 · see citing works
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration
Thapa, R., Bhat, A. A., Shahwan, M. J., Ali, H., Padmapriya, G., Bansal, P., Rajotiya, S., Barwal, A., Prasad, G. V. S., Pramanik, A., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149202 · Cited by 44 · see citing works
Bai, Z., Yang, P., Yu, F., Li, Z., Yao, Z., Martinez, J., Li, M., & Xu, H. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04562-w · Cited by 43 · see citing works
Aging and respiratory viral infection: from acute morbidity to chronic sequelae
Wu, Y., Goplen, N. P., & Sun, J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00624-2 · Cited by 40 · see citing works
“Cellular senescence describes a process characterized by permanent cell cycle arrest and gain of senescenceassociated secretory phenotype (SASP), a pro-inflammatory secretome [17].”
BackgroundSchroeder, H. T., Muller, C. H. D. L., Heck, T. G., Krause, M. D. S., & de Bittencourt, P. I. H. (2024) · Cell Stress and Chaperones · doi:10.1016/j.cstres.2024.01.002 · Cited by 42 · see citing works
Focus on senescence: Clinical significance and practical applications
Boccardi, V., Orr, M. E., Polidori, M. C., Ruggiero, C., & Mecocci, P. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13775 · Cited by 40 · see citing works
“It typically occurs in response to harmful stimuli such as telomere shortening (replicative senescence), DNA damage (DNA damage-induced senescence), and oncogenic signaling (oncogene-induced senescence) [29, 30].”
BackgroundSenescence-mediated anticancer effects of quercetin
Özsoy, S., Becer, E., & Vatansever, H. S. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.04.007 · Cited by 39 · see citing works
Zhang, H., Xu, Q., Jiang, Z., Sun, R., Wang, Q., Liu, S., Luan, X., Campisi, J., Kirkland, J. L., Zhang, W., et al. (2025) · Advanced Science · doi:10.1002/advs.202412950 · Cited by 38 · see citing works
Self-citationRamadhiani, R., Ikeda, K., Miyagawa, K., Ryanto, G. R. T., Tamada, N., Suzuki, Y., Kirita, Y., Matoba, S., Hirata, K., & Emoto, N. (2023) · iScience · doi:10.1016/j.isci.2023.106662 · Cited by 37 · see citing works
Ristori, S., Bertoni, G., Bientinesi, E., & Monti, D. (2025) · Nutrients · doi:10.3390/nu17111837 · Cited by 41 · see citing works
“Among the senolytics tested in multiple preclinical studies and increasing clinical trials, fisetin and D+Q appear to be the most effective [246,247].”
Heck, T. G., Ludwig, M. S., Frizzo, M. N., Rasia‐Filho, A. A., & de Bittencourt, P. I. H. (2020) · Clinical Science · doi:10.1042/cs20200596 · Cited by 35 · see citing works
Spinelli, R., Florese, P., Parrillo, L., Zatterale, F., Longo, M., D’Esposito, V., Desiderio, A., Nerstedt, A., Gustafson, B., Formisano, P., et al. (2022) · Aging Cell · doi:10.1111/acel.13557 · Cited by 36 · see citing works
Apparoo, Y., Phan, C., Kuppusamy, U. R., & Chan, E. W. C. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148693 · Cited by 35 · see citing works
Cao, Y., Ruan, J., Kang, J., Nie, X., Lan, W., Ruan, G., Li, J., Zhu, Z., Han, W., Tang, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202303614 · Cited by 36 · see citing works
Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy
Jiang, B., Zhang, W., Zhang, X., & Sun, Y. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.05.002 · Cited by 37 · see citing works
Self-citationWang, C., Long, Q., Fu, Q., Xu, Q., Fu, D., Li, Y., Gao, L., Guo, J., Zhang, X., Lam, E. W. ‐., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02476-7 · Cited by 34 · see citing works
“In cancer clinics, cellular senescence induced by chemotherapy and/or irradiation is referred to as therapy-induced senescence (TIS) [7].”
BackgroundSelf-citationOxidative Stress, Inflammation, and Cellular Senescence in Neuropathic Pain: Mechanistic Crosstalk
Stojanović, B., Bevc, I. M., Stojanovic, M. D., Stojanović, B., Lazarević, T., Spasić, M., Petrovic, M., Stefanovic, I., Marković, M., Nešić, J., et al. (2025) · Antioxidants · doi:10.3390/antiox14101166 · Cited by 33 · see citing works
“Biochemi-cally, they accumulate lipofuscin and show enhanced activity of lysosomal β -galactosidase, commonly detected as SA-β -gal [177,178].”
Shen, K., Zhou, H., Zuo, Q., Gu, Y., Cheng, J., Yan, K., Zhang, H., Song, H., Liang, W.-W., Zhou, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55335-2 · Cited by 32 · see citing works
“…fi nd that senescent cells maintain high metabolic activityandhaveanincreaseddemandforenergy,relyingonenhanced glycolysis to sustain their survival 49,50 , we cannot exclude the possibility that FLS senescence, resulting from TCA cycle blockade caused by GATD3A de fi ciency, further enhanced the…”
Erlangga, Z., Ghashang, S. K., Hamdan, I., Melk, A., Gutenbrunner, C. M., & Nugraha, B. (2023) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2023.200189 · Cited by 36 · see citing works
Kou, Y., Rong, X., Tang, R., Zhang, Y., Yang, P., Liu, H., Ma, W., & Li, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1067085 · Cited by 31 · see citing works
“Cell senescence is an important driving factor for aging andmany diseases (Rossman et al., 2017; Sun et al., 2018; Song et al., 2020).”
BackgroundAcid ceramidase promotes senescent cell survival
Munk, R. B., Anerillas, C., Rossi, M. S., Tsitsipatis, D., Martindale, J. L., Herman, A. B., Yang, J., Roberts, J. A., Varma, V. R., Pandey, P. R., et al. (2021) · Aging · doi:10.18632/aging.203170 · Cited by 30 · see citing works
“The accumulation of senescent cells in tissues and organs has been linked to the pathogenesis and severity of age-associated diseases such as cancer, arthritis, cataracts, neurodegeneration, and atherosclerosis [47].”
BackgroundAn old problem with new solutions: Strategies to improve vaccine efficacy in the elderly
Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29 · see citing works
Nanoparticles-based anti-aging treatment of Alzheimer’s disease
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- Authors
- Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y.
- Affiliations
- Binzhou Medical University (CN)
- Imperial College London (GB)
- Mayo Clinic (US)
- Corresponding author
- Sun, Yu
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 45
- Issue
- 7
- Pages
- 578-592
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC7649645
- OpenAlex
- W3014969606
- Cited by
- 195
- References
- 137
- Citations by year
- 2026: 23 · 2025: 27 · 2024: 30 · 2023: 30 · 2022: 40 · 2021: 39 · 2020: 6
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (P01 AG062413, R37-AG013925)
- Cancer Research UK (A12011)
- National Key Research and Development Program of China Stem Cell and Translational Research (2016YFC1302400)
- Breast Cancer Now (2012MayPR070, 2012NovPhD016)
- National Institute for Health Research
- Mayo Clinic
- National Key Research and Development Program of China
- Noaber Foundation
- U.S. Department of Defense (PC111703)
- National Natural Science Foundation of China (31871380, 81472709, 31671425)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, age-related diseases, senolytics, senolytic therapy, healthspan extension, chronic disease, geriatrics, neurodegeneration, cardiovascular disease, cancer
- MeSH terms
- Humans, Neoplasms, Phenotype, Cellular Senescence, Neurodegenerative Diseases
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