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EHD1—An EH-Domain-Containing Protein with a Specific Expression Pattern

Mintz, Liat, Galperin, Emilia, Pasmanik-Chor, Metsada, Tulzinsky, Sandra, Bromberg, Yael, Kozak, Christine A., Joyner, Alexandra, Fein, Amos, Horowitz, Mia·1999·Genomics
DOI 10.1006/geno.1999.5800
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Abstract

A cDNA that is a member of the eps15 homology (EH)-domain-containing family and is expressed differentially in testis was isolated from mouse and human. The corresponding genes map to the centromeric region of mouse chromosome 19 and to the region of conserved synteny on human chromosome 11q13. Northern analysis revealed two RNA species in mouse. In addition to the high levels in testis, expression was noted in kidney, heart, intestine, and brain. In human, three RNA species were evident. The smaller one was predominant in testis, while the largest species was evident in other tissues as well. The predicted protein sequence has an EH domain at its C-terminus, including an EF, a Ca2+ binding motif, and a central coiled-coil structure, as well as a nucleotide binding consensus site at its N-terminus. As such, it is a member of the EH-domain-containing protein family and was designated EHD1 (EH domain-containing 1). In cells in tissue culture, we localized EHD1 as a green fluorescent protein fusion protein, in transferrin-containing, endocytic vesicles. Immunostaining of different adult mouse organs revealed major expression of EHD1 in germ cells in meiosis, in the testes, in adipocytes, and in specific retinal layers. Results of in situ hybridization to whole embryos and immunohistochemical analyses indicated that EHD1 expression was already noted at day 9.5 in the limb buds and pharyngeal arches and at day 10.5 in sclerotomes, at various elements of the branchial apparatus (ma…

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  • Re-introduction of wild-type EHD1, but not dysfunctional EHD1 mutants, restores free cholesterol levels in Ehd1-/- MEFs.

    “returned to normal level upon re-introduction of wild-type, but not dysfunctional EHD1”

    From EHD1 regulates cholesterol homeostasis and lipid droplet storage (2007) · cites this paper as [18]

  • EHD1 plays a critical role in recycling of plasma membrane receptors (e.g., transferrin) internalized through clathrin-coated pits or independently of clathrin.

    “EHD1 [14] has been found to play a critical role in the recycling of plasma membrane receptors (ie., transferrin) that are internalized either through clathrin-coated pits [15-17], or independently of clathrin (MHC-I or β1 integrins) [18,19].”

    From EHD1 regulates cholesterol homeostasis and lipid droplet storage (2007) · cites this paper as [18]

  • The EHD1 mutants Myc-EHD1 ΔEH and Myc-EHD1 G65R are dysfunctional.

    “two previously described dysfunctional EHD1 mutants, Myc-EHD1 ΔEH and Myc-EHD1 G65R (Fig. 2D-G; stars)[15,18]”

    From EHD1 regulates cholesterol homeostasis and lipid droplet storage (2007) · cites this paper as [18]

Citations

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Metadata

Authors
Mintz, L., Galperin, E., Pasmanik-Chor, M., Tulzinsky, S., Bromberg, Y., Kozak, C. A., Joyner, A., Fein, A., & Horowitz, M.
Venue
Genomics
Publisher
Elsevier BV
Published
1999-07
Volume
59
Issue
1
Pages
66-76
ISSN
0888-7543
DOI
10.1006/geno.1999.5800
Cited by
80
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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