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Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing
Abstract
Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced isoforms that may function in synapse organization. We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from separate promoters. The neurexin genes are very large (up to 1.62 Mb), with the neurexin-3 gene occupying almost 2% of human chromosome 14. Although invertebrate and vertebrate neurexins exhibit a high degree of evolutionary conservation, only vertebrate neurexins are subject to extensive alternative splicing that uses mechanisms ranging from strings of mini-exons to multiple alternative splice donor and acceptor sites. Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing.
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“Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms88,89”
From The neurogenetics of alternative splicing (2016) · cites this paper as [89]
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Metadata
- Authors
- Tabuchi, K., & Südhof, T. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 79
- Issue
- 6
- Pages
- 849-859
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2051468191
- Cited by
- 305
- References
- 31
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 17
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH52804, R01MH052804)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- neurexin, alternative splicing, gene evolution, NRXN3, multiple promoters, mini-exon, alternative splice sites, Drosophila melanogaster, Caenorhabditis elegans, chromosome 14, gene structure
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Alternative Splicing, Sequence Analysis, DNA, Evolution, Molecular, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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