The effects of diethylstilbestrol (DES) before birth on the development of masculine behavior in juvenile female rhesus monkeys.
Abstract
Eight pregnant rhesus monkeys were injected with 100 microg diethylstilbestrol dipropionate (DESDP) from the 40th day of gestation until term, a long-term treatment. Male (n = 3) and female (n = 5) offspring were obtained. Five other pregnant females were injected with DESDP beginning on the 115th day of gestation and continuing until either the 140th day or term--a relatively short-term treatment. Five female infants were obtained from these short-term treatments. Monkeys from the treated pregnancies were assigned randomly to mother-infant social groups containing untreated male and female infants the same age. They were observed in their peer groups each weekday from 3 to 12 months of age, and the display of mounting and play behavior was recorded for each subject. Results showed that DESDP significantly increased the frequency of display of these juvenile behaviors only in long-term-treated females. However, one of the aspects of mounting that is characteristic of males (the ratio of complete to abortive mounts) was unaffected even by the long-term treatment. Thus, DESDP-treated females displayed a limited behavioral masculinization. Whether this limitation was due to dosage and/or timing or to a selective action of DESDP was not determined. DESDP-treated males were not altered in any measurable way compared to untreated males.
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Perinatal exposure to bisphenol A or diethylstilbestrol dipropionate increases play in female rats and rhesus macaques, respectively.
“Perinatal exposure to bisphenol A, an environmental estrogen, or diethylstilbestrol dipropionate, a synthetic estrogen, also increases play in female rats and rhesus macaques, respectively (Dessi-Fulgheri et al., 2002; Goy & Deputte, 1996).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Goy & Deputte, 1996
Juvenile social play behavior is influenced by neonatal estradiol and testosterone exposure.
“This difference is known to be influenced by neonatal estradiol and testosterone exposure, because manipulating these hormone levels can sex reverse differences in juvenile social play behavior in rats (6 -8) and nonhuman primates (9,10).”
From The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior (2010) · cites this paper as [9]
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- Authors
- Goy, R. W., & Deputte, B. L.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 30
- Issue
- 4
- Pages
- 379-386
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2168732152
- Cited by
- 43
- References
- 19
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2013: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- National Center for Research Resources (RR 00167, P51RR000167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- diethylstilbestrol, prenatal hormone exposure, masculinization, female rhesus monkeys, youth behavior, mounting behavior, play behavior, sex differences in behavior, pregnancy timing, dosage effect
- MeSH terms
- Animals, Diethylstilbestrol, Female, Macaca mulatta, Male, Pregnancy, Psychosexual Development, Sexual Behavior, Animal
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