Genetically Triggered Sexual Differentiation of Brain and Behavior
Abstract
The dominant theory of sexual differentiation of the brain holds that sex differences in brain anatomy and function arise because of the action of gonadal steroids during embryonic and neonatal life. In mammals, testicular steroids trigger masculine patterns of neural development, and feminine patterns of neural development occur in the absence of such testicular secretions. In contrast, gonadal differentiation in mammals is not initiated by hormonal mechanisms, but is regulated by the action of gene products such as SRY, a testis-determining gene on the Y chromosome. This paper argues that such genetic, nonhormonal signals may also trigger specific examples of sexual differentiation of the brain. This thesis is supported by two arguments. The first is that "direct genetic" (i.e., nonhormonal) control of sexual differentiation may be as likely to evolve as hormonal control. The second line of argument is that neural and nonneural dimorphisms have already been described that are not well explained by classical theories of steroid-dependent sexual differentiation and for which other factors need to be invoked.
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The origin of sexual differences in the brain begins before gonadal hormones are detected in plasma.
“The origin of sexual differences in the brain starts even before gonadal hormones are detected in the plasma (Arnold, 1996; Wade & Arnold, 1996).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Arnold, 1996
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“The origin of sexual differences in the brain starts even before gonadal hormones are detected in the plasma (Arnold, 1996; Wade & Arnold, 1996).”
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- Authors
- Arnold, A. P.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Arnold, Arthur P.
- ORCID
- Arnold, Arthur P.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 30
- Issue
- 4
- Pages
- 495-505
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2148260419
- Cited by
- 141
- References
- 0
- Citations by year
- 2023: 3 · 2022: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd032050-03)
- National Institute on Deafness and Other Communication Disorders (DC-00217, R01DC000217)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32050)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- sexual differentiation of the brain, sex differences in brain, sex steroids, SRY gene, testis-determining gene, brain-behavior relationship
- MeSH terms
- Animals, Behavior, Animal, Brain, Sex Characteristics
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