Local cold exposure test with a new arterial photoplethysmographic sensor in healthy controls and patients with secondary Raynaud’s phenomenon
Abstract
Local cold exposure tests are used to diagnose cold-induced vasospastic disorders and to evaluate therapeutic success. We investigated the pulsatile signal detected with a newly developed arterial photoplethysmography (APPG) method and the signal change induced by local cold exposure using a temperature-controlled finger holder, comparing it with laser Doppler flux (red and green laser, rLDF and gLDF) and red blood cell velocity measured in nailfold capillaries (CBV). Ten healthy volunteers and 10 age- and sex-matched patients suffering from Raynaud's phenomenon due to systemic sclerosis were investigated using a moderate cooling temperature of 16 degrees C for 5 min. All signals were recorded simultaneously. The results show a significant reduction of CBV (P < 0.0001), rLDF (P < 0.0003), and gLDF (P = 0.0214) during cooling and characteristic changes in the APPG signal (for instance a decrease in pulse wave amplitude; P < 0.0001). Significant differences in the APPG amplitude could be detected under resting conditions; at cooling temperatures there were also significant differences in CBV and APPG. The temperature-controlled finger holder with its built-in APPG probe appears to be a useful tool for evaluating the effect of local cooling on finger skin perfusion and differentiating between healthy controls and patients with secondary Raynaud's phenomenon due to systemic sclerosis. The gLDF signal was rather weak, limiting its value in cold stress tests. The differences between controls and patients in CBV were somewhat smaller than in previous studies, suggesting the advantage of lower local cooling temperatures, e.g., 12 degrees C.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are significant reductions in PPG pulse wave amplitudes (p < 0.0001) between healthy volunteers and individuals with systemic sclerosis both at rest and after cooling the finger to 16 degrees Celsius.
“They report significant reductions in PPG pulse wave amplitudes (p < 0.0001) between the groups both at rest and after cooling the finger to 16 degrees Celsius [156].”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [156]
Cites
Evaluation of a Laser Doppler Flowmeter for Measurement of Tissue Blood Flow
Nilsson, G., Tenland, T., & Öberg, P. Å. (1980) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1980.326582 · Cited by 1,105 · see citing works
An Introduction to Cardiovascular Physiology
(1991) · Elsevier eBooks · doi:10.1016/c2013-0-06523-1 · Cited by 558 · see citing works
THE BLOOD SUPPLY OF VARIOUS SKIN AREAS AS ESTIMATED BY THE PHOTOELECTRIC PLETHYSMOGRAPH
Hertzman, A. B. (1938) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1938.124.2.328 · Cited by 455 · see citing works
Öberg, P. Å. (2013) · Springer eBooks · doi:10.1007/978-3-642-28753-4_201135 · Cited by 326 · see citing works
Frerichs, K. U., & Feuerstein, G. (1990) · Molecular and Chemical Neuropathology · doi:10.1007/bf03160057 · Cited by 176 · see citing works
Tooke, J. E., Östergren, J., & Fagrell, B. (1983) · PubMed · Cited by 133 · see citing works
Krogstad, A., Elam, M., Karlsson, T., & Wallin, B. G. (1995) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)00178-m · Cited by 63 · see citing works
Cooke, E. D., & Nicolaides, A. N. (1990) · BMJ · doi:10.1136/bmj.300.6724.553 · Cited by 51 · see citing works
Infra-red Transmission of the Flesh
Cartwright, C. H. (1930) · Journal of the Optical Society of America · doi:10.1364/josa.20.000081 · Cited by 43 · see citing works
Photoplethysmography of the Distal Pulp in the Assessment of the Vasospastic Hand
Cooke, E. D., Bowcock, S. A., & Smith, A. T. (1985) · Angiology · doi:10.1177/000331978503600106 · Cited by 29 · see citing works
Lichtelektrische Plethysmogramme
Matthes, K. J., & Hauss, W. H. (1938) · Journal of Molecular Medicine · doi:10.1007/bf01778576 · Cited by 29 · see citing works
Lütolf, O., Chen, D., Zehnder, T., & Mahler, F. (1993) · Microvascular Research · doi:10.1006/mvre.1993.1060 · Cited by 28 · see citing works
Hales, J. R. S., Roberts, R. G. D., Westerman, R. A., Stephens, F. R. N., & Fawcett, A. A. (1993) · PubMed · Cited by 26 · see citing works
Hahn, M., Klyscz, T., Jünger, M., & Rassner, G. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02742.x · Cited by 21 · see citing works
Self-citationHahn, M., & Shore, A. C. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020234 · Cited by 21 · see citing works
Self-citationAdvantages and Limitations of One-Point Laser Doppler Perfusion Monitoring in Clinical Practice
Fagrell, B., & Nilsson, G. (1995) · Vascular Medicine Review · doi:10.1177/1358863x9500600202 · Cited by 17 · see citing works
A SIMPLE METHOD OF DEMONSTRATING CHANGES IN BLOOD SUPPLY OF THE EAR AND EFFECTS OF SOME MEASURES
HANZLIK, P. J., DeEds, F., & TERADA, B. (1936) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)04690-7 · Cited by 17 · see citing works
Associated diseases in patients with Raynaud's syndrome
Edwards, J. M., & Porter, J. M. (1990) · Vascular Medicine Review · doi:10.1177/1358836x9000100105 · Cited by 15 · see citing works
Hahn, M., Hahn, C., Bräuer, K., & Jünger, M. (1998) · PubMed · Cited by 15 · see citing works
Self-citationTelevision microscopes for studying biological microscopic material
Danilov, V. A. (1984) · Biomedical Engineering · doi:10.1007/bf00555542 · Cited by 14 · see citing works
Mahler, F., Meier, B., Frey, R., Bollinger, A., & Anliker, M. (1977) · PubMed · Cited by 14 · see citing works
Mahler, F., Saner, H. E., Annaheim, M., & Linder, H. R. (2015) · Mikrozirkulation in Forschung und Klinik/Progress in applied microcirculation · doi:10.1159/000412829 · Cited by 12 · see citing works
Hahn, M., Klyscz, T., Bohnenberger, G., & Jünger, M. (2008) · International Journal of Microcirculation · doi:10.1159/000179146 · Cited by 10 · see citing works
Self-citationLentner, A., Berger, F., & Wienert, V. (1994) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmte.1994.39.7-8.170 · Cited by 5 · see citing works
Optoelektronische Systemkonzepte für nichtinvasive Kreislaufdiagnostik
Blazek, V. (1991) · RWTH Publications (RWTH Aachen) · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Photoplethysmography and its application in clinical physiological measurement
Allen, J. (2007) · Physiological Measurement · doi:10.1088/0967-3334/28/3/r01 · Cited by 3,967 · see citing works
On the Analysis of Fingertip Photoplethysmogram Signals
Elgendi, M. (2012) · Current Cardiology Reviews · doi:10.2174/157340312801215782 · Cited by 1,206 · see citing works
Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring
Fine, J., Branan, K. L., Rodriguez, A. J., Boonya-ananta, T., Ajmal, Ramella-Roman, J. C., McShane, M. J., & Coté, G. L. (2021) · Biosensors · doi:10.3390/bios11040126 · Cited by 348 · see citing works
The effect of contacting force on photoplethysmographic signals
Teng, X. F., & Zhang, Y. T. (2004) · Physiological Measurement · doi:10.1088/0967-3334/25/5/020 · Cited by 171 · see citing works
Vascular function in systemic sclerosis
Herrick, A. L. (2000) · Current Opinion in Rheumatology · doi:10.1097/00002281-200011000-00009 · Cited by 126 · see citing works
‘ Go with the flow ’: A review of methods and advancements in blood flow imaging
Daly, S. M., & Leahy, M. J. (2012) · Journal of Biophotonics · doi:10.1002/jbio.201200071 · Cited by 117 · see citing works
Scardulla, F., Cosoli, G., Spinsante, S., Poli, A., Iadarola, G., Pernice, R., Busacca, A., Pasta, S., Scalise, L., & D’Acquisto, L. (2023) · Measurement · doi:10.1016/j.measurement.2023.113150 · Cited by 120 · see citing works
Correlation of infrared thermography and skin perfusion in Raynaud patients and in healthy controls
Schlager, O., Gschwandtner, M. E., Herberg, K., Frohner, T., Schillinger, M., Koppensteiner, R., & Mlekusch, W. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.01.010 · Cited by 76 · see citing works
Aging and Survival of Cutaneous Microvasculature
Chang, E., Yang, J., Nagavarapu, U., & Herron, G. S. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01714.x · Cited by 65 · see citing works
Martinsen, Ø. G., Clausen, S., Nysaether, J. B., & Grimnes, S. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.893472 · Cited by 47 · see citing works
The effect of local mild cold exposure on pulse transit time
Zhang, X.-Y., & Zhang, Y.-T. (2006) · Physiological Measurement · doi:10.1088/0967-3334/27/7/008 · Cited by 40 · see citing works
Effects of Contact Pressure in Reflectance Photoplethysmography in an In Vitro Tissue-Vessel Phantom
May, J. M., Mejía‐Mejía, E., Nomoni, M., Budidha, K., Choi, C., & Kyriacou, P. A. (2021) · Sensors · doi:10.3390/s21248421 · Cited by 42 · see citing works
Finger Thermoregulatory Model Assessing Functional Impairment in Raynaud’s Phenomenon
Mariotti, A., Grossi, G., Amerio, P., Orlando, G., Mattei, P. A., Tulli, A., Romani, G. L., & Merla, A. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9788-9 · Cited by 22 · see citing works
External factors that affect the photoplethysmography waveforms
Pi, I., Pi, I., & Wu, W. (2021) · SN Applied Sciences · doi:10.1007/s42452-021-04906-9 · Cited by 21 · see citing works
Differential diagnosis of Raynaud’s phenomenon based on modeling of finger thermoregulation
Ismail, E., Orlando, G., Corradini, M. L., Amerio, P., Romani, G. L., & Merla, A. (2014) · Physiological Measurement · doi:10.1088/0967-3334/35/4/703 · Cited by 20 · see citing works
Changes in the Photoplethysmogram Waveform After Exercise
Poon, C. C. Y., Teng, X. F., Wong, Y. M., Zhang, C., & Zhang, Y. (2006) · IEEE/EMBS International Summer School on Medical Devices and Biosensors (ISSS-MDBS) · doi:10.1109/issmd.2004.1689576 · Cited by 19 · see citing works
Rosato, E., ROSSI, C., Borghese, F., Molinaro, I., Pisarri, S., & Salsano, F. (2010) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181eecfad · Cited by 18 · see citing works
Wong, M. Y. M., & Zhang, Y. (2006) · Transdisciplinary Conference on Distributed Diagnosis and Home Healthcare (D2H2) · doi:10.1109/ddhh.2006.1624791 · Cited by 13 · see citing works
Lee, J., Yang, S.-M., Park, J., Kim, H. C., Kim, E., Jang, Y., Kim, J., & Kim, H. (2018) · Pediatric Anesthesia · doi:10.1111/pan.13415 · Cited by 9 · see citing works
Photoplethysmography for the assessment of peripheral vascular disease
Allen, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823374-0.00005-0 · Cited by 9 · see citing works
Effects of Physical Exercise on the Photoplethysmogram Waveform
Chellappan, K., Zahedi, E., & Ali, M. A. M. (2007) · IEEE Student Conference on Research and Development (SCOReD) · doi:10.1109/scored.2007.4451399 · Cited by 9 · see citing works
Non-invasive Methods of Assessing Raynaud’s Phenomenon
Murray, A. K., & Pauling, J. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1526-2_13 · Cited by 7 · see citing works
Tatsuro, K., KOUICHI, T., Kutomi, K., Imai, E., & Furui, S. (2002) · Clinical Nuclear Medicine · doi:10.1097/00003072-200202000-00013 · Cited by 7 · see citing works
Modeling Thermal Infrared Imaging Data for Differential Diagnosis
Ismail, E., & Merla, A. (2017) · Series in bioengineering · doi:10.1007/978-981-10-3147-2_27 · Cited by 6 · see citing works
Foo, J. Y. A. (2007) · Physiological Measurement · doi:10.1088/0967-3334/28/9/n01 · Cited by 5 · see citing works
The Effect of Local Cold Exposure on Pulse Transit Time
Zhang, X., & Zhang, Y. (2005) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2005.1617239 · Cited by 4 · see citing works
Laboratory Assessment of Raynaud’s Phenomenon
Murray, A. K. (2024) · Springer eBooks · doi:10.1007/978-3-031-52581-0_15 · Cited by 3 · see citing works
- Advances in Blood Flow Imaging
Wang, R. K., & Tuchin, V. V. (2013) · CRC Press eBooks · doi:10.1201/b15256-13 · Cited by 3 · see citing works
Daly, S. M., Jonathan, E., & Leahy, M. J. (2011) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.889099 · Cited by 2 · see citing works
The thermal imaging system design in the diagnosis and follow-up of Raynaud's Phenomenon
Kaçmaz, S., & Erçelebi, E. (2018) · International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT) · doi:10.1109/ismsit.2018.8567041 · Cited by 1 · see citing works
McElligott-Daly, S. (2013) · University of Limerick Institutional Repository (University of Limerick) · doi:10.34961/10103
Mariotti, A., & Merla, A. (2012) · CRC Press eBooks · doi:10.1201/b12938-22
Kołłątaj, W. P., Durakiewicz, M., & Szewczyk, L. (2003) · Acta Angiologica
- Authors
- Hahn, M., Hahn, C., Jünger, M., Steins, A., Zuder, D., Klyscz, T., Büchtemann, A., Rassner, G., & Blazek, V.
- Affiliations
- University of Tübingen (DE)
- ORCID
- Jünger, Michael
- Venue
- Microvascular Research
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 57
- Issue
- 2
- Pages
- 187-198
- ISSN
- 0026-2862 (ISSN-L)
- OpenAlex
- W1967376544
- Cited by
- 33
- References
- 25
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 4 · 2018: 2 · 2017: 1 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microvascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- secondary Raynaud's phenomenon, systemic sclerosis, cold-induced vasospasm, laser Doppler flowmetry, pulse wave amplitude
- MeSH terms
- Adult, Aged, Arteries, Blood Flow Velocity, Cold Temperature, Evaluation Studies as Topic, Female, Fingers, Humans, Male, Middle Aged, Raynaud Disease, Scleroderma, Systemic, Skin, Case-Control Studies, Laser-Doppler Flowmetry, Photoplethysmography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
