Fullerene-based antioxidants and neurodegenerative disorders.
Abstract
Water-soluble derivatives of buckminsterfullerene (C(60)) derivatives are a unique class of compounds with potent antioxidant properties. Studies on one class of these compounds, the malonic acid C(60) derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H(2)O(2), and were effective inhibitors of lipid peroxidation, as well. Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP(+) and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C(3) carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants are potential neuroprotective agents for other neurodegenerative disorders, including Parkinson's disease.
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Neuroprotective compounds based on carbon-60 fullerene have been fabricated using a nanotechnological approach.
“Neuroprotective compounds based on carbon-60 fullerene – the molecules having a 3-D pattern of evenly spaced carbon atoms, have been fabricated by the application of nanotechnological approach (Dugan et al., 2001).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
Free radicals such as superoxide, hydroxyl, peroxynitrite, and peroxide cause deleterious cellular alterations including DNA fragmentation, peroxidation of cell membrane lipids, mitochondrial energy disturbances, and alteration in functionality of transporter proteins.
“Free radicals, such as superoxide, hydroxyl, peroxynitrite, and peroxide, cause deleterious alterations in cells including DNA fragmentation, peroxidation of cell membrane lipids, mitochondrial energy disturbances and alteration in functionality of transporter proteins”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
Free radicals are considered the main culprit having a key role in the pathology of neurodegenerative, ischemic, and traumatic CNS disorders.
“they are considered as the main culprit having the key role in pathology of neurodegenerative, ischemic, and traumatic CNS disorders (Mahadik and Mukherjee, 1996; Dugan et al., 2001).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
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- Authors
- Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., & O'Malley, K. L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dugan, L.L.
- ORCID
- Dugan, L.L.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 7
- Issue
- 3
- Pages
- 243-246
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2126036130
- Cited by
- 338
- References
- 9
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 16 · 2023: 20 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 14 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 22
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Fullerene Chemistry and Applications
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
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