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Neurofilament-Immunoreactive Neurons in Alzheimer's Disease and Dementia with Lewy Bodies

Shepherd, Claire E., McCann, Heather, Thiel, Emma, Halliday, Glenda M.·2002·Neurobiology of Disease
DOI 10.1006/nbdi.2001.0469
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Abstract

The cortical neurons thought to be selectively affected in dementia with Lewy bodies (DLB) are those containing nonphosphorylated 200-kDa neurofilament (NF) protein. As these neurons are largely spared in Alzheimer's disease (AD), DLB and AD may impact on different cortical neuronal populations. The present study quantifies the NF-containing neurons in frontal and temporal cortex of 8 AD, 8 DLB, and 8 control cases. Formalin-fixed paraffin-embedded tissue was immunohistochemically stained with antibodies against nonphosphorylated and phosphorylated NF. Immunoreactive neurons were quantified by areal fraction analysis and corrected for cortical volume. As expected, nonphosphorylated and phosphorylated NF accumulated in the pathological hallmarks of AD and DLB. However, rather than a decrease in NF-containing neurons, a doubling of this population was observed in DLB, compared with AD and controls. This increased number of cortical NF-containing neurons reveal novel widespread cortical changes, beyond those explained by Lewy body formation, that are specific for DLB.

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Research works printed but not linked: 40

  1. Brion, 1999, Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease, Am. J. Pathol., 154, 255, 10.1016/S0002-9440(10)65272-8 · DOI
  2. Broe, 2001, Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies, Acta Neuropathol., 101, 616, 10.1007/s004010000337 · DOI
  3. Cork, 1986, Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease, J. Neuropathol. Exp. Neurol., 45, 56, 10.1097/00005072-198601000-00005 · DOI
  4. Couillard-Deprez, 1998, Protective effect of neurofilament heavy gene over-expression in motor neuron disease induced by mutant superoxide dismutase, Proc. Natl. Acad. Sci. USA, 95, 9626, 10.1073/pnas.95.16.9626 · DOI
  5. Coulliard-Despres, 2000, Extra axonal neurofilaments do not exacerbate disease caused by mutant Cu,Zn superoxide dismutase, Neurobiol. Dis., 7, 462, 10.1006/nbdi.2000.0296 · DOI
  6. Cullen, 1997, Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer's disease, Neuroscience, 78, 641, 10.1016/S0306-4522(96)00569-6 · DOI
  7. Double, 1996, Topography of brain atrophy during normal aging and Alzheimer's disease, Neurobiol. Aging., 17, 513, 10.1016/0197-4580(96)00005-X · DOI
  8. Duong, 1994, Immunoreactivity patterns in neurofibrillary tangles of the inferior temporal cortex in Alzheimer's disease, Mol. Chem. Neuropathol., 22, 105, 10.1007/BF03160099 · DOI
  9. Galvin, 1999, Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha, beta and gamma synuclein, Proc. Natl. Acad. Sci. USA, 96, 13450, 10.1073/pnas.96.23.13450 · DOI
  10. Gomez-Isla, 1999, Clinicopathological correlates in temporal cortex in dementia with Lewy bodies, Neurology, 53, 10.1212/WNL.53.9.2003 · DOI
  11. Gomez-Tortosa, 2001, Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies, Acta. Neuropathol., 101, 36, 10.1007/s004010000270 · DOI
  12. Gundersen, 1988, Some new, simple and efficient stereological methods and their use in pathological research and diagnosis, APMIS, 96, 379, 10.1111/j.1699-0463.1988.tb05320.x · DOI · Paper page
  13. Harasty, 1999, Specific temporoparietal gyral atrophy reflects the pattern of language dissolution in Alzheimer's disease, Brain, 122, 675, 10.1093/brain/122.4.675 · DOI
  14. Harding, 1998, Simplified neuropathological diagnosis of dementia with Lewy bodies, Neuropathol. Appl. Neurobiol., 24, 195, 10.1046/j.1365-2990.1998.00115.x · DOI
  15. Ishihara, 2001, Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments, J. Neurosci., 21, 6026, 10.1523/JNEUROSCI.21-16-06026.2001 · DOI
  16. Ishihara, 1999, Age-dependent emergence and progression of a tauopathy in transgenic mice over-expressing the shortest human tau isoform, Neuron, 24, 751, 10.1016/S0896-6273(00)81127-7 · DOI · Paper page
  17. King, 2000, Neuronal response to physical injury and its relationship to the pathology of Alzheimer's disease, Clin. Exp. Pharmacol. Physiol., 27, 548, 10.1046/j.1440-1681.2000.03292.x · DOI
  18. Klosen, 1990, Perikaryal neurofilament phosphorylation in axotomised and 6-OH-dopamine-lesioned CNS neurons, Brain. Res., 526, 259, 10.1016/0006-8993(90)91230-E · DOI
  19. Kong, 2000, Over-expression of neurofilament subunit NF-L and NF-H extends survival of a mouse model for amylotrophic lateral sclerosis, Neurosci. Lett., 281, 72, 10.1016/S0304-3940(00)00808-9 · DOI
  20. Kril, 2001, Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation, Acta Neuropathol.
  21. Lewis, 2000, Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein, Nat. Genetics, 25, 402, 10.1038/78078 · DOI · Paper page
  22. Masliah, 2001, Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease, Neurology, 56, 127, 10.1212/WNL.56.1.127 · DOI · Paper page
  23. Masliah, 2000, Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders, Science, 287, 1265, 10.1126/science.287.5456.1265 · DOI
  24. Masliah, 1993, An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease, Am. J. Pathol., 142, 871
  25. McKeith, 1996, Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop, Neurology, 47, 1113, 10.1212/WNL.47.5.1113 · DOI · Paper page
  26. Mirra, 1991, The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardisation of the neuropathologic assessment of Alzheimer's disease, Neurology, 41, 479, 10.1212/WNL.41.4.479 · DOI · Paper page
  27. Morrison, 1987, A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease, Brain. Res., 416, 331, 10.1016/0006-8993(87)90914-0 · DOI
  28. Mutaetova-Ladinska, 1993, Biochemical and anatonical redistribution of tau protein in Alzheimer's disease, Am. J. Pathol., 143, 565
  29. Pollanen, 1993, Pathology and biology of the Lewy body, J. Neuropathol. Exp. Neurol., 52, 183, 10.1097/00005072-199305000-00001 · DOI
  30. Shepherd, 2001, Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease, Neurobiol. Dis., 8, 136, 10.1006/nbdi.2000.0361 · DOI
  31. Sjorgen, 2001, Both total and phosphorylated tau are increased in Alzheimer's disease, J. Neurol. Neurosurg. Psychiatry., 70, 624, 10.1136/jnnp.70.5.624 · DOI
  32. Smith, 1995, Fragmentation of the neuronal cytoskeleton in the Lewy body variant of Alzheimer's disease, Neuroreport, 6, 673, 10.1097/00001756-199503000-00022 · DOI
  33. Terry, 2000, Cell death or synaptic loss in Alzheimer's disease, J. Neuropathol. Exp. Neurol., 59, 1118, 10.1093/jnen/59.12.1118 · DOI
  34. Tetzlaff, 1996, Reductions in motoneuronal neurofilament synthesis by successive axotomies: A possible explanation for the conditioned lesioning effect on axon regeneration, Exp. Neurol., 139, 95, 10.1006/exnr.1996.0084 · DOI
  35. 1997, Neurobiol. Aging, 18, S1, 10.1016/S0197-4580(97)00057-2 · DOI · Paper page
  36. Trojanowski, 1998, Aggregation of neurofilament and alpha synuclein proteins in Lewy bodies, Arch. Neurol., 55, 10.1001/archneur.55.2.151 · DOI
  37. Tu, 1997, Selective degeneration of purkinje cells with Lewy body-like inclusions in aged NFHLacZ transgenic mice, J. Neurosci., 17, 1064, 10.1523/JNEUROSCI.17-03-01064.1997 · DOI
  38. van der Putten, 2000, Neuropathology in mice expressing human alpha-synuclein, J. Neurosci., 20, 6021, 10.1523/JNEUROSCI.20-16-06021.2000 · DOI
  39. Wakabayashi, 1995, Cortical Lewy body-containing neurons are pyramidal cells: Laser confocal imaging of double-immunolabeled sections with anti-ubiquitin and SMI32, Acta Neuropathol., 89, 404, 10.1007/BF00307643 · DOI
  40. Wong, 1990, Differential regulation of peripherin and neurofilament gene expression in regenerating rat DRG neurons, J. Neurosci. Res., 3, 332, 10.1002/jnr.490270312 · DOI

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Metadata

Authors
Shepherd, C. E., McCann, H., Thiel, E., & Halliday, G. M.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2002-03
Volume
9
Issue
2
Pages
249-257
ISSN
0969-9961
DOI
10.1006/nbdi.2001.0469
Cited by
34
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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