Cited by 249Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

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Sokolova, Anna, Hill, Michelle D., Rahimi, Farid, Warden, Lolita A., Halliday, Glenda M., Shepherd, Claire E.·2009·Brain Pathology

Abstract

Chronic neuroinflammation correlates with cognitive decline and brain atrophy in Alzheimer's disease (AD), and cytokines and chemokines mediate the inflammatory response. However, quantitation of cytokines and chemokines in AD brain tissue has only been carried out for a small number of mediators with variable results. We simultaneously quantified 17 cytokines and chemokines in brain tissue extracts from controls (n = 10) and from patients with and without genetic forms of AD (n = 12). Group comparisons accounting for multiple testing revealed that monocyte chemoattractant protein‐1 (MCP‐1), interleukin‐6 (IL‐6) and interleukin‐8 (IL‐8) were consistently upregulated in AD brain tissue. Immunohistochemistry for MCP‐1, IL‐6 and IL‐8 confirmed this increase and determined localization of these factors in neurons (MCP‐1, IL‐6, IL‐8), astrocytes (MCP‐1, IL‐6) and plaque pathology (MCP‐1, IL‐8). Logistic linear regression modeling determined that MCP‐1 was the most reliable predictor of disease. Our data support previous work on significant increases in IL‐6 and IL‐8 in AD but indicate that MCP‐1 may play a more dominant role in chronic inflammation in AD.

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Crossref · 10.1111/j.1750-3639.2008.00188.x

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Authors
Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A., Halliday, G. M., & Shepherd, C. E.
Affiliations
Neuroscience Research Australia (AU)
Venue
Brain Pathology
Publisher
Wiley
Published
2009-06-10
Volume
19
Issue
3
Pages
392-398
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
OpenAlex
W2091102323
Cited by
249
References
52
Citations by year
2026: 12 · 2025: 15 · 2024: 13 · 2023: 21 · 2022: 13 · 2021: 22 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 10 · 2016: 15 · 2015: 15 · 2014: 16 · 2013: 10 · 2012: 7
FWCI
9.40
Type
journal article
Language
en
Open access
Locations
  • Brain Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, MCP-1, neuroinflammation, cytokines, chemokines, interleukin-6, interleukin-8, amyloid plaques, astrocytes, neurons, biomarkers, brain tissue
MeSH terms
Adult, Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Brain, Female, Humans, Immunohistochemistry, Inflammation, Male, Middle Aged, Neurons, Interleukin-6, Interleukin-8, Chemokine CCL2, Plaque, Amyloid

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