Review: Disruption of the Postsynaptic Density in Alzheimer’s Disease and Other Neurodegenerative Dementias

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

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Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

PDZ domain proteins of synapses

Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,565 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 1× · see citing works

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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PSD-95 Involvement in Maturation of Excitatory Synapses

El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works

Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity

Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269 · see citing works

Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics

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Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061 · see citing works

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works

Dentritic spines : structure, dynamics and regulation

Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961 · see citing works

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-04.2004 · Cited by 954 · see citing works

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Koffie, R. M., Meyer-Luehmann, M., Hashimoto, T., Adams, K. W., Mielke, M. L., Garcia-Alloza, M., Micheva, K. D., Smith, S. J., Kim, M. L., Lee, V. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811698106 · Cited by 850 · see citing works

Signal-Processing Machines at the Postsynaptic Density

Kennedy, M. B. (2000) · Science · doi:10.1126/science.290.5492.750 · Cited by 788 · see citing works

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

Lu, K. P., & Zhou, X. Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2261 · Cited by 682 · see citing works

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works

A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease

Coon, K. D., Myers, A. J., Craig, D. W., Webster, J. A., Pearson, J. V., Lince, D. H., Zismann, V. L., Beach, T. G., Leung, D., Bryden, L., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0419 · Cited by 569 · see citing works

Spine growth precedes synapse formation in the adult neocortex in vivo

Knott, G. W., Holtmaat, A., Wilbrecht, L., Welker, E., & Svoboda, K. (2006) · Nature Neuroscience · doi:10.1038/nn1747 · Cited by 563 · see citing works

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

Wang, J., Grundke, I., & Iqbal, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05226.x · Cited by 553 · see citing works

PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

Christopherson, K. S., Hillier, B. J., Lim, W. A., & Bredt, D. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27467 · Cited by 542 · see citing works

Reelin, lipoprotein receptors and synaptic plasticity

Herz, J., & Chen, Y. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2009 · Cited by 524 · see citing works

Cadherin Regulates Dendritic Spine Morphogenesis

Togashi, H., Abe, K., Mizoguchi, A., Takaoka, K., Chisaka, O., & Takeichi, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00748-1 · Cited by 485 · see citing works

PSD-95 is required for activity-driven synapse stabilization.

Ehrlich, I., Klein, M., Rumpel, S., & Malinow, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609307104 · Cited by 470 · see citing works

A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

Marambaud, P., Wen, P. H., Dutt, A., Shioi, J., Takashima, A., Siman, R., & Robakis, N. K. R. K. (2003) · Cell · doi:10.1016/j.cell.2003.08.008 · Cited by 465 · see citing works

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000955200 · Cited by 450 · see citing works

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., & Gouras, G. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5167-03.2004 · Cited by 445 · see citing works

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., & Gong, C.-X. (2009) · Brain · doi:10.1093/brain/awp099 · Cited by 439 · see citing works

A Model for Central Synaptic Junctional Complex Formation Based on the Differential Adhesive Specificities of the Cadherins

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Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

Wu, H.-Y., Hudry, E., Hashimoto, T., Kuchibhotla, K., Rozkalne, A., Fan, Z., Spires-Jones, T., Xie, H., Arbel-Ornath, M., Grosskreutz, C. L., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-09.2010 · Cited by 367 · see citing works

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

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Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360 · see citing works

Spine architecture and synaptic plasticity

Carlisle, H. J., & Kennedy, M. B. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.008 · Cited by 351 · see citing works

Synaptic slaughter in Alzheimer's disease

Coleman, P. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.001 · Cited by 351 · see citing works

N-Cadherin Redistribution during Synaptogenesis in Hippocampal Neurons

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Molecular organization of the postsynaptic specialization

Sheng, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111146298 · Cited by 336 · see citing works

The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses

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Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons

Ji, Y., Pang, P. T., Feng, L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1381 · Cited by 326 · see citing works

Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Futai, K., Kim, M. J., Hashikawa, T., Scheiffele, P., Sheng, M., & Hayashi, Y. (2007) · Nature Neuroscience · doi:10.1038/nn1837 · Cited by 304 · see citing works

Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons

Roussignol, G., Ango, F., Romorini, S., Tu, J. C., Sala, C., Worley, P. F., Bockaert, J., & Fagni, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4354-04.2005 · Cited by 293 · see citing works

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292 · see citing works

Soluble β-Amyloid1-40Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses

Roselli, F., Tirard, M., Lu, J., Hutzler, P., Lamberti, P., Livrea, P., Morabito, M. A., & Almeida, O. F. X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-05.2005 · Cited by 276 · see citing works

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

Simmons, D. A., Rex, C. S., Palmer, L. C., Pandyarajan, V., Fedulov, V., Gall, C. M., & LYNCH, G. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811228106 · Cited by 261 · see citing works

Modulation of D2R-NR2B Interactions in Response to Cocaine

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Synaptic Changes in Alzheimer's Disease

Gylys, K. H., Fein, J. A., Yang, F., Wiley, D. J., Miller, C. A., & Cole, G. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63436-0 · Cited by 253 · see citing works

The postsynaptic density

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Structural Principles of Tau and the Paired Helical Filaments of Alzheimer's Disease

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Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus

Hajszán, T., MacLusky, N. J., & Leranth, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03968.x · Cited by 239 · see citing works

Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

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Rapid modulation of spine morphology by the 5-HT _2A serotonin receptor through kalirin-7 signaling

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Reelin expression and glycosylation patterns are altered in Alzheimer’s disease

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Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP‐dependent dendritogenesis

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Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

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A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development

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Disappearance of actin‐binding protein, drebrin, from hippocampal synapses in alzheimer's disease

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NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production

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Selective mGluR5 antagonists MPEP and SIB‐1893 decrease NMDA or glutamate‐mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

O’Leary, D. M., Movsesyan, V. A., Vicini, S., & Faden, A. I. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703715 · Cited by 192 · see citing works

Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses

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Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

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Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Hoey, S. E., Williams, R. J., & Perkinton, M. S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.6017-08.2009 · Cited by 178 · see citing works

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

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Loss of brain 5-HT2receptors in Alzheimer's disease

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Insights into the Role of Dopamine Receptor Systems in Learning and Memory

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Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease

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Criteria for Alzheimer's Disease and the Nosology of Dementia with Lewy Bodies

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A Morphological Correlate of Synaptic Scaling in Visual Cortex

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PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

Abbas, A. I., Yadav, P. N., Yao, W.-D., Arbuckle, M. I., Grant, S. G. N., Caron, M. G., & Roth, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1090-09.2009 · Cited by 137 · see citing works

The protein tyrosine kinase, fyn, in Alzheimerʼs disease pathology

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p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

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RICS, a Novel GTPase-activating Protein for Cdc42 and Rac1, Is Involved in the β-Catenin-N-cadherin andN-Methyl-d-aspartate Receptor Signaling

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SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin

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Neurochemical Features of Frontotemporal Dementia

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Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex

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Reduced 5-HT2A receptor binding in patients with mild cognitive impairment

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Characterization of sequential N-cadherin cleavage by ADAM10 and PS1

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PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating

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Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes

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Multiple pathways of apolipoprotein E signaling in primary neurons

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Early Changes in Hippocampal Eph Receptors Precede the Onset of Memory Decline in Mouse Models of Alzheimer's Disease

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Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer’s disease

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Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density

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Differential Changes in Synaptic Proteins in the Alzheimer Frontal Cortex with Marked Increase in PSD-95 Postsynaptic Protein

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