Neurons May Live for Decades with Neurofibrillary Tangles

Tau in physiology and pathology

Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Tau in Alzheimer Disease and Related Tauopathies

Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,121 · see citing works

Neuronal Cell Death

Fricker, M., Tolkovsky, A. M., Borutaitė, V., Coleman, M. P., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,122 · see citing works

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works

Role of tau protein in both physiological and pathological conditions

AVILA, J., LUCAS, J. J., PÉREZ, M., & HERNÁNDEZ, F. (2004) · Physiological Reviews · doi:10.1152/physrev.00024.2003 · Cited by 1,005 · see citing works

The pathological process underlying Alzheimer’s disease in individuals under thirty

Braak, H., & Del Tredici, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0789-4 · Cited by 812 · see citing works

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works

Propagation of Tau aggregates and neurodegeneration

Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632 · see citing works

Mechanisms of tau-induced neurodegeneration

Iqbal, K., Liu, F., Gong, C.-X., Alonso, A. D. C., & Grundke-Iqbal, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0486-3 · Cited by 628 · see citing works

Involvement of oxidative stress in Alzheimer disease

Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611 · see citing works

Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

Alzheimer Disease

Castellani, R. J., Rolston, R. K., & Smith, M. A. (2010) · Disease-a-Month · doi:10.1016/j.disamonth.2010.06.001 · Cited by 561 · see citing works

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

Wang, J., Xia, Y., Grundke, I., & Iqbal, K. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129031 · Cited by 530 · see citing works

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna‐Reeves, C. A., Castillo‐Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R., & Kayed, R. (2012) · The FASEB Journal · doi:10.1096/fj.11-199851 · Cited by 527 · see citing works

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R., & Kayed, R. (2012) · Scientific Reports · doi:10.1038/srep00700 · Cited by 502 · see citing works

The role of tau in neurodegeneration

Gendron, T. F., & Petrucelli, L. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-13 · Cited by 478 · see citing works

Axonal Transport Defects in Neurodegenerative Diseases

Morfini, G. A., Burns, M. R., Binder, L. I., Kanaan, N. M., LaPointe, N. E., Bosco, D. A., Brown, R. H., Brown, H. E., Tiwari, A., Hayward, L. J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3463-09.2009 · Cited by 464 · see citing works

The aging brain: morphomolecular senescence of cortical circuits

Hof, P. R., & Morrison, J. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.013 · Cited by 411 · see citing works

Microtubule-associated protein tau in development, degeneration and protection of neurons

Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 395 · see citing works

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works

Oxidative stress signalling in Alzheimer's disease

Zhu, X., Raina, A. K., Lee, H., Casadesús, G., Smith, M. A., & Perry, G. L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.012 · Cited by 390 · see citing works

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

Braak, H., & Tredici, K. D. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0825-z · Cited by 359 · see citing works

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

Moloney, C. M., Lowe, V. J., & Murray, M. E. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12321 · Cited by 337 · see citing works

The complexity of Alzheimer’s disease: an evolving puzzle

Ferrari, C., & Sorbi, S. (2021) · Physiological Reviews · doi:10.1152/physrev.00015.2020 · Cited by 324 · see citing works

A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

Coleman, P., Federoff, H., & Kurlan, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140626.48118.0a · Cited by 314 · see citing works

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

Zhu, X., Castellani, R. J., Takeda, A., Nunomura, A., Atwood, C., Perry, G. L., & Smith, M. A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00342-6 · Cited by 309 · see citing works

Current Advances on Different Kinases Involved in Tau Phosphorylation, and Implications in Alzheimers Disease and Tauopathies

Ferrer, I., Gómez‐Isla, T., Puig, B., Freixes, M., Ribé, E. M., Dalfó, E., & Ávila, J. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772713 · Cited by 302 · see citing works

Alzheimer disease, the two-hit hypothesis: An update

Zhu, X., Lee, H., Perry, G. L., & Smith, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.014 · Cited by 292 · see citing works

GSK3: a possible link between beta amyloid peptide and tau protein

Hernández, F., Gómez de Barreda, E., Fuster-Matanzo, A., Lucas, J. J., & Avila, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.011 · Cited by 327 · see citing works

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer's Disease

LeBlanc, A. C., Liu, H., Goodyer, C. G., Bergeron, C., & Hammond, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23426 · Cited by 279 · see citing works

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Estes, D. M., Barrett, A. D. T., Dineley, K. T., Jackson, G. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3192-13.2014 · Cited by 278 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

Kanaan, N. M., Morfini, G. A., LaPointe, N. E., Pigino, G. F., Patterson, K. R., Song, Y., Andreadis, A., Fu, Y., Brady, S. T., & Binder, L. I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0560-11.2011 · Cited by 273 · see citing works

Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer's Disease

Mosch, B., Morawski, M., Mittag, A., Lenz, D., Tárnok, A., & Arendt, T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0379-07.2007 · Cited by 271 · see citing works

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

Braak, H., & Tredici, K. D. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835a3432 · Cited by 252 · see citing works

Alzheimer Disease, a Multifactorial Disorder Seeking Multi-therapies

Iqbal, K., & Grundke-Iqbal, I. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.04.006 · Cited by 231 · see citing works

Tau oligomers and tau toxicity in neurodegenerative disease

Ward, S., Himmelstein, D. S., Lancia, J. K., & Binder, L. I. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120134 · Cited by 244 · see citing works

Extracellular tau is toxic to neuronal cells

Gómez-Ramos, A., Díaz-Hernández, M., Cuadros, R., Hernández, F., & Avila, J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.078 · Cited by 241 · see citing works

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

Lee, H., Perry, G. L., Moreira, P. I., Garrett, M. R., Liu, Q., Zhu, X., Takeda, A., Nunomura, A., & Smith, M. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.02.008 · Cited by 240 · see citing works

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

Ehrenberg, A. J., Nguy, A. K., Theofilas, P., Dunlop, S. R., Suemoto, C. K., Alho, A. T. D. L., Leite, R. P., Rodriguez, R. D., Mejia, M. B., Rüb, U., et al. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12387 · Cited by 240 · see citing works

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239 · see citing works

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

Gaikwad, S., Puangmalai, N., Bittar, A., Montalbano, M., Garcia, S., McAllen, S., Bhatt, N., Sonawane, M., Sengupta, U., & Kayed, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109419 · Cited by 234 · see citing works

Neuronal cell death mechanisms in Alzheimer’s disease: An insight

Goel, P., Chakrabarti, S., Goel, K., Bhutani, K., Chopra, T., & Bali, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937133 · Cited by 235 · see citing works

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections

Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1458-4 · Cited by 223 · see citing works

Cellular and pathological heterogeneity of primary tauopathies

Chung, D. C., Roemer, S. F., Petrucelli, L., & Dickson, D. W. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00476-x · Cited by 218 · see citing works

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation

Kuusisto, E., Salminen, A., & Alafuzoff, I. I. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00394.x · Cited by 213 · see citing works

The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease

Bailey, T. L., Rivara, C. B., Rocher, A. B., & Hof, P. R. (2004) · Neurological Research · doi:10.1179/016164104225016272 · Cited by 213 · see citing works

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works

Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease

Yao, P. J., Zhu, M., Pyun, E. I., Brooks, A. I., Therianos, S., Meyers, V. E., & Coleman, P. D. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00009-8 · Cited by 205 · see citing works

The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆

Finch, C. E., & Sapolsky, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00053-6 · Cited by 204 · see citing works

Are tau aggregates toxic or protective in tauopathies?

Cowan, C. M., & Mudher, A. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00114 · Cited by 215 · see citing works

Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert

Sassin, I., Schultz, C., Thal, D. R., Rüb, U., Arai, K., Braak, E., & Braak, H. (2000) · Acta Neuropathologica · doi:10.1007/s004019900178 · Cited by 193 · see citing works

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Kril, J., Patel, S., Harding, A., & Halliday, G. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0477-5 · Cited by 190 · see citing works

Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain

Smith, M. A., Casadesús, G., Joseph, J. A., & Perry, G. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01021-3 · Cited by 189 · see citing works

Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9

Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185 · see citing works

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

Castillo‐Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero‐Munoz, M. J., Lasagna‐Reeves, C. A., & Kayed, R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132477 · Cited by 180 · see citing works

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

Su, B., Wang, X., Lee, H., Tabaton, M., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.010 · Cited by 178 · see citing works

Alzheimer disease pathology as a host response

Castellani, R. J., Lee, H.-G., Zhu, X., Perry, G., & Smith, M. A. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318177eaf4 · Cited by 171 · see citing works

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

Nilson, A. N., English, K. C., Gerson, J. E., Whittle, T. B., Crain, C. N., Xue, J. J., Sengupta, U., Castillo‐Carranza, D. L., Zhang, W., Gupta, P. K., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160912 · Cited by 170 · see citing works

Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo

Guillozet-Bongaarts, A. L., Cahill, M. E., Cryns, V. L., Reynolds, M. R., Berry, R. W., & Binder, L. I. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03784.x · Cited by 169 · see citing works

Cell death mechanisms in neurodegeneration

Jellinger, K. A. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00134.x · Cited by 166 · see citing works

Triggers of Full-Length Tau Aggregation: A Role for Partially Folded Intermediates

Chirita, C. N., Congdon, E. E., Yin, H., & Kuret, J. (2005) · Biochemistry · doi:10.1021/bi0500123 · Cited by 166 · see citing works

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

Koper, M. J., Schoor, E. V., Ospitalieri, S., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Tousseyn, T., Balusu, S., Strooper, B. D., & Thal, D. R. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02103-y · Cited by 164 · see citing works

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Chiasseu, M., Alarcón-Martínez, L., Belforte, N., Quintero, H., Dotigny, F., Destroismaisons, L., Velde, C. V., Panayi, F., Louis, C., & Polo, A. D. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0199-3 · Cited by 158 · see citing works

Recent developments in the pathology of Parkinson’s disease

Jellinger, K. A. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_33 · Cited by 154 · see citing works

Abortive apoptosis in Alzheimer's disease

Raina, A. K., Hochman, A., Zhu, X., Rottkamp, C. A., Nunomura, A., Siedlak, S. L., Boux, H. A., Castellani, R. J., Perry, G. L., & Smith, M. A. (2001) · Acta Neuropathologica · doi:10.1007/s004010100378 · Cited by 153 · see citing works

Metabolic, Metallic, and Mitotic Sources of Oxidative Stress in Alzheimer Disease

Smith, M. A., Nunomura, A., Zhu, X., Takeda, A., & Perry, G. L. (2000) · Antioxidants and Redox Signaling · doi:10.1089/15230860050192198 · Cited by 151 · see citing works

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

Koss, D. J., Jones, G., Cranston, A., Gardner, H., Kanaan, N. M., & Platt, B. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1632-3 · Cited by 149 · see citing works

Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

Braak, H., & Del Tredici, K. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy152 · Cited by 148 · see citing works

Disentangling the Relationship between Lewy Bodies and Nigral Neuronal Loss in Parkinson's Disease

Parkkinen, L., O’Sullivan, S. S., Collins, C., Petrie, A., Holton, J. L., Révész, T., & Lees, A. J. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11046 · Cited by 148 · see citing works

Rapid Accumulation of Endogenous Tau Oligomers in a Rat Model of Traumatic Brain Injury

Hawkins, B. E., Krishnamurthy, S., Castillo‐Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S., & Kayed, R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.472746 · Cited by 148 · see citing works

Oxidative Imbalance in Alzheimer's Disease

Zhu, X., Lee, H., Casadesús, G., Ávila, J., Drew, K. L., Perry, G. L., & Smith, M. A. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:205 · Cited by 146 · see citing works

Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?

Swerdlow, R. H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.021 · Cited by 144 · see citing works

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A.-L., & Kent, T. A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101716 · Cited by 142 · see citing works

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

Braak, H., Zetterberg, H., Tredici, K. D., & Blennow, K. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1139-0 · Cited by 141 · see citing works

Cell-to-Cell Transmission of Tau and α-Synuclein

Uemura, N., Uemura, M. T., Luk, K. C., Lee, V. M. ‐., & Trojanowski, J. Q. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.012 · Cited by 141 · see citing works

Formation and Propagation of Tau Oligomeric Seeds

Gerson, J. E., & Kayed, R. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00093 · Cited by 137 · see citing works

Metal ions and oxidative protein modification in neurological disease.

Sayre, L. M., Moreira, P. I., Smith, M. A., & Perry, G. L. (2005) · PubMed · Cited by 135 · see citing works

Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues

Samudra, N. P., Lane‐Donovan, C., VandeVrede, L. A., & Boxer, A. L. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168553 · Cited by 134 · see citing works

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

Castellani, R. J., Lee, H., Zhu, X., Nunomura, A., Perry, G. L., & Smith, M. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0071-y · Cited by 133 · see citing works

Tau Oligomers Neurotoxicity

Niewiadomska, G., Niewiadomski, W., Steczkowska, M., & Gąsiorowska, A. (2021) · Life · doi:10.3390/life11010028 · Cited by 132 · see citing works

Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology

Moreira, P. I., Honda, K., Liu, Q., Santos, M. S., Oliveira, C. R., Aliev, G. M., Nunomura, A., Zhu, X., Smith, M. A., & Perry, G. L. (2005) · Current Alzheimer Research · doi:10.2174/156720505774330537 · Cited by 129 · see citing works

Aluminum’s Involvement in the Progression of Alzheimer’s Disease

Walton, J. R. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121909 · Cited by 127 · see citing works

Microglia in Alzheimer’s Disease in the Context of Tau Pathology

Perea, J. R., Bolós, M., & Ávila, J. (2020) · Biomolecules · doi:10.3390/biom10101439 · Cited by 127 · see citing works

Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro

Ksiȩżak-Reding, H., Pyo, H. K., Feinstein, B., & Pasinetti, G. M. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.09.001 · Cited by 127 · see citing works

General aspects of neurodegeneration

Jellinger, K. A. (2003) · Journal of Neural Transmission. Supplementa · doi:10.1007/978-3-7091-0643-3_7 · Cited by 126 · see citing works

Pathways of tau fibrillization

Kuret, J., Chirita, C. N., Congdon, E. E., Kannanayakal, T. J., Li, G., Necula, M., Yin, H., & Zhong, Q. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.016 · Cited by 124 · see citing works

Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality Criteria

Walton, J. R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132204 · Cited by 124 · see citing works

Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease

Bussire, T., Gold, G., Kvari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00942-9 · Cited by 122 · see citing works

Therapeutic Strategies for Alzheimer’s Disease

Barten, D. M., & Albright, C. F. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8031-2 · Cited by 122 · see citing works

The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology

Cárdenas-Aguayo, M. D. C., Gómez-Virgilio, L., DeRosa, S., & Meraz-Ríos, M. A. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500148z · Cited by 120 · see citing works

The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Blair, L. J., Baker, J. D., Sabbagh, J. J., & Dickey, C. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13033 · Cited by 120 · see citing works

New perspectives on the role of tau in Alzheimer's disease. Implications for therapy

Medina, M., & Ávila, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.013 · Cited by 118 · see citing works

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117 · see citing works

Posttranslational modifications of α-tubulin in alzheimer disease

Zhang, F., Su, B., Wang, C., Siedlak, S. L., Mondragón‐Rodríguez, S., Lee, H., Wang, X., Perry, G. L., & Zhu, X. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0030-4 · Cited by 116 · see citing works

Autophagy–lysosomal-associated neuronal death in neurodegenerative disease

Nixon, R. A. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02799-7 · Cited by 117 · see citing works

Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Bobinski, M., Węgiel, J., Tarnawski, M. J., Bobinski, M., de Leon, M. J., Reisberg, ‌., Miller, D. C., & Wı́sniewski, H. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00441-7 · Cited by 38 · see citing works

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Kril, J., Patel, S., Harding, A., & Halliday, G. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0477-5 · Cited by 190 · see citing works

On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam

Schwab, C., Schulzer, M., Steele, J. C., & McGeer, P. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00005-6 · Cited by 24 · see citing works

Stereologic Evidence for Persistence of Viable Neurons in Layer II of the Entorhinal Cortex and the CA1 Field in Alzheimer Disease

Hof, P. R., Bussière, T., Gold, G., Kövari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., & Morrison, J. H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.1.55 · Cited by 85 · see citing works

Neuronal loss and neurofibrillary degeneration in the hippocampal cortex in late-onset sporadic Alzheimer’s disease

Fukutani, Y., Cairns, N. J., Shiozawa, M., Sasaki, K., Sudo, S., Isaki, K., & Lantos, P. L. (2000) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2000.00747.x · Cited by 70 · see citing works