The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory
Abstract
We investigated the effects of acute adrenal steroid treatment on spatial memory using the Y-maze and employing adrenal steroid receptor antagonists and agonists. For receptor activation, adrenalectomized rats were injected 2 h prior to their first Y-maze trial with sesame oil (adrenalectomy or SHAM), stress levels of corticosterone, a Type I receptor agonist (aldosterone), or a Type II receptor agonist (RU362). For receptor inactivation, unoperated rats were injected with a Type I receptor antagonist (RU318), a Type II receptor antagonist (RU555), sesame oil, or not injected at all. The findings indicated that spatial memory was impaired when the Type II receptors were blocked (RU555) or highly occupied (corticosterone or RU362) and normal for the other treatment conditions. These data suggest that the Type II receptors may be responsible for the inverted U-shaped relationship between spatial memory and corticosterone levels reported by others.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76]; Kuhlmann et al. [166]; Kuhlmann et al. [167]; Payne et al. [168]; Buchanan”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Conrad et al. [158]
Citations
Cites
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024
Self-citationBrain corticosteroid receptor balance and homeostatic control
de Kloet, E. R. (1991) · Frontiers in Neuroendocrinology · Cited by 842
Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 805
Self-citationDiamond, D. M., Bennett, M. C., Fleshner, M., & Rose, G. M. (1992) · Hippocampus · doi:10.1002/hipo.450020409 · Cited by 688
Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.
Oitzl, M. S., & de Kloet, E. R. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.62 · Cited by 649
A two-trial memory task with automated recording: study in young and aged rats
Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91352-f · Cited by 390
Steroid Hormones and Excitability in the Mammalian Brain
Joëls, M. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0144 · Cited by 284
Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation
Pavlides, C., Watanabe, Y., Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00151-8 · Cited by 261
Self-citationYau, J. L. W., Olsson, T., Morris, R., Meaney, M. J., & Seckl, J. R. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00612-9 · Cited by 175
Corticosteroid Receptor Antagonists are Amnestic for Passive Avoidance Learning in Day‐old Chicks
Sandi, C., & Rose, S. P. R. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00319.x · Cited by 138
Conrad, C. D., LUPIEN, S. J., Thanasoulis, L. C., & McEwen, B. S. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00236-9 · Cited by 134
Self-citationHippocampal homosynaptic long-term depression/depotentiation induced by adrenal steroids
Pavlides, C., Kimura, A., Magarin˜os, A. M., & Mcewen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)94332-s · Cited by 126
Self-citationCorticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons
Karst, H., Wadman, W. J., & Joëls, M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91069-3 · Cited by 119
Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory
Conrad, C. D., & Roy, E. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02582.1993 · Cited by 116
Self-citationKerr, D. S., Huggett, A. M., & Abraham, W. C. (1994) · Psychobiology · doi:10.3758/bf03327090 · Cited by 98
Coussens, C. M., Kerr, D. S., & Abraham, W. C. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.1.1 · Cited by 96
Mains, R. E., Myers, A. C., & Eipper, B. A. (1985) · Endocrinology · doi:10.1210/endo-116-6-2505 · Cited by 69
McCormick, C. M., McNamara, M., Mukhopadhyay, S., & Kelsey, J. E. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.3.518 · Cited by 47
YOUGUE, B., & Roy, E. J. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90157-x · Cited by 9
Hesen, W., & Joëls, M. (1995) · Synapse · doi:10.1002/syn.890200403 · Cited by 6
Flagged first, then by citations
Cited by
Sorted by citations
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Mood disorders and allostatic load
McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135
Self-citationKorte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097
Self-citationStress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
Roozendaal, B. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4080 · Cited by 838
Metadata
- Authors
- Conrad, C. D., Lupien, S. J., & McEwen, B. S.
- Affiliations
- Arizona State University (US)
- Douglas Mental Health University Institute (CA)
- Rockefeller University (US)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 72
- Issue
- 1
- Pages
- 39-46
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2026986199
- Cited by
- 199
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32mh010804-02)
- National Institute of Mental Health (MH-41256, MH10804)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- spatial memory, corticosterone, aldosterone, adrenalectomy, Y-maze, inverted U-shaped relationship, glucocorticoid receptor antagonist
- MeSH terms
- Adrenalectomy, Aldosterone, Mineralocorticoid Receptor Antagonists, Analysis of Variance, Androstanols, Animals, Corticosterone, Hippocampus, Male, Memory, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Receptors, Mineralocorticoid, Maze Learning, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
