Cited by 199Memory and Neural MechanismsStress Responses and CortisolAdrenal Hormones and Disorders

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Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory

Conrad, Cheryl D., Lupien, Sonia J., McEwen, Bruce S.·1999·Neurobiology of Learning and Memory

DOI 10.1006/nlme.1998.3898

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Abstract

We investigated the effects of acute adrenal steroid treatment on spatial memory using the Y-maze and employing adrenal steroid receptor antagonists and agonists. For receptor activation, adrenalectomized rats were injected 2 h prior to their first Y-maze trial with sesame oil (adrenalectomy or SHAM), stress levels of corticosterone, a Type I receptor agonist (aldosterone), or a Type II receptor agonist (RU362). For receptor inactivation, unoperated rats were injected with a Type I receptor antagonist (RU318), a Type II receptor antagonist (RU555), sesame oil, or not injected at all. The findings indicated that spatial memory was impaired when the Type II receptors were blocked (RU555) or highly occupied (corticosterone or RU362) and normal for the other treatment conditions. These data suggest that the Type II receptors may be responsible for the inverted U-shaped relationship between spatial memory and corticosterone levels reported by others.

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Authors: Conrad, C. D., Lupien, S. J., & McEwen, B. S.
Affiliations: Arizona State University (US)
Douglas Mental Health University Institute (CA)
Rockefeller University (US)
ORCID: Conrad, Cheryl D.
Lupien, Sonia J.
McEwen, Bruce S.
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 1999-07
Volume: 72
Issue: 1
Pages: 39-46
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1006/nlme.1998.3898
OpenAlex: W2026986199
Cited by: 199
References: 21
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
FWCI: 4.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f32mh010804-02)
National Institute of Mental Health (MH-41256, MH10804)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: spatial memory, corticosterone, aldosterone, adrenalectomy, Y-maze, inverted U-shaped relationship, glucocorticoid receptor antagonist
MeSH terms: Adrenalectomy, Aldosterone, Mineralocorticoid Receptor Antagonists, Analysis of Variance, Androstanols, Animals, Corticosterone, Hippocampus, Male, Memory, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Receptors, Mineralocorticoid, Maze Learning, Rats

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Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory

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