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HPV16 E6 oncoprotein inhibits apoptosis induced during serum-calcium differentiation of foreskin human keratinocytes

Alfandari, Jacklin, Shnitman Magal, Sharon, Jackman, Anna, Schlegel, Richard, Gonen, Pinhas, Sherman, Levana·1999·Virology

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  1. Blanton, 1992, Expression of the HPV16 E7 gene generates proliferation in stratified squamous cell cultures which is independent of endogenous p53 levels, Cell Growth Differ., 3, 791
  2. Boyce, 1983, Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal cultures and serum free serial cultures, J. Invest. Dermatol., 81, 33, 10.1111/1523-1747.ep12540422 · DOI
  3. Cheng, 1995, Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes, Genes Dev., 9, 2335, 10.1101/gad.9.19.2335 · DOI
  4. Darzynkiewicz, 1992, Features of apoptotic cells measured by flow cytometry, Cytometry, 13, 808, 10.1002/cyto.990130802 · DOI
  5. Demers, 1996, Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation, J. Virol., 70, 6862, 10.1128/jvi.70.10.6862-6869.1996 · DOI
  6. Fernandez-Sarabia, 1993, Bcl-2 associates with the ras-related protein R-ras p23, Nature, 366, 274, 10.1038/366274a0 · DOI
  7. Foster, 1994, The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest, J. Virol., 68, 5698, 10.1128/jvi.68.9.5698-5705.1994 · DOI · Paper page
  8. Frisch, 1994, Disruption of epithelial cell–matrix interactions induces apoptosis, J. Cell. Biol., 124, 619, 10.1083/jcb.124.4.619 · DOI
  9. Frisch, 1997, Integrins and anoikis, Curr. Opin. Cell Biol., 9, 701, 10.1016/S0955-0674(97)80124-X · DOI
  10. Fuchs, 1995, Keratins and the skin, Annu. Rev. Cell Dev. Biol., 11, 123, 10.1146/annurev.cb.11.110195.001011 · DOI
  11. Fuchs, 1994, The epidermis: Rising to the surface, Curr. Opin. Genet. Dev., 4, 725, 10.1016/0959-437X(94)90140-X · DOI
  12. Gavrieli, 1992, Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J. Cell Biol., 119, 493, 10.1083/jcb.119.3.493 · DOI · Paper page
  13. Haake, 1993, Cell death by apoptosis in epidermal biology, J. Invest. Dermatol., 101, 107, 10.1111/1523-1747.ep12363594 · DOI
  14. Halbert, 1992, The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells, J. Virol., 66, 2125, 10.1128/jvi.66.4.2125-2134.1992 · DOI · Paper page
  15. Han, 1996, The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein, Genes Dev., 10, 461, 10.1101/gad.10.4.461 · DOI
  16. Hawley-Nelson, 1989, HPV-16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes, EMBO J., 8, 3905, 10.1002/j.1460-2075.1989.tb08570.x · DOI · Paper page
  17. Hennings, 1980, Calcium regulation of growth and differentiation of mouse epidermal cells in culture, Cell, 19, 245, 10.1016/0092-8674(80)90406-7 · DOI
  18. Hudson, 1990, Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18, J. Virol., 64, 519, 10.1128/jvi.64.2.519-526.1990 · DOI · Paper page
  19. Jian, 1998, Post-transcriptional induction of p21cip1 protein by human papillomavirus E7 inhibits unscheduled DNA synthesis reactivated in differentiated keratinocytes, Oncogene, 17, 2027, 10.1038/sj.onc.1202142 · DOI · Paper page
  20. Jones, 1997, The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21 CiP1 mediated inhibition of cdk2, Genes Dev., 11, 2101, 10.1101/gad.11.16.2101 · DOI · Paper page
  21. Jordan, 1996, Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity, Oral Oncol. Eur. J. Cancer, 32B, 394, 10.1016/S0964-1955(96)00033-4 · DOI
  22. Kelekar, 1998, Bcl-2 family proteins: The roles of the BH3 domain in apoptosis, Trends Cell. Biol., 8, 324, 10.1016/S0962-8924(98)01321-X · DOI
  23. Kikuchi, 1997, Time correlation of commitment to calcium-induced apoptosis and terminal differentiation in human ectocervical keratinocytes in suspension cultures, Cell Growth Differ., 8, 571
  24. Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
  25. Lu, 1993, Bcl-2 expression in adult and embryonic non-haematopoietic tissues, J. Pathol., 169, 431, 10.1002/path.1711690408 · DOI
  26. Marthinuss, 1995, Apoptosis in Pam 212, an epidermal keratinocyte cell line: A possible role for bcl-2 in epidermal differentiation, Cell Growth Differ., 6, 239
  27. Maruoka, 1997, Keratinocytes become terminally differentiated in a process involving programmed cell death, Biochem. Biophys. Res. Commun., 238, 886, 10.1006/bbrc.1997.7405 · DOI
  28. McCall, 1991, Programmed cell death in terminally differentiating keratinocytes: Role of endogenous endonuclease, J. Invest. Dermatol., 97, 111, 10.1111/1523-1747.ep12478519 · DOI
  29. Meredith, 1993, The extracellular matrix as a cell survival factor, Mol. Biol. Cell, 4, 953, 10.1091/mbc.4.9.953 · DOI
  30. Missero, 1995, Involvement of the cell-cycle inhibitor Cip/WAF1 and the E1A-associated p300 protein in terminal differentiation, Proc. Natl. Acad. Sci. USA, 92, 5451, 10.1073/pnas.92.12.5451 · DOI
  31. Mitra, 1997, Apoptosis in keratinocytes is not dependent on induction of differentiation, Lab. Invest., 76, 99
  32. Moll, 1982, The catalog of human cytokeratins patterns of expression in normal epithelia, tumors and cultured cells, Cell, 31, 11, 10.1016/0092-8674(82)90400-7 · DOI
  33. Munger, 1989, The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes, J. Virol., 63, 4417, 10.1128/jvi.63.10.4417-4421.1989 · DOI · Paper page
  34. Pan, 1995, Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development, Genes Dev., 9, 2157, 10.1101/gad.9.17.2157 · DOI
  35. Pei, 1998, HPV16 E7 protein bypasses keratinocyte growth inhibition by serum and calcium, Carcinogenesis, 19, 1481, 10.1093/carcin/19.8.1481 · DOI
  36. Pirisi, 1988, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA, Carcinogenesis, 1573, 10.1093/carcin/9.9.1573 · DOI
  37. Pittelkow, 1986, Two functionally distinct classes of growth arrest states in human prokeratinocytes that regulate clonogenic potential, J. Invest. Dermatol., 86, 410, 10.1111/1523-1747.ep12285684 · DOI
  38. Polakowska, 1994, Apoptosis in human skin development: Morphogenesis periderm and stem cells, Dev. Dyn., 199, 176, 10.1002/aja.1001990303 · DOI
  39. Quinlain, 1995, Intermediate filament proteins, Protein Profile, 2, 801
  40. Rodriguez-Villanueva, 1995, The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers, Path. Res. Pract., 191, 391, 10.1016/S0344-0338(11)80724-7 · DOI
  41. Ruoslahti, 1994, Anchorage dependence, integrins, and apoptosis, Cell, 177, 477, 10.1016/0092-8674(94)90209-7 · DOI
  42. Sarid, 1997, Kaposi's sarcoma associated herpes virus encodes a functional Bcl-2 homologue, Nat. Med., 3, 293, 10.1038/nm0397-293 · DOI
  43. Scheffner, 1990, The E6 oncoproteins encoded by human papillomavirus types 16 and 18 promote the degradation of p53, Cell, 63, 1129, 10.1016/0092-8674(90)90409-8 · DOI · Paper page
  44. Schlegel, 1988, Quantitative keratinocyte assay detects two biological activities of human papillomavirus and identifies viral types associated with cervical carcinoma, EMBO J., 7, 3181, 10.1002/j.1460-2075.1988.tb03185.x · DOI · Paper page
  45. Sherman, 1996, Serum- and calcium-induced differentiation of human keratinocytes is inhibited by HPV16 E6 oncoprotein, J. Virol., 70, 3269, 10.1128/jvi.70.5.3269-3279.1996 · DOI
  46. Sherman, 1997, Inhibition of serum and calcium-induced differentiation of human keratinocytes by HPV16 E6 oncoprotein: Role of p53 inactivation, Virology, 237, 296, 10.1006/viro.1997.8778 · DOI
  47. Shino, 1995, Human papillomavirus type 16 E6 protein transcriptionally modulates fibronectin gene expression by induction of protein complexes binding to the cyclic AMP response element, J. Virol., 71, 4310, 10.1128/jvi.71.6.4310-4318.1997 · DOI
  48. Shnitman Magal, 1998, Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins, Int. J. Cancer, 75, 96, 10.1002/(SICI)1097-0215(19980105)75:1<96::AID-IJC15>3.0.CO;2-B · DOI
  49. Steller, 1996, Transformation by human papillomavirus 16 E6 and E7: Role of the insulin-like growth factor 1 receptor, Cancer Res., 56, 5087
  50. Teodoro, 1997, Regulation of apoptosis by viral gene products, J. Virol., 71, 1739, 10.1128/jvi.71.3.1739-1746.1997 · DOI
  51. Thomas, 1998, Inhibition of Bak-induced apoptosis by HPV-18 E6, Oncogene, 17, 2943, 10.1038/sj.onc.1202223 · DOI · Paper page
  52. Thomas, 1996, Induction of apoptosis by p53 is independent of its oligomeric state and can be abolished by HPV-18 E6 through ubiquitin mediated degradation, Oncogene, 13, 265
  53. Tong, 1997, The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton, Proc. Natl. Acad. Sci. USA, 94, 4412, 10.1073/pnas.94.9.4412 · DOI
  54. Vousden, 1994, Interactions between papillomavirus proteins and tumor suppressor gene products, Adv. Cancer Res., 64, 1, 10.1016/S0065-230X(08)60833-7 · DOI
  55. Vousden, 1995, Regulation of the cell cycle by viral oncoproteins, Semin. Cancer Biol., 6, 109, 10.1006/scbi.1995.0014 · DOI
  56. Watt, 1989, Terminal differentiation of epidermal keratinocytes, Curr. Opin. Cell Biol., 1, 1107, 10.1016/S0955-0674(89)80058-4 · DOI
  57. White, 1994, Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by HPV oncoproteins, Gene Dev., 8, 666, 10.1101/gad.8.6.666 · DOI
  58. Woodworth, 1988, Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus type 16 and 18 DNA, Cancer Res., 48, 4620
  59. Woodworth, 1992, Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection, Oncogene, 7, 619
  60. Woodworth, 1993, Over expression of wild type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus expressing cell lines, Cell Growth Differ., 4, 367
  61. Yang, 1996, Molecular thanatopsis: A discourse on the Bcl2 family and cell death, Blood, 88, 386, 10.1182/blood.V88.2.386.bloodjournal882386 · DOI
  62. Zur-Hausen, 1996, Papillomavirus infection—A major cause of human cancers, Biochim. Biophys. Acta, 1288, F55

Metadata

Authors
Alfandari, J., Shnitman Magal, S., Jackman, A., Schlegel, R., Gonen, P., & Sherman, L.
Venue
Virology
Publisher
Elsevier BV
Published
1999-05
Volume
257
Issue
2
Pages
383-396
ISSN
0042-6822
Cited by
37
References
1
Language
en

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CoChat. (2026). Citation check: HPV16 E6 oncoprotein inhibits apoptosis induced during serum-calcium differentiation of foreskin human keratinocytes. https://app.cochat.ai/papers/10.1006/viro.1999.9675
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Alfandari, J., Shnitman Magal, S., Jackman, A., Schlegel, R., Gonen, P., & Sherman, L. (1999). HPV16 E6 oncoprotein inhibits apoptosis induced during serum-calcium differentiation of foreskin human keratinocytes. Virology. https://doi.org/10.1006/viro.1999.9675