Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering

Chitin and chitosan: Properties and applications

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Chitosan Chemistry and Pharmaceutical Perspectives

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Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers

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Biodegradation, biodistribution and toxicity of chitosan

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Gene therapy - promises, problems and prospects

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Porous chitosan scaffolds for tissue engineering

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Chitosan and its derivatives for tissue engineering applications

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Novel injectable neutral solutions of chitosan form biodegradable gels in situ

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Chitosan and Its Use as a Pharmaceutical Excipient

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Chitosan-modifications and applications: Opportunities galore

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In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers

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Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering

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Antibacterial action of chitosan

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Chitosan-based formulations for delivery of DNA and siRNA

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Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review

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Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties

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Targeted delivery of low molecular drugs using chitosan and its derivatives

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Evaluation of the biocompatibility of a chitosan scaffold in mice

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Chemically modified chitin and chitosan as biomaterials

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PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release

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Development and characterisation of chitosan nanoparticles for siRNA delivery

Katas, H., & Alpar, H. O. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.07.021 · Cited by 642

RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System

Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.04.010 · Cited by 585

Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability

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Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

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Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

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Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride

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The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing

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Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency

Kean, T., Roth, S., & Thanou, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.01.001 · Cited by 389

A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel

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Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice

Kim, J.-H., Kim, Y.-S., Park, K., Lee, S., Nam, H. Y., Min, K. H., Jo, H. G., Park, J. H., Choi, K., Jeong, S. Y., et al. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.014 · Cited by 350

Thermosensitive chitosan–Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration

Park, K. M., Lee, S. Y., Joung, Y. K., Na, J. S., Lee, M. C., & Park, K. D. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.01.040 · Cited by 346

Characterization of thermosensitive chitosan gels for the sustained delivery of drugs

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Hydrophobic derivatives of chitosan: Characterization and rheological behaviour

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Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering

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In vitro degradation rates of partially N-acetylated chitosans in human serum

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Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel

Kim, J.-H., Kim, Y.-S., Kim, S., Park, J. H., Kim, K., Choi, K., Chung, H., Jeong, S. Y., Park, R.-W., Kim, I.-S., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.013 · Cited by 313

Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery

Csaba, N., Köping-Höggård, M., & Alonso, M. J. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.07.028 · Cited by 307

Gel characterisation and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan

Sung, J. H., Hwang, M.-R., Kim, J. O., Lee, J. H., Kim, Y. I., Kim, J. H., Chang, S. W., Jin, S. G., Kim, J. A., & Lyoo, W. S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.03.024 · Cited by 299

Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials

Lee, J.-Y., Nam, S.-H., Im, S.-Y., Park, Y.-J., Lee, Y.-M., Seol, Y.-J., Chung, C.-P., & Lee, S.-J. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00498-9 · Cited by 298

Chitosan Amphiphilic Derivatives. Chemistry and Applications

Aranaz, I., Harris, R., & Heras, A. (2010) · Current Organic Chemistry · doi:10.2174/138527210790231919 · Cited by 294

Chitosan-graft-polyethylenimine as a gene carrier

Jiang, H.-L., Kim, Y.-K., Arote, R., Nah, J.-W., Cho, M.-H., Choi, Y.-J., Akaike, T., & Cho, C.-S. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.025 · Cited by 289

Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles

Han, H. D., Mangala, L. S., Lee, J. W., Shahzad, M. M. K., Kim, H. S., Shen, D., Nam, E. J., Mora, E. M., Stone, R. L., Lu, C., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0005 · Cited by 282

Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles

Park, K., Kim, J.-H., Nam, Y. S., Lee, S., Nam, H. Y., Kim, K., Park, J. H., Kim, I.-S., Choi, K., Kim, S. Y., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.009 · Cited by 257

Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers

Thanou, M. M., Kotzé, A. F., Scharringhausen, T., Lueßen, H. L., de Boer, A. G., Verhoef, J. C., & Junginger, H. E. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00131-5 · Cited by 254

Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles

Hwang, H.-Y., Kim, I.-S., Kwon, I. C., & Kim, Y.-H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.02.003 · Cited by 254

A chitosan/β-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer

Kim, S., Nishimoto, S. K., Bumgardner, J. D., Haggard, W. O., Gaber, M. W., & Yang, Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.139 · Cited by 247

Nucleic acid delivery with chitosan and its derivatives

Lai, W.-F., & Lin, M. C.-M. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.021 · Cited by 241

Water-Soluble and Low Molecular Weight Chitosan-Based Plasmid DNA Delivery

Lee, M., Nah, J.-W., Kwon, Y., Koh, J. J., Ko, K. S., & Kim, S. W. (2001) · Pharmaceutical Research · doi:10.1023/a:1011037807261 · Cited by 240

Effect of chitosan molecular weight and deacetylation degree on hemostasis

Yang, J., Tian, F., Wang, Z., Wang, Q., Zeng, Y., & Chen, S. (2008) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.30853 · Cited by 234

Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption

Rekha, M. R., & Sharma, C. P. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.01.011 · Cited by 216

Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan

Verheul, R. J., Amidi, M., van der Wal, S., van Riet, E., Jiskoot, W., & Hennink, W. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.05.026 · Cited by 206

Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing

Minagawa, T., Okamura, Y., Shigemasa, Y., Minami, S., & Okamoto, Y. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.07.007 · Cited by 177

Wet chemical synthesis of chitosan hydrogel–hydroxyapatite composite membranes for tissue engineering applications

Madhumathi, K., Shalumon, K. T., Rani, V. V. D., Tamura, H., Furuike, T., Selvamurugan, N., Nair, S. V., & Jayakumar, R. (2009) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.03.011 · Cited by 174

Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug

Huo, M., Zhang, Y., Zhou, J., Zou, A., Yu, D., Wu, Y., Li, J., & Li, H. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.05.001 · Cited by 168

Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone

Moreira, C., Oliveira, H., Pires, L. R., Simões, S., Barbosa, M. A., & Pêgo, A. P. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.04.021 · Cited by 160

The controlling biodegradation of chitosan fibers by N-acetylation in vitro and in vivo

Yang, Y. M., Hu, W., Wang, X. D., & Gu, X. S. (2007) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-007-3013-x · Cited by 159

New Drug Delivery Systems Based on Chitosan

Paños, I., Acosta, N., & Heras, Á. (2008) · Current Drug Discovery Technologies · doi:10.2174/157016308786733528 · Cited by 152

Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system

Zhang, C., Qineng, P., & Zhang, H. (2004) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.09.002 · Cited by 150

Aggregation phenomenon of PEG-grafted chitosan in aqueous solution

Ouchi, T., Nishizawa, H., & Ohya, Y. (1998) · Polymer · doi:10.1016/s0032-3861(97)10020-9 · Cited by 149

Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers

Gorochovceva, N., & Makuška, R. (2004) · European Polymer Journal · doi:10.1016/j.eurpolymj.2003.12.005 · Cited by 144

Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin

Hu, F., Wu, X., Du, Y., You, J., & Yuan, H. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.09.018 · Cited by 142

Chitosan microparticles containing plasmid DNA as potential oral gene delivery system

GULIYEVA, U., Öner, F., Özsoy, Ş. Y., & Haziroglu, R. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2005.08.006 · Cited by 141

Preparation of N-alkyl-O-sulfate chitosan derivatives and micellar solubilization of taxol

Zhang, C., Ping, Q., Zhang, H., & Shen, J. (2003) · Carbohydrate Polymers · doi:10.1016/s0144-8617(03)00090-0 · Cited by 134

Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin

Du, Y., Wang, L., Yuan, H., Wei, X.-H., & Hu, F. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.11.030 · Cited by 131

Novel amphiphilic chitosan derivatives: Synthesis, characterization and micellar solubilization of rotenone

Lao, S., Zhang, Z., Xu, H., & Jiang, G. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.06.044 · Cited by 127

Preparation and characterization of N-succinyl-N′-octyl chitosan micelles as doxorubicin carriers for effective anti-tumor activity

Xiang-yang, X., Li, L., Jianping, Z., Shiyue, L., Jie, Y., Xiaojin, Y., & Jinsheng, R. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.12.006 · Cited by 123

Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes

Thibault, M., Nimesh, S., Lavertu, M., & Buschmann, M. D. (2010) · Molecular Therapy · doi:10.1038/mt.2010.143 · Cited by 122

Disulfide-crosslinked chitosan hydrogel for cell viability and controlled protein release

Wu, Z., Zhang, X. G., Zheng, C., Li, C. X., Zhang, S. M., Dong, R. N., & Yu, D. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.01.010 · Cited by 118

Kinetics of hydrolysis of chitin/chitosan oligomers in concentrated hydrochloric acid

Einbu, A., Grasdalen, H., & Vårum, K. M. (2007) · Carbohydrate Research · doi:10.1016/j.carres.2007.02.022 · Cited by 113

Effect of PEGylation on the Toxicity and Permeability Enhancement of Chitosan

Casettari, L., Vllasaliu, D., Mantovani, G., Howdle, S. M., Stolnik, S., & Illum, L. (2010) · Biomacromolecules · doi:10.1021/bm100522c · Cited by 112

Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive Chitosan hydrogel

Wang, H., Zhang, X., Li, Y., Ma, Y.-T., Zhang, Y., Liu, Z., Zhou, J., Lin, Q., Wang, Y., Duan, C., et al. (2010) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.03.016 · Cited by 111

The promise of chitosan microspheres in drug delivery systems

Varshosaz, J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.3.263 · Cited by 111

An in situ formed biodegradable hydrogel for reconstruction of the corneal endothelium

Liang, Y., Liu, W., Han, B., Yang, C., Ma, Q., Song, F., & Bi, Q. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.07.043 · Cited by 110

Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives

Zhang, C., Ding, Y., Yu, Q., & Ping, Q. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.031 · Cited by 109

Preparation of polymeric micelles based on chitosan bearing a small amount of highly hydrophobic groups

Jiang, G., Quan, D., Liao, K., et al. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.04.008 · Cited by 108

Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells

Jere, D., Jiang, H., Kim, Y.-K., Arote, R. B., Choi, Y., Yun, C., Cho, M., & Cho, C. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.05.046 · Cited by 107

Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA

Noh, S. M., Park, M. O., Shim, G., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.005 · Cited by 106

PEGylated chitosan-based polymer micelle as an intracellular delivery carrier for anti-tumor targeting therapy

Hu, F., Meng, P., Dai, Y.-Q., Du, Y., You, J., Wei, X.-H., & Yuan, H. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.06.015 · Cited by 104

Mannosylated chitosan-graft-polyethylenimine as a gene carrier for Raw 264.7 cell targeting

Jiang, H., Kim, Y.-K., Arote, R. B., Jere, D., Quan, J., Yu, J., Choi, Y., Nah, J., Cho, M., & Cho, C. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.03.033 · Cited by 103

PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: In vitro characterization and in vivo evaluation

Qu, G., Yao, Z., Zhang, C., Wu, X., & Ping, Q. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.01.004 · Cited by 103

Morphology and gelation of thermosensitive chitosan hydrogels

Crompton, K. E., Prankerd, R. J., Paganin, D. M., Scott, T. F., Horne, M. K., Finkelstein, D. I., Gross, K.-A., & Forsythe, J. S. (2005) · Biophysical Chemistry · doi:10.1016/j.bpc.2005.03.009 · Cited by 101

Potential of an injectable chitosan/starch/β-glycerol phosphate hydrogel for sustaining normal chondrocyte function

Ngoenkam, J., Faikrua, A., Yasothornsrikul, S., & Viyoch, J. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.02.028 · Cited by 101

Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution

Saravanakumar, G., Min, K. H., Min, D. S., Kim, A. Y., Lee, C.-M., Cho, Y. W., Lee, S. C., Kim, K., Jeong, S. Y., Park, K., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.06.015 · Cited by 100

A series of novel chitosan derivatives: Synthesis, characterization and micellar solubilization of paclitaxel

Yao, Z., Zhang, C., Ping, Q., & Yu, L. L. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.08.023 · Cited by 99

Core-modified chitosan-based polymeric micelles for controlled release of doxorubicin

Ye, Y.-Q., Yang, F.-L., Hu, F., Du, Y., Yuan, H., & He-yong, Y. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.10.035 · Cited by 99

Thiolated Chitosans: Design and In Vivo Evaluation of a Mucoadhesive Buccal Peptide Drug Delivery System

Langoth, N., Kahlbacher, H., Schöffmann, G., Schmerold, I., Schuh, M., Franz, S., Kurka, P., & Bernkop‐Schnürch, A. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-9533-5 · Cited by 98

A new atherosclerotic lesion probe based on hydrophobically modified chitosan nanoparticles functionalized by the atherosclerotic plaque targeted peptides

Park, K., Hong, H.-Y., Moon, H. J., Lee, B.-H., Kim, I., Kwon, I. C., & Rhee, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.03.019 · Cited by 97

Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair

Zuidema, J. M., Pap, M. M., Jaroch, D., Morrison, F. A., & Gilbert, R. J. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.11.039 · Cited by 94

A thermosensitive chitosan/poly(vinyl alcohol) hydrogel containing hydroxyapatite for protein delivery

Tang, Y., Du, Y., Li, Y., Wang, X., & Hu, X. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32240 · Cited by 94

Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin

Duan, K., Zhang, X., Tang, X., Yu, J., Liu, S., Wang, D., Li, Y., & Huang, J. T. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.12.007 · Cited by 91

Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)

Kotzé, A. F., Thanou, M. M., Lueßen, H. L., de Boer, (. G., Verhoef, J. C., & Junginger, H. E. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00006-5 · Cited by 90

Self-aggregated nanoparticles of cholesterol-modified glycol chitosan conjugate: Preparation, characterization, and preliminary assessment as a new drug delivery carrier

Yu, J., Li, Y., Qiu, L., & Jin, Y. (2008) · European Polymer Journal · doi:10.1016/j.eurpolymj.2008.01.013 · Cited by 90

Specific Interactions in Modified Chitosan Systems

Rinaudo, M., Auzély‐Velty, R., Vallin, C., & Муллагалиев, И. Р. (2005) · Biomacromolecules · doi:10.1021/bm0580025 · Cited by 84

Transfection of primary chondrocytes using chitosan-pEGFP nanoparticles

Zhao, X., Yu, S., Feng-lan, W., Mao, Z.-B., & Yu, C. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.01.016 · Cited by 84

Nanocarriers

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Preparation, fabrication and biocompatibility of novel injectable temperature-sensitive chitosan/glycerophosphate/collagen hydrogels

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