Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

Bernard, L.; Leroux, C.; Chilliard, Y.

doi:10.1007/978-0-387-74087-4_2

Cited by 249Ruminant Nutrition and Digestive PhysiologyMilk Quality and Mastitis in Dairy CowsLipid metabolism and biosynthesis

Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

Bernard, L., Leroux, C., Chilliard, Y.·2007·Advances in Experimental Medicine and Biology

DOI 10.1007/978-0-387-74087-4_2

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Abstract

The effect of nutrition on milk fat yield and composition has largely been investigated in cows and goats, with some differences for fatty acid (FA) composition responses and marked species differences in milk fat yield response. Recently, the characterization of lipogenic genes in ruminant species allowed in vivo studies focused on the effect of nutrition on mammary expression of these genes, in cows (mainly fed milk fat-depressing diets) and goats (fed lipid-supplemented diets). These few studies demonstrated some similarities in the regulation of gene expression between the two species, although the responses were not always in agreement with milk FA secretion responses. A central role for trans-10 C18:1 and trans-10, cis-12 CLA as regulators of milk fat synthesis has been proposed. However, trans-10 C18:1 does not directly control milk fat synthesis in cows, despite the fact that it largely responds to dietary factors, with its concentration being negatively correlated with milk fat yield response in cows and, to a lesser extent, in goats. Milk trans-10, cis-12 CLA is often correlated with milk fat depression in cows but not in goats and, when postruminally infused, acts as an inhibitor of the expression of key lipogenic genes in cows. Recent evidence has also proven the inhibitory effect of the trans-9, cis-11 CLA isomer. The molecular mechanisms by which nutrients regulate lipogenic gene expression have yet to be well identified, but a central role for SREBP-1 has been outlined as mediator of FA effects, whereas the roles of PPARs and STAT5 need to be determined. It is expected that the development of in vitro functional systems for lipid synthesis and secretion will allow future progress toward (1) the identification of the inhibitors and activators of fat synthesis, (2) the knowledge of cellular mechanisms, and (3) the understanding of differences between ruminant species.

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Medium-chain fatty acids (lauric and myristic acids) have a positive correlation with enteric CH4 production because they are synthesized de novo in the mammary gland from ruminal acetate and butyrate.
“The medium-chain FA (lauric and myristic acids) have shown a positive correlation with enteric CH4 production as these FA are synthesized (de novo synthesis) in the mammary gland from ruminal acetate and butyrate (213).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [213]

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Diets supplemented with starch and corn oil, marine algae, or hydrogenated palm oil differentially modulate milk fat secretion and composition in cows and goats: A comparative study
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Conjugated linoleic acid-induced milk fat depression in lactating ewes is accompanied by reduced expression of mammary genes involved in lipid synthesis
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The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls
Bartoň, L., Kott, T., Bureš, D., Řehák, D., Zahrádková, R., & Kottová, B. (2009) · Meat Science · doi:10.1016/j.meatsci.2009.11.016 · Cited by 67 · see citing works
Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells
Li, X., Li, P., Wang, L., Zhang, M., & Gao, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02160 · Cited by 67 · see citing works
Effect of sunflower-seed oil or linseed oil on milk fatty acid secretion and lipogenic gene expression in goats fed hay-based diets
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Weighted gene co-expression network analysis identifies modules and functionally enriched pathways in the lactation process
Farhadian, M., Rafat, S. A., Panahi, B., & Mayack, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-81888-z · Cited by 63 · see citing works
The Effect of Seasonal Thermal Stress on Lipid Mobilisation, Antioxidant Status and Reproductive Performance in Dairy Cows
Turk, R., Podpečan, O., Mrkun, J., Flegar-Meštrić, Z., Perkov, S., & Zrimšek, P. (2015) · Reproduction in Domestic Animals · doi:10.1111/rda.12534 · Cited by 63 · see citing works
The mammary gland in domestic ruminants: A systems biology perspective
Ferreira, A. M., Bislev, S. L., Bendixen, E., & de Almeida, A. M. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.09.012 · Cited by 58 · see citing works
Effects of Glucose Availability on Expression of the Key Genes Involved in Synthesis of Milk Fat, Lactose and Glucose Metabolism in Bovine Mammary Epithelial Cells
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Effects of short- and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells
Jacobs, A. A. A., Dijkstra, J., Liesman, J. S., VandeHaar, M. J., Lock, A. L., van Vuuren, A. M., Hendriks, W. H., & van Baal, J. (2013) · animal · doi:10.1017/s175173111300061x · Cited by 57 · see citing works
Influence of Body Condition on Serum Metabolic Indicators of Lipid Mobilization and Oxidative Stress in Dairy Cows During the Transition Period
Folnožić, I., Turk, R., Đuričić, D., Vince, S., Pleadin, J., Flegar-Meštrić, Z., Valpotić, H., Dobranić, T., Gračner, D., & Samardžija, M. (2015) · Reproduction in Domestic Animals · doi:10.1111/rda.12608 · Cited by 56 · see citing works
Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions
Duchemin, S., Bovenhuis, H., Stoop, W. M., Bouwman, A. C., van Arendonk, J. A. M., & Visker, M. H. P. W. (2012) · Journal of Dairy Science · doi:10.3168/jds.2012-5454 · Cited by 56 · see citing works
Expression and Nutritional Regulation of Stearoyl-CoA Desaturase Genes in the Ruminant Mammary Gland: Relationship with Milk Fatty Acid Composition
Bernard, L., Leroux, C., & Chilliard, Y. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7969-7_13 · Cited by 54 · see citing works
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Dietary n‐3 Fatty Acids Significantly Suppress Lipogenesis in Bovine Muscle and Adipose Tissue: A Functional Genomics Approach
Hiller, B., Herdmann, A., & Nuernberg, K. (2011) · Lipids · doi:10.1007/s11745-011-3571-z · Cited by 53 · see citing works
Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period
Turk, R., Podpečan, O., Mrkun, J., Kosec, M., Flegar-Meštrić, Z., Perkov, S., Starič, J., Robić, M., Belić, M. R., & Zrimšek, P. (2013) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2013.07.014 · Cited by 52 · see citing works
Linseed oil and DGAT1 K232A polymorphism: Effects on methane emission, energy and nitrogen metabolism, lactation performance, ruminal fermentation, and rumen microbial composition of Holstein-Friesian cows
van Gastelen, S., Visker, M. H. P. W., Edwards, J. E., Fernandes, E. C. A., Hettinga, K. A., Alferink, S. J. J., Hendriks, W. H., Bovenhuis, H., Smidt, H., & Dijkstra, J. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12367 · Cited by 51 · see citing works
Effects of branched-chain volatile fatty acids on lactation performance and mRNA expression of genes related to fatty acid synthesis in mammary gland of dairy cows
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Adipose Tissue Modification through Feeding Strategies and Their Implication on Adipogenesis and Adipose Tissue Metabolism in Ruminants
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Effect of calcium salts of a mixture of conjugated linoleic acids containingtrans-10,cis-12 in the diet on milk fat synthesis in goats
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Fish oil-induced milk fat depression and associated downregulation of mammary lipogenic genes in dairy ewes
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Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells
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Prepartum fatty acid supplementation in sheep. II. Supplementation of eicosapentaenoic acid and docosahexaenoic acid during late gestation alters the fatty acid profile of plasma, colostrum, milk and adipose tissue, and increases lipogenic gene expression of adipose tissue1
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Characterisation and nutritional regulation of the main lipogenic genes in the ruminant lactating mammary gland
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Authors: Bernard, L., Leroux, C., & Chilliard, Y.
Affiliations: Unité Mixte de Recherche sur les Herbivores (FR)
Corresponding author: Bernard, L.
ORCID: Bernard, L.
Leroux, C.
Chilliard, Y.
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer New York
Published: 2007-12-25
Volume: 606
Pages: 67-108
DOI: 10.1007/978-0-387-74087-4_2
OpenAlex: W2124307313
Cited by: 249
References: 190
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 16 · 2020: 14 · 2019: 11 · 2018: 12 · 2017: 21 · 2016: 18 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 15
FWCI: 34.30
Type: book chapter
Language: en
Open access: closed
Locations: Springer eBooks (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Milk Quality and Mastitis in Dairy Cows
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: lipogenic gene expression, mammary gland, milk fat synthesis, ruminant nutrition, trans-10, cis-12 CLA, SREBP1, peroxisome proliferator-activated receptors, STAT5, milk fat depression, cattle, goats, fatty acid composition, species differences
MeSH terms: Animals, Animal Nutritional Physiological Phenomena, Gene Expression Regulation, Lactation, Mammary Glands, Animal, Ruminants, Lipogenesis

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Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

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