Cited by 104Cannabis and Cannabinoid ResearchEicosanoids and Hypertension PharmacologyFatty Acid Research and Health

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Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System

Fezza, Filomena, De Simone, Chiara, Amadio, Daniele, Maccarrone, Mauro·2008·Subcellular Biochemistry

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Abstract

The family of endocannabinoids contains several polyunsaturated fatty acid amides such as anandamide (AEA), but also esters such as 2-arachidonoylglycerol (2-AG). These compounds are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta9-tetrahydrocannabinol (Delta9-THC), the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA at its receptors is limited by cellular uptake, through a putative membrane transporter, followed by intracellular degradation by fatty acid amide hydrolase (FAAH). Growing evidence demonstrates that FAAH is the critical regulator of the endogenous levels of AEA, suggesting that it may serve as an attractive therapeutic target for the treatment of human disorders. In particular, FAAH inhibitors may be next generation therapeutics of potential value for the treatment of pathologies of the central nervous system, and of peripheral tissues. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors, are the topic of this chapter.

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Authors: Fezza, F., De Simone, C., Amadio, D., & Maccarrone, M.
Affiliations: University of Rome Tor Vergata (IT)
ORCID: Fezza, Filomena
Maccarrone, Mauro
Venue: Subcellular Biochemistry
Publisher: Springer Netherlands
Published: 2008
Volume: 49
Pages: 101-132
ISSN: 0306-0225 (ISSN-L)
DOI: 10.1007/978-1-4020-8831-5_4
OpenAlex: W97923480
Cited by: 99
References: 156
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 44.84
Type: book chapter
Language: en
Open access: closed
Locations: Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: fatty acid amide hydrolase, endocannabinoid system, anandamide, 2-arachidonoylglycerol, FAAH inhibitors, cannabinoid receptors, delta-9-tetrahydrocannabinol, membrane transporters, intracellular degradation, therapeutic target, central nervous system disorders
MeSH terms: Fatty Acid Amide Hydrolases, Amidohydrolases, Animals, Gene Expression Regulation, Humans, Models, Molecular, Receptors, Cannabinoid, Cannabinoid Receptor Modulators, Endocannabinoids

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks