Autophagy in the Retina: A Potential Role in Age-Related Macular Degeneration

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536 · see citing works

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,422 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

Lysosomes: fusion and function

Luzio, J. P., Pryor, P. R., & Bright, N. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2217 · Cited by 1,737 · see citing works

Autophagy: molecular machinery for self-eating

Yorimitsu, T., & Klionsky, D. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401765 · Cited by 1,540 · see citing works

A Role for Ubiquitin in Selective Autophagy

Kirkin, V., McEwan, D. G., Novak, I., & Đikić, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.026 · Cited by 1,227 · see citing works

Studies on the mechanisms of autophagy: formation of the autophagic vacuole.

Dunn, W. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.1923 · Cited by 787 · see citing works

The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

Geng, J., & Klionsky, D. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.163 · Cited by 781 · see citing works

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P., Backer, J., Natt, F., Bos, J. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506925102 · Cited by 753 · see citing works

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

Korolchuk, V. I., Mansilla, A., Menzies, F. M., & Rubinsztein, D. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.021 · Cited by 657 · see citing works

Oxidative Stress and Autophagy

Kiffin, R., Bandyopadhyay, U., & Cuervo, A. M. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.152 · Cited by 527 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

Punzo, C., Kornacker, K., & Cepko, C. L. (2008) · Nature Neuroscience · doi:10.1038/nn.2234 · Cited by 515 · see citing works

A block of autophagy in lysosomal storage disorders

Settembre, C., Fraldi, A., Jahreiss, L., Spampanato, C., Venturi, C. B., Medina, D. L., de Pablo, R., Tacchetti, C., Rubinsztein, D. C., & Ballabio, A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm289 · Cited by 500 · see citing works

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration

Wang, A. L., Lukas, T. J., Yuan, M., Du, N. Y., Tso, M. O. M., & Neufeld, A. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004160 · Cited by 357 · see citing works

'Protein Modifications: Beyond the Usual Suspects' Review Series

Ikeda, F., & Đikić, I. (2008) · Cited by 316 · see citing works

Mechanisms of acute axonal degeneration in the optic nerve in vivo

Knöferle, J., Koch, J. C., Ostendorf, T., Michel, U., Planchamp, V., Vutova, P., Tönges, L., Stadelmann, C., Brück, W., Bähr, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909794107 · Cited by 310 · see citing works

Necroptosis, a novel form of caspase‐independent cell death, contributes to neuronal damage in a retinal ischemia‐reperfusion injury model

Rosenbaum, D. M., Degterev, A., David, J., Rosenbaum, P. S., Roth, S., Grotta, J. C., Cuny, G. D., Yuan, J., & Savitz, S. I. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22314 · Cited by 248 · see citing works

Inhibition of the ATP‐driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2‐E may contribute to the pathogenesis of age‐related macular degeneration

Bergmann, M., Schütt, F., Holz, F. G., & Kopitz, J. (2004) · The FASEB Journal · doi:10.1096/fj.03-0289fje · Cited by 226 · see citing works

Autophagosome-Lysosome Fusion Depends on the pH in Acidic Compartments in CHO Cells

Kawai, A., Uchiyama, H., Takano, S., Nakamura, N., & Ohkuma, S. (2007) · Autophagy · doi:10.4161/auto.3634 · Cited by 205 · see citing works

Autophagy for tissue homeostasis and neuroprotection

Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195 · see citing works

Apoptosis and Autophagy in Photoreceptors Exposed to Oxidative Stress

Kunchithapautham, K., & Rohrer, B. (2007) · Autophagy · doi:10.4161/auto.4294 · Cited by 171 · see citing works

Sequestosome 1/p62 – More than just a scaffold

Seibenhener, M. L., Geetha, T., & Wooten, M. W. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.12.027 · Cited by 165 · see citing works

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

Krohne, T. U., Stratmann, N. K., Kopitz, J., & Holz, F. G. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.12.011 · Cited by 154 · see citing works

The formation of autofluorescent granules in cultured human RPE.

Boulton, M. E., McKechnie, N. M., Breda, J., Bayly, M., & Marshall, J. (1989) · PubMed · Cited by 143 · see citing works

Restoration of Lysosomal pH in RPE Cells from Cultured Human and ABCA4 ^−/− Mice: Pharmacologic Approaches and Functional Recovery

Liu, J., Lu, W., Reigada, D., Nguyen, J., Laties, A. M., & Mitchell, C. H. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0675 · Cited by 141 · see citing works

TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease

Wang, T., Lao, U., & Edgar, B. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904090 · Cited by 135 · see citing works

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy‐mediated proteolysis in human retinal pigment epithelial cells

Ryhänen, T., Hyttinen, J. M. T., Kopitz, J., Rilla, K., Kuusisto, E., Mannermaa, E., Viiri, J., Holmberg, C. I., Immonen, I., Meri, S., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00577.x · Cited by 131 · see citing works

Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)

Kaarniranta, K., Salminen, A., Eskelinen, E., & Kopitz, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.01.001 · Cited by 122 · see citing works

The Importance of Mitochondria in Age-Related and Inherited Eye Disorders

Jarrett, S. G., Lewin, A. S., & Boulton, M. E. (2010) · Ophthalmic Research · doi:10.1159/000316480 · Cited by 98 · see citing works

The effects of hibernation on cone visual cells in the ground squirrel.

Remé, C. E., & Young, R. W. (1977) · PubMed · Cited by 93 · see citing works

Activation of autophagy in retinal ganglion cells

Kim, S., Munemasa, Y., Kwong, J. M. K., Ahn, J. H., Mareninov, S., Gordon, L. K., Caprioli, J., & Piri, N. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21738 · Cited by 83 · see citing works

Where do they come from? Insights into autophagosome formation

Hamasaki, M., & Yoshimori, T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.061 · Cited by 77 · see citing works

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.

Viiri, J., Hyttinen, J. M. T., Ryhänen, T., Rilla, K. J., Paimela, T., Kuusisto, E., Siitonen, A., Urtti, A. O., Salminen, A., & Kaarniranta, K. (2010) · PubMed Central · Cited by 67 · see citing works

ARPE-19 retinal pigment epitheliaL CELLS are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron

Kurz, T., Karlsson, M., Brunk, U. T., & NILSSON, S. E. G. (2009) · Autophagy · doi:10.4161/auto.5.4.7961 · Cited by 65 · see citing works

Using LC3 to monitor autophagy flux in the retinal pigment epithelium

Wang, A. L., Boulton, M. E., Dunn, W. A., Rao, H. V., Cai, J., Lukas, T. J., & Neufeld, A. H. (2009) · Autophagy · doi:10.4161/auto.5.8.10087 · Cited by 62 · see citing works

Lipofuscin granules in human photoreceptor cells.

Iwasaki, M., & Inomata, H. (1988) · PubMed · Cited by 59 · see citing works

Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium.

Burke, J. M., & Skumatz, C. M. B. (1998) · PubMed · Cited by 41 · see citing works

Autophagy – hot topic in AMD

Kaarniranta, K. (2010) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2009.01840.x · Cited by 29 · see citing works

Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?

Lieberthal, W. (2008) · Kidney International · doi:10.1038/ki.2008.325 · Cited by 24 · see citing works

The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina.

Wu, B. X., Darden, A. G., Laser, M., Li, Y., Ce, C., Hazard, E. S., & Jx, M. (2006) · PubMed · Cited by 22 · see citing works

[Circadian rhythm, the retina and light].

Remé, C. E., & Wirz‐Justice, A. (1985) · PubMed · Cited by 4 · see citing works

Zirkadiane Rhythmen, Netzhaut und Licht*

Remé, C. E., & Wirz‐Justice, A. (1985) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/s-2008-1050899 · Cited by 3 · see citing works

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works

Mechanisms of Age-Related Macular Degeneration

Ambati, J., & Fowler, B. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.018 · Cited by 1,029 · see citing works

Consequences of oxidative stress in age-related macular degeneration

Jarrett, S. G., & Boulton, M. E. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.009 · Cited by 537 · see citing works

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Mitter, S. K., Song, C., Qi, X., Mao, H., Rao, H., Akin, D., Lewin, A., Grant, M., Dunn, W., Ding, J., et al. (2014) · Autophagy · doi:10.4161/auto.36184 · Cited by 449 · see citing works

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

Golestaneh, N., Chu, Y., Xiao, Y.-Y., Stoleru, G. L., & Theos, A. C. (2017) · Cell Death & Disease · doi:10.1038/cddis.2016.453 · Cited by 357 · see citing works

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Kaarniranta, K., Sinha, D., Blasiak, J., Kauppinen, A., Veréb, Z., Salminen, A., Boulton, M. E., & Petrovski, G. (2013) · Autophagy · doi:10.4161/auto.24546 · Cited by 326 · see citing works

Age‐Related Macular Degeneration: New Paradigms for Treatment and Management of AMD

Hernández-Zimbrón, L. F., Zamora-Alvarado, R., la Paz, L. D. O.-D., Vélez-Montoya, R., Zenteno, E., Gulías-Cañizo, R., Quiroz–Mercado, H., & González-Salinas, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8374647 · Cited by 239 · see citing works

Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms

Somasundaran, S., Constable, I. J., Mellough, C., & Carvalho, L. S. (2020) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.13834 · Cited by 195 · see citing works

Senescence in the pathogenesis of age-related macular degeneration

Blasiak, J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03420-x · Cited by 183 · see citing works

Age-related macular degeneration: A two-level model hypothesis

Rozing, M. P., Durhuus, J. A., Nielsen, M. K., Subhi, Y., Kirkwood, T. B. L., Westendorp, R. G., & Sørensen, T. L. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100825 · Cited by 183 · see citing works

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

Hyttinen, J. M. T., Amadio, M., Viiri, J., Pascale, A., Salminen, A., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.002 · Cited by 165 · see citing works

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

Kaarniranta, K., Tokarz, P., Koskela, A. K. J., Paterno, J. J., & Błasiak, J. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9371-8 · Cited by 171 · see citing works

The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration

Tisi, A., Feligioni, M., Passacantando, M., Ciancaglini, M., & Maccarone, R. (2021) · Cells · doi:10.3390/cells10010064 · Cited by 144 · see citing works

The cell stress machinery and retinal degeneration

Athanasiou, D., Aguilà, M., Bevilacqua, D., Novoselov, S. S., Parfitt, D. A., & Cheetham, M. E. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.020 · Cited by 143 · see citing works

Autophagy in the eye: implications for ocular cell health.

Frost, L. S., Mitchell, C. H., & Boesze-Battaglia, K. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.04.010 · Cited by 134 · see citing works

Deletion of autophagy inducer <i>RB1CC1</i> results in degeneration of the retinal pigment epithelium

Yao, J., Jia, L., Khan, N., Lin, C., Mitter, S. K., Boulton, M. E., Dunaief, J. L., Klionsky, D. J., Guan, J.-L., Thompson, D. A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1041699 · Cited by 130 · see citing works

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

Akhtar‐Schäfer, I., Wang, L., Krohne, T. U., Xu, H., & Langmann, T. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708259 · Cited by 127 · see citing works

Age-related macular degeneration and the role of the complement system

McHarg, S., Clark, S. J., Day, A. J., & Bishop, P. N. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.02.032 · Cited by 126 · see citing works

Role of Oxidative Stress in Ocular Diseases: A Balancing Act

Shu, D. Y., Chaudhary, S., Cho, K., Lennikov, A., Miller, W. P., Thorn, D. C., Yang, M., & McKay, T. B. (2023) · Metabolites · doi:10.3390/metabo13020187 · Cited by 118 · see citing works

Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy

Wang, W., Wang, Q., Wan, D., Sun, Y., Wang, L., Chen, H., Liu, C., Petersen, R. B., Li, J., Xue, W., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1293768 · Cited by 111 · see citing works

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

Song, C., Mitter, S. K., Qi, X., Beli, E., Rao, H. V., Ding, J., Ip, C. S., Gu, H., Akin, D., Dunn, W. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171940 · Cited by 100 · see citing works

Protective Effect of Melatonin against Oxidative Stress‐Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

Chang, C.-C., Huang, T.-Y., Chen, Y.-H., Huang, T., Lin, L.-C., Chang, Y.-J., & Hsia, S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9015765 · Cited by 100 · see citing works

Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration

Zhang, J., Bai, Y., Huang, L. J., Qi, Y., Zhang, Q., Li, S., Wu, Y., & Li, X. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.330 · Cited by 99 · see citing works

Fatty acid oxidation and photoreceptor metabolic needs

Fu, Z., Kern, T. S., Hellström, A., & Smith, L. E. H. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000618 · Cited by 98 · see citing works

Relationship between Oxidative Stress, Circadian Rhythms, and AMD

Fanjul‐Moles, M. L., & López-Riquelme, G. O. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7420637 · Cited by 95 · see citing works

Dyslipidemia in retinal metabolic disorders

Fu, Z., Chen, C. T., Cagnone, G., Heckel, É., Sun, Y., Cakir, B., Tomita, Y., Huang, S., Li, Q., Britton, W. R., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910473 · Cited by 92 · see citing works

Studying melanin and lipofuscin in RPE cell culture models

Boulton, M. E. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.01.016 · Cited by 92 · see citing works

Involvement of Nrf2 in Ocular Diseases

Batliwala, S. Y., Xavier, C., Liu, Y., Wu, H., & Pang, I.-H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1703810 · Cited by 89 · see citing works

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

Liu, J., Copland, D. A., Theodoropoulou, S., Chiu, H. A. A., Barba, M. D., Mak, K. W., Mack, M., Nicholson, L. B., & Dick, A. D. (2016) · Scientific Reports · doi:10.1038/srep20639 · Cited by 87 · see citing works

Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations

Guha, S., Coffey, E. E., Lu, W., Lim, J. C.-S., Beckel, J. M., Laties, A. M., Boesze‐Battaglia, K., & Mitchell, C. H. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.013 · Cited by 81 · see citing works

Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization

Klettner, A., Kauppinen, A., Błasiak, J., Roider, J., Salminen, A., & Kaarniranta, K. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.013 · Cited by 80 · see citing works

Systems pharmacology identifies drug targets for Stargardt disease–associated retinal degeneration

Chen, Y., Palczewska, G., Mustafi, D., Golczak, M., Dong, Z., Sawada, O., Maeda, T., Maeda, A., & Palczewski, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69076 · Cited by 79 · see citing works

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Hyttinen, J. M. T., Viiri, J., Kaarniranta, K., & Błasiak, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2843-7 · Cited by 78 · see citing works

Targeting MAPK Signaling in Age-Related Macular Degeneration

Kyosseva, S. V. (2016) · Ophthalmology and Eye Diseases · doi:10.4137/oed.s32200 · Cited by 74 · see citing works

Improving retinal mitochondrial function as a treatment for age-related macular degeneration

Ebeling, M. C., Polanco, J. R., Qu, J., Tu, C., Montezuma, S. R., & Ferrington, D. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101552 · Cited by 74 · see citing works

Exogenous NAD+ decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy

Zhu, Y. J., Zhao, K., Tong, Y., Zhou, Y., Wang, Y.-X., Zhao, P., & Wang, Z. (2016) · Scientific Reports · doi:10.1038/srep26322 · Cited by 68 · see citing works

MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges

Moustardas, P., Aberdam, D., & Lagali, N. (2023) · Cells · doi:10.3390/cells12040617 · Cited by 63 · see citing works

Autophagy in the retinal pigment epithelium: a new vision and future challenges

Intartaglia, D., Giamundo, G., & Conte, I. (2021) · FEBS Journal · doi:10.1111/febs.16018 · Cited by 62 · see citing works

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.

Zhang, Y., Cross, S. D., Stanton, J. B., Marmorstein, A. D., Le, Y. Z., & Marmorstein, L. Y. (2017) · Europe PMC (PubMed Central) · Cited by 60 · see citing works

Roles for the ubiquitin–proteasome pathway in protein quality control and signaling in the retina: Implications in the pathogenesis of age-related macular degeneration

Shang, F., & Taylor, A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.001 · Cited by 60 · see citing works

Autophagy: A Role in the Apoptosis, Survival, Inflammation, and Development of the Retina

Lin, W., & Xu, G. (2018) · Ophthalmic Research · doi:10.1159/000487486 · Cited by 57 · see citing works

Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

Kim, J., Lee, Y. J., & Won, J. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212298 · Cited by 57 · see citing works

Epigallocatechin-gallate (EGCG) regulates autophagy in human retinal pigment epithelial cells: A potential role for reducing UVB light-induced retinal damage

Li, C., Yao, J., Tao, Z.-F., Li, X., Jiang, Q. L., & Yan, B. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.097 · Cited by 53 · see citing works

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

Sethna, S., Scott, P. A., Giese, A. P. J., Duncan, T. E., Jian, X., Riazuddin, S. A., Randazzo, P. A., Redmond, T. M., Bernstein, S. L., Riazuddin, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24056-1 · Cited by 47 · see citing works

Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage

Yan, F., Wang, H., Gao, Y., Xu, J., & Zheng, W. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00021 · Cited by 47 · see citing works

The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy

Cammalleri, M., Locri, F., Catalani, E., Filippi, L., Cervia, D., Monte, M. D., & Bagnoli, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00395 · Cited by 46 · see citing works

Metformin, A Potential Role in Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Romdhoniyyah, D. F., Harding, S. P., Cheyne, C. P., & Beare, N. A. V. (2021) · Ophthalmology and Therapy · doi:10.1007/s40123-021-00344-3 · Cited by 48 · see citing works

Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium

Dhingra, A., Bell, B. A., Peachey, N. S., Daniele, L. L., Reyes-Reveles, J., Sharp, R. C., Jun, B., Bazan, N. G., Sparrow, J. R., Kim, H. J., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00351 · Cited by 41 · see citing works

Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell

Lei, L., Tzekov, R. T., Li, H., McDowell, J. H., Gao, G., Smith, W. C., Tang, S., & Kaushal, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040728 · Cited by 41 · see citing works

Autophagy and Age-Related Eye Diseases

Yang, X., Pan, X., Zhao, X., Jin, L., Xu, M., Bai, D., Hu, Y., Liu, X., Yu, Q., & Gao, D. (2019) · BioMed Research International · doi:10.1155/2019/5763658 · Cited by 40 · see citing works

Doyne lecture 2016: intraocular health and the many faces of inflammation

Dick, A. D. (2016) · Eye · doi:10.1038/eye.2016.177 · Cited by 38 · see citing works

Nanoceria Particles Are an Eligible Candidate to Prevent Age-Related Macular Degeneration by Inhibiting Retinal Pigment Epithelium Cell Death and Autophagy Alterations

Tisi, A., Flati, V., Monache, S. D., Lozzi, L., Passacantando, M., & Maccarone, R. (2020) · Cells · doi:10.3390/cells9071617 · Cited by 37 · see citing works

Inflammatory Cytokines Protect Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Death

Juel, H. B., Faber, C., Svendsen, S. G., Vallejo, A. N., & Nissen, M. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064619 · Cited by 34 · see citing works

Autophagy and ER-stress contribute to photoreceptor degeneration in cultured adult porcine retina

Mohlin, C., Taylor, L., Ghosh, F. K., & Johansson, K. U. I. (2014) · Brain Research · doi:10.1016/j.brainres.2014.08.055 · Cited by 33 · see citing works

17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy

Wei, Q., Liang, X., Ye, P., Yu, D., Zhang, R., Jin, H., Fan, J., Cai, W., Ren, C., & Yu, J. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s176349 · Cited by 32 · see citing works

Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond

Markitantova, Y. V., & Simirskii, V. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031193 · Cited by 32 · see citing works

7-Ketocholesterol disturbs RPE cells phagocytosis of the outer segment of photoreceptor and induces inflammation through ERK signaling pathway

Yang, C., Xie, L., Gu, Q., Qiu, Q., Wu, X., & Yin, L. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107849 · Cited by 31 · see citing works

Glucosamine-Induced Autophagy through AMPK–mTOR Pathway Attenuates Lipofuscin-Like Autofluorescence in Human Retinal Pigment Epithelial Cells In Vitro

Chen, C., Chen, Y., Liang, C., Tai, M., Lu, D., & Chen, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051416 · Cited by 31 · see citing works

Role of Autophagy in Hypoxia-Induced Angiogenesis of RF/6A Cells in vitro

Li, H., Du, J., & Chang, Y. (2016) · Current Eye Research · doi:10.3109/02713683.2016.1145234 · Cited by 29 · see citing works

Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells

Li, H., Du, J., Yao, G., Yao, Y., & Zhang, J. (2019) · International Journal of Ophthalmology · doi:10.18240/ijo.2019.04.05 · Cited by 29 · see citing works

Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells

Karlsson, M., Frennesson, C. I., Gustafsson, T., Brunk, U. T., NILSSON, S. E. G., & Kurz, T. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.10.014 · Cited by 29 · see citing works

Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization

Park, T. K., Lee, S. H., Choi, J., Nah, S. K., Kim, H. J., Park, H. Y., Lee, H., Lee, S. H. S., & Park, K. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.05.012 · Cited by 28 · see citing works

Role of the Ubiquitin–Proteasome in Protein Quality Control and Signaling

Shang, F., & Taylor, A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00010-9 · Cited by 28 · see citing works

Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina

Dhingra, A., Alexander, D., Reyes-Reveles, J., Sharp, R. C., & Boesze‐Battaglia, K. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-75402-4_74 · Cited by 27 · see citing works

Regulation of phagolysosomal activity by miR-204 critically influences structure and function of retinal pigment epithelium/retina

Zhang, C., Miyagishima, K. J., Dong, L., Rising, A., Nimmagadda, M., Liang, G., Sharma, R., Dejene, R., Wang, Y., Abu-Asab, M., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz171 · Cited by 26 · see citing works

Decorin Protects Retinal Pigment Epithelium Cells from Oxidative Stress and Apoptosis via AMPK‐mTOR‐Regulated Autophagy

Xie, X., Li, D., Cui, Y., Xie, T., Cai, J., & Yao, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3955748 · Cited by 26 · see citing works

Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE

Lynn, S. A., Ward, G., Keeling, E., Scott, J. A., Cree, A. J., Johnston, D. A., Page, A. M., Cuan‐Urquizo, E., Bhaskar, A., Grossel, M. C., et al. (2017) · Tissue and Cell · doi:10.1016/j.tice.2017.06.003 · Cited by 25 · see citing works

Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS

Park, C., Cha, H., Kim, M. Y., Bang, E., Moon, S., Yun, S. J., Kim, W., Noh, J. S., Kim, G., Cho, S., et al. (2022) · Antioxidants · doi:10.3390/antiox11122353 · Cited by 24 · see citing works

Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice

Xu, H., Qu, C., Gan, L., Sun, K., Tan, J., Liu, X., Jiang, Z., Tian, W., Liu, W., Zhang, S., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa062 · Cited by 24 · see citing works

MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles

Yéfimova, M., Ravel, C., Rolland, A. D., Bourmeyster, N., & Jégou, B. (2021) · Cells · doi:10.3390/cells10061443 · Cited by 24 · see citing works

Autophagy Regulating Kinases As Potential Therapeutic Targets For Age-Related Macular Degeneration

Kaarniranta, K., Kauppinen, A., Błasiak, J., & Salminen, A. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.169 · Cited by 23 · see citing works

Sodium Iodate Disrupted the Mitochondrial-Lysosomal Axis in Cultured Retinal Pigment Epithelial Cells

Lin, Y., Horng, L., Sung, H., & Wu, R.-T. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2017.0073 · Cited by 24 · see citing works

Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration

Mei, L., Yu, M., Liu, Y., Weh, E., Pawar, M. D., Li, L., Besirli, C. G., & Schwendeman, A. A. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102571 · Cited by 22 · see citing works

Preventing retinal apoptosis — Is there a common therapeutic theme?

Doonan, F., Groeger, G., & Cotter, T. G. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.003 · Cited by 22 · see citing works

Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α

Błasiak, J., Szczepańska, J., Fila, M., Pawłowska, E., & Kaarniranta, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137194 · Cited by 21 · see citing works

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Hyttinen, J. M. T., Koskela, A. K. J., Błasiak, J., & Kaarniranta, K. (2024) · Acta Ophthalmologica · doi:10.1111/aos.16744 · Cited by 20 · see citing works

Cfh Genotype Interacts With Dietary Glycemic Index to Modulate Age-Related Macular Degeneration-Like Features in Mice

Rowan, S., Weikel, K., Chang, M., Nagel, B., Thinschmidt, J. S., Carey, A. N., Grant, M. B., Fliesler, S. J., Smith, D. E., & Taylor, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12413 · Cited by 20 · see citing works

The impact of NF-κB on inflammatory and angiogenic processes in age-related macular degeneration

Almalki, W. H., & Almujri, S. S. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110111 · Cited by 19 · see citing works

Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mouse: technical and biological considerations

Rao, S. R., & Fliesler, S. J. (2021) · Autophagy · doi:10.1080/15548627.2021.1969634 · Cited by 18 · see citing works

MicroRNA-24 protects retina from degeneration in rats by down-regulating chitinase-3-like protein 1

Lian, C., Lou, H. P., Zhang, J., Tian, H., Ou, Q., Xu, J., Jin, C., Gao, F., Zhang, J., Wang, J., et al. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107791 · Cited by 18 · see citing works

Effect of Autophagy Modulators on Vascular, Glial, and Neuronal Alterations in the Oxygen-Induced Retinopathy Mouse Model

Subirada, P. V., Paz, M. C., Ridano, M. E., Lorenc, V. E., Fader, C. M., Chiabrando, G. A., & Sanchez, M. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00279 · Cited by 18 · see citing works

Antioxidative Role of Heterophagy, Autophagy, and Mitophagy in the Retina and Their Association with the Age-Related Macular Degeneration (AMD) Etiopathogenesis

Nita, M., & Grzybowski, A. E. (2023) · Antioxidants · doi:10.3390/antiox12071368 · Cited by 17 · see citing works

4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells

Varinthra, P., Huang, S., Chompoopong, S., Wen, Z., & Liu, I. Y. (2020) · Marine Drugs · doi:10.3390/md19010001 · Cited by 17 · see citing works

Role of Nuclear Factor of Activated T Cells (NFAT) Pathway in Regulating Autophagy and Inflammation in Retinal Pigment Epithelial Cells

Pan, H.-Y., Ladd, A. V., Biswal, M. R., & Valapala, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168684 · Cited by 16 · see citing works

CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1 -related AMD

Chang, Y.-J., Jenny, L. A., Li, Y.-S., Cui, X., Kong, Y., Li, Y., Sparrow, J. R., & Tsang, S. H. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215005120 · Cited by 15 · see citing works

How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration

Lakkaraju, A., Boya, P., CSETE, M. E., Ferrington, D. A., Hurley, J. B., Sadun, A. A., Shang, P., Sharma, R., Sinha, D., Ueffing, M., et al. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110219 · Cited by 14 · see citing works

Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils

Pérez-Acuña, D., Rhee, K. H., Shin, S. J., Ahn, J., Lee, J., & Lee, S. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01575-0 · Cited by 14 · see citing works

The effects of alpha lipoic acid in preventing oxidative stress-induced retinal pigment epithelial cell injury

Li, Y., Shen, H., Shi, J., & Tang, L. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0018 · Cited by 13 · see citing works

Induction of Autophagy Promotes Clearance of RHOP23H Aggregates and Protects From Retinal Degeneration

Intartaglia, D., Giamundo, G., Naso, F., Nusco, E., Giulio, S. D., Salierno, F. G., Polishchuk, E., & Conte, I. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.878958 · Cited by 13 · see citing works

Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and macular degeneration

Sant’Anna, R., Navarro, S., Ventura, S., Paraoan, L., & Foguel, D. (2016) · FEBS Letters · doi:10.1002/1873-3468.12093 · Cited by 13 · see citing works

The role of autophagy in age‐related macular degeneration

Kivinen, N. (2018) · Acta Ophthalmologica · doi:10.1111/aos.13753 · Cited by 12 · see citing works

Pomegranate protective effect on experimental ischemia/reperfusion retinal injury in rats (histological and biochemical study)

Hashem, H. E., El-Haleem, M. R. A., Amer, M. G., & Bor’i, A. (2017) · Ultrastructural Pathology · doi:10.1080/01913123.2017.1346737 · Cited by 12 · see citing works

Lipofuscin Accumulation into and Clearance from Retinal Pigment Epithelium Lysosomes: Physiopathology and Emerging Therapeutics

Nociari, M., Kiss, S., & Rodriguez-Boulan, E. J. (2017) · InTech eBooks · doi:10.5772/intechopen.69304 · Cited by 11 · see citing works

Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?

Fierz, W. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01314 · Cited by 10 · see citing works

Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue

Streeter, M. D., Rowan, S., Ray, J. D., McDonald, D. M., Volkin, J., Clark, J. P., Taylor, A., & Spiegel, D. A. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.0c00093 · Cited by 9 · see citing works

New Technologies to Study Functional Genomics of Age-Related Macular Degeneration

Nguyen, T., Urrutia-Cabrera, D., Liou, R. H.-C., Luu, C. D., Guymer, R. H., & Wong, R. C. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.604220 · Cited by 9 · see citing works

Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia

Dhingra, A., Sharp, R. C., Kim, T., Popov, A. V., Ying, G., Pietrofesa, R. A., Park, K., Christofidou‐Solomidou, M., & Boesze‐Battaglia, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115764 · Cited by 9 · see citing works

Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival

Santo, M., & Conte, I. (2021) · Cells · doi:10.3390/cells11010060 · Cited by 9 · see citing works

Role of autophagy in the eye: from physiology to disease

Morishita, H. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100592 · Cited by 8 · see citing works

Oxidized low-density lipoprotein causes ribosome reduction and inhibition of protein synthesis in retinal pigment epithelial cells

Giorgianni, F., & Beranová-Giorgianni, Š. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101345 · Cited by 8 · see citing works

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Kaarniranta, K., Sinha, D., Blasiak, J., Kauppinen, A., Veréb, Z., Salminen, A., Boulton, M. E., & Petrovski, G. (2013) · Autophagy · doi:10.4161/auto.24546 · Cited by 326 · see citing works

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells—Implications for age-related macular degeneration (AMD)

Hyttinen, J. M. T., Błasiak, J., Niittykoski, M., Kinnunen, K., Kauppinen, A., Salminen, A., & Kaarniranta, K. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.006 · Cited by 71 · see citing works

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

Golestaneh, N., Chu, Y., Xiao, Y.-Y., Stoleru, G. L., & Theos, A. C. (2017) · Cell Death &amp; Disease · doi:10.1038/cddis.2016.453 · Cited by 357 · see citing works

Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress

Zhang, Z.-Y., Bao, X.-L., Cong, Y.-Y., Fan, B., & Li, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2896036 · Cited by 80 · see citing works

Autophagy and mitophagy in age-related macular degeneration: Custodians of retinal longevity

Noorbergen, I. J., Jiménez-García, C., Jiménez‐Loygorri, J. I., & Boya, P. (2026) · Geromedicine · doi:10.70401/geromedicine.2026.0012