Cited by 185Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

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Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

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Lehman, Michael N., Hileman, Stanley M., Goodman, Robert L.·2013·Advances in Experimental Medicine and Biology

DOI 10.1007/978-1-4614-6199-9_3PMC PMC4059209

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Abstract

Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will review our current knowledge of the distribution of kisspeptin cells, fibers, and receptors in the mammalian brain, including the development, phenotype, and projections of different kisspeptin subpopulations. A fairly consistent picture emerges from this analysis. There are two major groups of kisspeptin cell bodies: a large number in the arcuate nucleus (ARC) and a smaller collection in the rostral periventricular area of the third ventricle (RP3V) of rodents and preoptic area (POA) of non-rodents. Both sets of neurons project to GnRH cell bodies, which contain Kiss1r, and the ARC kisspeptin population also projects to GnRH axons in the median eminence. ARC kisspeptin neurons contain neurokinin B and dynorphin, while a variable percentage of those cells in the RP3V of rodents contain galanin and/or dopamine. Neurokinin B and dynorphin have been postulated to contribute to the control of GnRH pulses and sex steroid negative feedback, while the role of galanin and dopamine in rostral kisspeptin neurons is not entirely clear. Kisspeptin neurons, fibers, and Kiss1r are found in other areas, including widespread areas outside the hypothalamus, but their physiological role(s) in these regions remains to be determined.

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Authors: Lehman, M. N., Hileman, S. M., & Goodman, R. L.
Affiliations: University of Mississippi Medical Center (US)
West Virginia University (US)
Corresponding author: Goodman, Robert L.
ORCID: Lehman, Michael N.
Hileman, Stanley M.
Goodman, Robert L.
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer New York
Published: 2013
Volume: 784
Pages: 27-62
ISSN: 0065-2598 (ISSN-L)
DOI: 10.1007/978-1-4614-6199-9_3
PMC: PMC4059209
OpenAlex: W206317211
Cited by: 180
References: 138
Citations by year: 2026: 5 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 16 · 2020: 16 · 2019: 19 · 2018: 14 · 2017: 10 · 2016: 19 · 2015: 10 · 2014: 9 · 2013: 8
FWCI: 75.82
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD039916, R01HD033916)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: kisspeptin neurons, kisspeptin receptor, arcuate nucleus, preoptic area, gonadotropin-releasing hormone, neurokinin B, dynorphin, galanin, dopamine, hypothalamus, comparative neuroanatomy
MeSH terms: Receptors, Kisspeptin-1, Animals, Arcuate Nucleus of Hypothalamus, Axons, Dynorphins, Humans, Gonadotropin-Releasing Hormone, Preoptic Area, Neurokinin B, Signal Transduction, Galanin, Third Ventricle, Receptors, G-Protein-Coupled, Kisspeptins

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Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

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