The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects
Open accessAbstract
Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will review our current knowledge of the distribution of kisspeptin cells, fibers, and receptors in the mammalian brain, including the development, phenotype, and projections of different kisspeptin subpopulations. A fairly consistent picture emerges from this analysis. There are two major groups of kisspeptin cell bodies: a large number in the arcuate nucleus (ARC) and a smaller collection in the rostral periventricular area of the third ventricle (RP3V) of rodents and preoptic area (POA) of non-rodents. Both sets of neurons project to GnRH cell bodies, which contain Kiss1r, and the ARC kisspeptin population also projects to GnRH axons in the median eminence. ARC kisspeptin neurons contain neurokinin B and dynorphin, while a variable percentage of those cells in the RP3V of rodents contain galanin and/or dopamine. Neurokinin B and dynorphin have been postulated to contribute to the control of GnRH pulses and sex steroid negative feedback, while the role of galanin and dopamine in rostral kisspeptin neurons is not entirely clear. Kisspeptin neurons, fibers, and Kiss1r are found in other areas, including widespread areas outside the hypothalamus, but their physiological role(s) in these regions remains to be determined.
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“In rodents and humans, pituitary LH secretion is stimulated by GnRH neurons that are prevalently activated by the neurotransmitter kisspeptin, released by two other groups of neurons, one located rostrally in the preoptic area (POA), and the other more caudally in the arcuate nucleus (ARC) [96,97].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [97]
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Metadata
- Authors
- Lehman, M. N., Hileman, S. M., & Goodman, R. L.
- Affiliations
- University of Mississippi Medical Center (US)
- West Virginia University (US)
- Corresponding author
- Goodman, Robert L.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer New York
- Published
- 2013
- Volume
- 784
- Pages
- 27-62
- ISSN
- 0065-2598 (ISSN-L)
- PMC
- PMC4059209
- OpenAlex
- W206317211
- Cited by
- 180
- References
- 138
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 16 · 2020: 16 · 2019: 19 · 2018: 14 · 2017: 10 · 2016: 19 · 2015: 10 · 2014: 9 · 2013: 8
- FWCI
- 75.82
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD039916, R01HD033916)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- kisspeptin neurons, kisspeptin receptor, arcuate nucleus, preoptic area, gonadotropin-releasing hormone, neurokinin B, dynorphin, galanin, dopamine, hypothalamus, comparative neuroanatomy
- MeSH terms
- Receptors, Kisspeptin-1, Animals, Arcuate Nucleus of Hypothalamus, Axons, Dynorphins, Humans, Gonadotropin-Releasing Hormone, Preoptic Area, Neurokinin B, Signal Transduction, Galanin, Third Ventricle, Receptors, G-Protein-Coupled, Kisspeptins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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