Transplantable Mouse Tumor Models of Breast Cancer Metastasis

A Perspective on Cancer Cell Metastasis

Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,791 · see citing works

Tumor Metastasis: Molecular Insights and Evolving Paradigms

Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011 · see citing works

Genes that mediate breast cancer metastasis to lung

Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works

A multigenic program mediating breast cancer metastasis to bone

Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,736 · see citing works

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

Guy, C. T., Cardiff, R. D., & Muller, W. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.954 · Cited by 1,523 · see citing works

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

DeRose, Y. S., Wang, G., Lin, Y.-C., Bernard, P. S., Buys, S. S., Ebbert, M., Factor, R. E., Matsen, C. B., Milash, B. A., Nelson, E. W., et al. (2011) · Nature Medicine · doi:10.1038/nm.2454 · Cited by 1,006 · see citing works

Mouse 4T1 Breast Tumor Model

Pulaski, B. A., & Ostrand‐Rosenberg, S. (2000) · Current Protocols in Immunology · doi:10.1002/0471142735.im2002s39 · Cited by 912 · see citing works

Tumor metastasis: moving new biological insights into the clinic

Wan, L., Pantel, K., & Kang, Y. (2013) · Nature Medicine · doi:10.1038/nm.3391 · Cited by 746 · see citing works

Maximizing mouse cancer models

Frese, K. K., & Tuveson, D. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2192 · Cited by 711 · see citing works

Origins of Metastatic Traits

Vanharanta, S., & Massagué, J. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.09.007 · Cited by 563 · see citing works

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

Zhang, X., Claerhout, S., Prat, A., Dobrolecki, L. E., Petrovic, I., Lai, Q., Landis, M. D., Wiechmann, L., Schiff, R., Giuliano, M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4081 · Cited by 483 · see citing works

Modeling metastasis in vivo

Khanna, C. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh261 · Cited by 466 · see citing works

Unravelling the complexity of metastasis — molecular understanding and targeted therapies

Sethi, N. S., & Kang, Y. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3125 · Cited by 396 · see citing works

The metastasis-promoting roles of tumor-associated immune cells

Smith, H. A., & Kang, Y. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1021-5 · Cited by 367 · see citing works

Immune microenvironments in solid tumors: new targets for therapyPreprint

Shiao, S. L., Ganesan, A.-P., Rugo, H. S., & Coussens, L. M. (2011) · Genes & Development · doi:10.1101/gad.169029.111 · Cited by 320 · see citing works

Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer

Li, Y., Hively, W. P., & Varmus, H. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203273 · Cited by 251 · see citing works

Technical considerations for studying cancer metastasis in vivo

Welch, D. R. (1997) · Clinical & Experimental Metastasis · doi:10.1023/a:1018477516367 · Cited by 192 · see citing works

Non-germline genetically engineered mouse models for translational cancer research

Heyer, J., Kwong, L. N., Lowe, S. W., & Chin, L. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2877 · Cited by 179 · see citing works

Analysis of Cancer Stem Cell Metastasis in Xenograft Animal Models

Kang, Y. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-280-9_2 · Cited by 40 · see citing works

Modeling metastasis in the mouse

McClatchey, A. I. (1999) · Oncogene · doi:10.1038/sj.onc.1203086 · Cited by 32 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Chakrabarti, R., Celià-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B. G., Grady, J. J., et al. (2018) · Science · doi:10.1126/science.aan4153 · Cited by 196 · see citing works

Cancer Modeling‐on‐a‐Chip with Future Artificial Intelligence Integration

Fetah, K., DiPardo, B. J., Kongadzem, E.-M. L., Tomlinson, J. S., Elzagheid, A. I., Elmusrati, M. S., Khademhosseini, A., & Ashammakhi, N. A. (2019) · Small · doi:10.1002/smll.201901985 · Cited by 115 · see citing works

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Li, B., Xu, W., Lam, A. K.-Y., Wang, Y., Hu, H., Guan, X., Qin, Y., Saremi, N., Tsao, S. W., He, Q., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16333 · Cited by 107 · see citing works

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

Singh, S., Kumar, S., Srivastava, R. K., Nandi, A., Thacker, G., Murali, H., Kim, S., Baldeon, M. A., Tobias, J. W., Blanco, M. A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0495-y · Cited by 107 · see citing works

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer

Kumar, S., Srivastav, R. K., Wilkes, D. W., Ross, T., Kim, S., Kowalski, J., Chatla, S., Zhang, Q. H., Nayak, A., Guha, M., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0562-z · Cited by 96 · see citing works

Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer

Yao, Y.-Y., Guo, Q.-L., Cao, Y., Qiu, Y., Tan, R., Yu, Z., Zhou, Y.-X., & Lu, N. (2018) · Journal of experimental & clinical cancer research : CR · doi:10.1186/s13046-018-0960-7 · Cited by 95 · see citing works

Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects

Guha, M., Srinivasan, S., Raman, P., Jiang, Y., Kaufman, B. A., Taylor, D. M., Dong, D., Chakrabarti, R., Picard, M. A., Carstens, R. P., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.002 · Cited by 71 · see citing works

Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression

Singh, M., Mukundan, S., Jaramillo, M., Oesterreich, S., & Sant, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2304 · Cited by 68 · see citing works

Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer

Yao, Y., Zhao, K., Yu, Z., Ren, H., Zhao, L., Li, Z., Guo, Q., & Lu, N. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0574-5 · Cited by 56 · see citing works

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Cao, Y., Cao, W., Qiu, Y., Zhou, Y.-X., Guo, Q.-L., Gao, Y., & Lu, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104981 · Cited by 49 · see citing works

A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland

Tavera-Mendoza, L. E., & Brown, M. A. (2016) · Laboratory Animals · doi:10.1177/0023677216640706 · Cited by 27 · see citing works

Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma

Li, L., Wang, N., Zhu, M., Xiong, Y., Wang, F., Guo, G., Wang, X., & Gu, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04060-5 · Cited by 23 · see citing works

Cancer-on-a-Chip and Artificial Intelligence: Tomorrow's Cancer Management

Elmusrati, M. S., & Ashammakhi, N. A. (2018) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000004703 · Cited by 21 · see citing works

Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion

Rabêlo, A. C. S., Mertens‐Talcott, S. U., Chew, B. P., & Noratto, G. D. (2022) · Molecules · doi:10.3390/molecules27217245 · Cited by 18 · see citing works

CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

Lee, E.-M., Hong, J. J., Vargas, G. S., Sauerwald, N., Wei, Y., Hang, X., Theesfeld, C. L., Volmar, J. A., Miller, J. M., Wang, W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59972-z · Cited by 17 · see citing works

Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer

Silva, G. P. D. L., Sales-Dias, J., Casal, D., Alves, S., Domenici, G., Barreto, C., Matos, C., Lemos, A. R., Matias, A. T., Kucheryava, K., et al. (2021) · Cancers · doi:10.3390/cancers13164074 · Cited by 8 · see citing works

Current Insights in Murine Models for Breast Cancer: Present, Past and Future

Jain, M., & Goel, A. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128306053240604074142 · Cited by 5 · see citing works

Estrogen Regulated Genes Compel Apoptosis in Breast Cancer Cells, Whilst Stimulate Antitumor Activity in Peritumoral Immune Cells in a Janus-Faced Manner

Suba, Z. (2024) · Current Oncology · doi:10.3390/curroncol31090362 · Cited by 4 · see citing works

Experimental Induction of Mammary Carcinogenesis Using 7,12-Dimethylbenz(a)anthracene and Xenograft in Rats

Kontogeorgi, A., Boutas, I., Koufopoulos, N. I., Dimas, D., Sitara, K., Makrigiannakis, A., Goutas, D., & Kalantaridou, S. (2025) · Cureus · doi:10.7759/cureus.77648 · Cited by 2 · see citing works

Mouse models of breast cancer metastasis

Fantozzi, A., & Christofori, G. (2006) · Breast Cancer Research · doi:10.1186/bcr1530 · Cited by 336 · see citing works

Review Mouse models of breast cancer metastasis

Fantozzi, A., & Christofori, G. (2006)

Methods to Study Metastasis in Genetically Modified MicePreprint

Kabeer, F., Beverly, L. J., Darrasse-Jèze, G., & Podsypanina, K. (2016) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top069948 · Cited by 12 · see citing works

Xenotransplantation of Breast Cancers

Cariati, M., Marlow, R., & Dontu, G. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-080-5_38 · Cited by 9 · see citing works

Research Progress on Mouse Models of Breast Cancer Metastasis

Zhao, M., Qiao, H., & Zhang, J. (2024) · Proceedings of Anticancer Research · doi:10.26689/par.v8i6.8882