The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Liposomes for Specific Depletion of Macrophages from Organs and Tissues
Abstract
A liposome mediated macrophage "suicide" approach has been developed, based on the liposome mediated internalization of the small hydrophilic molecule clodronate in macrophages J Leukoc Biol 62:702, 1997. This molecule has a very short half life when released in the circulation, but does not easily cross phospholipid bilayers of liposomes or cell membranes. As a consequence, once ingested by a macrophage in a liposome encapsulated form, it will be accumulated within the cell as soon as the liposomes are digested with the help of its lysosomal phospholipases. At a certain intracellular clodronate concentration, the macrophage is eliminated by apoptosis. Given the fact that, neither the liposomal phospholipids chosen, nor clodronate are toxic to other (non-phagocytic) cells, this method has proven its efficacy and specificity for depletion of macrophage subsets in various organs. In several cases, organ specific depletion can be obtained by choosing the right administration route for the clodronate liposomes.
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Cites
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Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124
Self-citationMicroglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757
Litzinger, D. C., Buiting, A. M. J., van Rooijen, N., & Huang, L. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90038-8 · Cited by 546
Self-citationHuitinga, I., van Rooijen, N., de Groot, C. J., Uitdehaag, B. M., & Dijkstra, C. D. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.4.1025 · Cited by 506
Self-citationBisphosphonates in Bone Disease: From the Laboratory to the Patient
Fleisch, H. A. (1995) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 472
The liposome-mediated macrophage ‘suicide’ technique
Van Rooijen, N. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90178-6 · Cited by 441
Self-citationThepen, T., Van Rooijen, N., & Kraal, G. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.2.499 · Cited by 422
Self-citationvan Rooijen, N., Sanders, A., & van den Berg, T. K. (1996) · Journal of Immunological Methods · doi:10.1016/0022-1759(96)00056-7 · Cited by 407
Self-citationTran, E. H., Hoekstra, K., van Rooijen, N., Dijkstra, C. D., & Owens, T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3767 · Cited by 342
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Macrophages are required for adult salamander limb regeneration
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829
Jourdan, T., Godlewski, G., Cinar, R., Bertola, A., Szanda, G., Liu, J., Tam, J., Han, T., Mukhopadhyay, B., Skarulis, M. C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3265 · Cited by 388
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357
Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
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Metadata
- Authors
- van Rooijen, N., & Hendrikx, E.
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2009-11-21
- Volume
- 605
- Pages
- 189-203
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W174130975
- Cited by
- 379
- References
- 28
- FWCI
- 9.72
- Type
- book chapter
- Language
- en
- Open access
- closed
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- van Rooijen, N., & Hendrikx, E. (2010). Liposomes for Specific Depletion of Macrophages from Organs and Tissues. Methods in Molecular Biology. https://doi.org/10.1007/978-1-60327-360-2_13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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