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Cited by 164Barrier Structure and Function StudiesNerve injury and regenerationPeripheral Neuropathies and Disorders

The blood-nerve barrier: structure and functional significance

Weerasuriya, Ananda, Mizisin, Andrew P.·2011·Methods in Molecular Biology
DOI 10.1007/978-1-60761-938-3_6
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Abstract

The blood-nerve barrier (BNB) defines the physiological space within which the axons, Schwann cells, and other associated cells of a peripheral nerve function. The BNB consists of the endoneurial microvessels within the nerve fascicle and the investing perineurium. The restricted permeability of these two barriers protects the endoneurial microenvironment from drastic concentration changes in the vascular and other extracellular spaces. It is postulated that endoneurial homeostatic mechanisms regulate the milieu intérieur of peripheral axons and associated Schwann cells. These mechanisms are discussed in relation to nerve development, Wallerian degeneration and nerve regeneration, and lead neuropathy. Finally, the putative factors responsible for the cellular and molecular control of BNB permeability are discussed. Given the dynamic nature of the regulation of the permeability of the perineurium and endoneurial capillaries, it is suggested that the term blood-nerve interface (BNI) better reflects the functional significance of these structures in the maintenance of homeostasis within the endoneurial microenvironment.

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  • The perineurium plays a major role in peripheral nerve function and metabolism.

    “It also plays a major role in peripheral nerve function and metabolism [7, 8].”

    From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [7]

  • Important functions of the perineurium are to maintain a positive intrafascicular pressure relative to the endoneurium and to regulate the local environment by acting as a diffusion barrier to several substances.

    “Important functions of the perineurium are to maintain a positive intrafascicular pressure, relative to the endoneurium and regulate the local environment by acting as a diffusion barrier to several substances.”

    From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [7]

  • The blood-nerve barrier consists of endoneurial microvessels within the nerve fascicle and the investing perineurium; these microvessels regulate permeability and play an important role in the passage of substances from olfactory and trigeminal pathways into the CNS.

    “Therefore, particular attention must be given to studies of the blood–nerve barrier (BNB), which consists of endoneurial microvessels within the nerve fascicle and the investing perineurium [13]. These microvessels are actively involved in the mechanisms that regulate the permeability of the perineurium and endoneurial capillaries, and surely they play an important role in the passage of sub”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [13]

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Authors
Weerasuriya, A., & Mizisin, A. P.
Affiliations
  • Mercer University (US)
  • University of California San Diego (US)
Corresponding author
Weerasuriya, Ananda
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2010-11-12
Volume
686
Pages
149-173
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
DOI
10.1007/978-1-60761-938-3_6
OpenAlex
W86358223
Cited by
164
References
100
Citations by year
2026: 9 · 2025: 12 · 2024: 11 · 2023: 24 · 2022: 11 · 2021: 12 · 2020: 14 · 2019: 12 · 2018: 14 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 6
FWCI
14.69
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns030197-03)
  • U.S. Public Health Service (R01-DI2078374)
  • National Institute of Neurological Disorders and Stroke (R01-NS30197)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
blood-nerve barrier, perineurium, Schwann cells, milieu intérieur, nerve development, Wallerian degeneration, nerve regeneration, barrier permeability, peripheral nerves
MeSH terms
Animals, Humans, Peripheral Nerves, Blood-Nerve Barrier

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