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Cited by 209Nerve Injury and RehabilitationElasticity and Material ModelingNerve injury and regeneration

An in vitro mechanical and histological study of acute stretching on rabbit tibial nerve

Rydevik, Björn L., Kwan, Michael K., Myers, Robert R., Brown, Richard A., Triggs, Kevin J., Woo, Savio L‐Y., Garfin, Steven R.·1990·Journal of Orthopaedic Research®
DOI 10.1002/jor.1100080511
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Abstract

Peripheral nerves are often mechanically stretched in association with trauma to extremities, resulting in varying degrees of impairment of nerve function. However, little is known about the biomechanical properties of peripheral nerves and limits of stretching that the nerve may undergo before structural changes occur. Also, the injury pattern of nerves under stretching is poorly understood. In the present study, fresh rabbit tibial nerves (n = 18) were harvested. Nine nerves were stretched to failure in an INSTRON materials testing machine at a rate of 1 cm/min (strain rate of 0.5%/s). Load-deformation and stress-strain curves were determined. Histological examination by light microscopy of the stretched nerves as well as six normal control nerves and three clamped nonstretched control nerves was performed. The results show that the rabbit tibial nerves have an in situ strain of 11.0 +/- 1.5% and exhibit a nonlinear stress-strain relationship. After 20% strain, the curve becomes linear up to failure. The ultimate strain and tensile strength of the nerves were 38.5 +/- 2.0% and 11.7 +/- 0.7 MPa, respectively. At failure, the load dropped suddenly, but the specimens remained grossly intact. Histological analysis of the stretched nerves showed multiple ruptures of perineurial sheaths when compared to controls.

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Crossref · 10.1002/jor.1100080511

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29 of 29 references verified0 citation errors · 0 not checkable

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  • These complications have particularly been observed in larger nerve fibers and in chronically implanted intrafascicular devices.

    “These events have particularly been observed in larger nerve fibers [4, 31, 32] and in chronically implanted intrafascicular devices [30, 33, 34].”

    From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [4]

  • The perineurium consists of collagen and squamous cells that are interconnected by tight junctions (zonulae occludens) to prevent paracellular transport.

    “The perineurium consists of collagen and squamous cells that are interconnected by tight junctions ( zonulae occludens ) to prevent paracellular transport [3-6].”

    From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [4]

  • The innermost perineurial cells functionally contribute to the blood-nerve barrier, regulating the passage of nutrients to the endoneurial micro-environment.

    “The innermost perineurial cells functionally contribute to the blood-nerve barrier (BNB), like the blood-brain barrier in the central nervous system, regulating the passage of nutrients to the endoneurial micro-environment.”

    From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [4]

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Related

Authors
Rydevik, B. L., Kwan, M. K., Myers, R. R., Brown, R. A., Triggs, K. J., Woo, S. L., & Garfin, S. R.
Affiliations
University of California San Diego (US)
ORCID
Brown, Richard A.
Venue
Journal of Orthopaedic Research®
Publisher
Wiley
Published
1990-09
Volume
8
Issue
5
Pages
694-701
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1002/jor.1100080511
OpenAlex
W2046660728
Cited by
209
References
32
Citations by year
2026: 1 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 14 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 7
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5284 d)
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS018715, NS 18715)
Topics
  • Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
nerve stretching, tibial nerve, tensile strength, stress-strain behavior, ultimate strain, nerve injury, rabbits
MeSH terms
Animals, Biomechanical Phenomena, Nerve Fibers, Rabbits, Stress, Mechanical, Tibial Nerve

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