Hsp70: Anti-apoptotic and Tumorigenic Protein

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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

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Protein folding in the cell

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

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Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

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Caspases: killer proteases

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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

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Molecular Chaperones and Protein Quality Control

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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Novel Signal Transduction Pathway Utilized by Extracellular HSP70

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Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

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Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

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The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions

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CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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Pathways of chaperone-mediated protein folding in the cytosol

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Roles of heat-shock proteins in innate and adaptive immunity.

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Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

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Apoptosis signaling by death receptors

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Heat-shock protein 70 antagonizes apoptosis-inducing factor

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A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and BakPreprint

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Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

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Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death

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The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

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Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

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Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

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Heat Shock Protein 70 Surface-Positive Tumor Exosomes Stimulate Migratory and Cytolytic Activity of Natural Killer Cells

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Hsp70 exerts its anti‐apoptotic function downstream of caspase‐3‐like proteases

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Heat Shock Proteins 27 and 70: Anti-Apoptotic Proteins with Tumorigenic Properties

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CD91: a receptor for heat shock protein gp96

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Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

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Heat shock protein 70-associated peptides elicit specific cancer immunity.

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Escaping Cell Death: Survival Proteins in Cancer

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Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy

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HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

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Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90

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Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

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Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

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Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.

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Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function

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Molecular chaperones and the stress of oncogenesis

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Heat shock proteins as cellular lifeguards

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Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages1

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A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

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Cathepsin D Triggers Bax Activation, Resulting in Selective Apoptosis-inducing Factor (AIF) Relocation in T Lymphocytes Entering the Early Commitment Phase to Apoptosis

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Hsp70 Inhibits Heat-induced Apoptosis Upstream of Mitochondria by Preventing Bax Translocation

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Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death

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Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

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How death shapes life during development

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Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.

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Caspase Activation Is Required for Terminal Erythroid Differentiation

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Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

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Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

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Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells

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Heat Shock Proteins 70 and 90 Inhibit Early Stages of Amyloid β-(1–42) Aggregation in Vitro

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine

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70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

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Caspase-independent cell death in T lymphocytes

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Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways

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Injected cytochrome c induces apoptosis

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Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis

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Stress-Inducible Cellular Responses

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Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes

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The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

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Hsp72 functions as a natural inhibitory protein of c‐Jun N‐terminal kinase

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A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

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Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

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Atractyloside‐induced release of cathepsin B, a protease with caspase‐processing activity

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Triptolide Induces Pancreatic Cancer Cell Death via Inhibition of Heat Shock Protein 70

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Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy

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Not all J domains are created equal: Implications for the specificity of Hsp40–Hsp70 interactions

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Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

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Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human Fibroblasts

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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor

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Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases

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Anti-Inflammatory Effect of Heat Shock Protein Induction Is Related to Stabilization of IκBα Through Preventing IκB Kinase Activation in Respiratory Epithelial Cells

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Modulating Poly (ADP-Ribose) Polymerase Activity: Potential for the Prevention and Therapy of Pathogenic Situations Involving DNA Damage and Oxidative Stress

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Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72

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Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

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Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma

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Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design

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Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells

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Recombinant Human Heat Shock Protein 60 Does Not Induce the Release of Tumor Necrosis Factor α from Murine Macrophages

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Heat Shock Protein-chaperoned Peptides but Not Free Peptides Introduced into the Cytosol Are Presented Efficiently by Major Histocompatibility Complex I Molecules

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Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells

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The Receptor for Heat Shock Protein 60 on Macrophages Is Saturable, Specific, and Distinct from Receptors for Other Heat Shock Proteins

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Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

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Hsp70 Overexpression Sequesters AIF and Reduces Neonatal Hypoxic/Ischemic Brain Injury

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Interaction of Heat Shock Protein 70 Peptide with NK Cells Involves the NK Receptor CD94

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Microinjection of Cathepsin D Induces Caspase-Dependent Apoptosis in Fibroblasts

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Hsp70 interactions with the p53 tumour suppressor protein

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Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak

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Alternative Mechanism by which IFN-γ Enhances Tumor Recognition: Active Release of Heat Shock Protein 72

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Hsp72 and Stress Kinase c-jun N-Terminal Kinase Regulate the Bid-Dependent Pathway in Tumor Necrosis Factor-Induced Apoptosis

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Heat Shock Protein Hsp72 Is a Negative Regulator of Apoptosis Signal-Regulating Kinase 1

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Over‐expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells

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Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability

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Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

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Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells

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Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8+ T Cell Effector Function

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Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers

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The Turn Motif Is a Phosphorylation Switch That Regulates the Binding of Hsp70 to Protein Kinase C

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FANCC interacts with Hsp70 to protect hematopoietic cells from IFN‐γ/TNF‐α‐mediated cytotoxicity

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Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling

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Distinct hsp70 Domains Mediate Apoptosis-inducing Factor Release and Nuclear Accumulation

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Heat shock proteins refine the danger theory

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Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip

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Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes

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HSP70 Deficiency Results in Activation of c-Jun N-terminal Kinase, Extracellular Signal-regulated Kinase, and Caspase-3 in Hyperosmolarity-induced Apoptosis

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The Anti-apoptotic Function of Hsp70 in the Interferon-inducible Double-stranded RNA-dependent Protein Kinase-mediated Death Signaling Pathway Requires the Fanconi Anemia Protein, FANCC

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Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10/ mice and Rag-2/ mice reconstituted with CD4+CD45RBhigh T cells

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GRP94/gp96 Elicits ERK Activation in Murine Macrophages

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Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells

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Surface Expression of Hsp25 and Hsp72 Differentially Regulates Tumor Growth and Metastasis

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Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia

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Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

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Induction of hsp70-Mediated Th17 Autoimmunity Can Be Exploited as Immunotherapy for Metastatic Prostate Cancer

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Smac/Diablo Antagonizes Ubiquitin Ligase Activity of Inhibitor of Apoptosis Proteins

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Regulation of the human apoptotic DNase/RNase Endonuclease G: involvement of Hsp70 and ATP

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Characterization of a Receptor for Heat Shock Protein 70 on Macrophages and Monocytes

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Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells

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Mortalin sensitizes human cancer cells to MKT-077-induced senescence

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Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma

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Co-translational Folding of Caspase-activated DNase with Hsp70, Hsp40, and Inhibitor of Caspase-activated DNase

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Heat shock protein 70 inhibits the nuclear import of apoptosis‐inducing factor to avoid DNA fragmentation in TF‐1 cells during erythropoiesis

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Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.

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Quercetin Enhances Susceptibility to NK Cell-mediated Lysis of Tumor Cells Through Induction of NKG2D Ligands and Suppression of HSP70

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A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro

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High-Affinity Interactions between Peptides and Heat Shock Protein 70 Augment CD8+ T Lymphocyte Immune Responses

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Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines

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AEG3482 Is an Antiapoptotic Compound that Inhibits Jun Kinase Activity and Cell Death through Induced Expression of Heat Shock Protein 70

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Killing of Normal Melanocytes, Combined with Heat Shock Protein 70 and CD40L Expression, Cures Large Established Melanomas

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Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells

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Natural killer cells play a key role in the antitumor immunity generated by chaperone‐rich cell lysate vaccination

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Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70

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Both CD4 + and CD8 + T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors

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Geldanamycin inhibits TGF-β signaling through induction of Hsp70

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Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

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Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma

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Heat Shock Proteins (HSP70 and HSP27) as Markers of Epithelial Dysplasia in Oral Leukoplakia

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Fusion proteins of Hsp70 with tumor-associated antigen acting as a potent tumor vaccine and the C‐terminal peptide-binding domain of Hsp70 being essential in inducing antigen-independent anti-tumor response in vivo

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Helicobacter pylori inhibits expression of heat shock protein 70 (HSP70) in human epithelial cell line. Importance of Cag A protein.

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Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya

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The Intrinsic Pathway of Apoptosis

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Untitled work

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Heat Shock Proteins and Cancer

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Heat Shock Protein 70 Serum Levels Differ Significantly in Patients with Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma

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Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells

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Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation

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Panel of autoantibodies against multiple tumor‐associated antigens for detecting gastric cancer

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Heat Shock Proteins: Conditional Mediators of Inflammation in Tumor Immunity

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Varicocoele and oxidative stress: New perspectives from animal and human studies

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Extracellular HSP70/HSP70-PCs Promote Epithelial-Mesenchymal Transition of Hepatocarcinoma Cells

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Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors

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Testicular torsion and reperfusion: evidences for biochemical and molecular alterations

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The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

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The role of heat shock proteins in metastatic colorectal cancer: A review

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Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

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Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B

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Mechanism of graphene‐induced cytotoxicity: Role of endonucleases

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Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer

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Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice

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Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) Concepts

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ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling

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Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer

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Anticancer Activity of Lichen Metabolites and Their Mechanisms at the Molecular Level

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Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

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The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo

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Triptolide reduces the viability of osteosarcoma cells by reducing MKP-1 and Hsp70 expression

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Differentially expressed miRNAs in oxygen-induced retinopathy newborn mouse models

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The Role of HSP70 in the Protective Effects of NVP-AUY922 on Multiple Organ Dysfunction Syndrome in Endotoxemic Rats

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A novel method to assay molecular chaperone activity of HSP70: Evaluation of drug resistance in cancer treatment

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From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy

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Optimum health and inhibition of cancer progression by microbiome and resveratrol

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Exosomes: potential diagnostic markers and drug carriers for adenomyosis

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Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specific apoptosis

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Lichens: A promising source of anti-cancerous activity and their molecular mechanisms

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Interplay of Oxidative Stress, Inflammation, and Autophagy in RAW 264.7 Murine Macrophage Cell Line Challenged with Si/SiO2 Quantum Dots

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HSP70—A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli

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Proteomic insights into non-small cell lung cancer: New ideas for cancer diagnosis and therapy from a functional viewpoint

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HSP70 as a Diagnostic and Prognostic Marker in Egyptian Women With Breast Cancer

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Ultrasound Targeted Microbubble Destruction for Novel Dual Targeting of HSP72 and HSC70 in Prostate Cancer

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Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70

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Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis

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2-Methoxyestradiol Damages DNA in Glioblastoma Cells by Regulating nNOS and Heat Shock Proteins

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Regulation of heat shock protein-70 gene transcripts in breast cancer cells during hypo and hyperthermia exposure

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Quantitative Immunomorphological Analysis of Heat Shock Proteins in Thyroid Follicular Adenoma and Carcinoma Tissues Reveals Their Potential for Differential Diagnosis and Points to a Role in Carcinogenesis

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HSP70 In triple negative breast cancer: Prognostic value and clinical significance

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Heat shock protein 70 modulates neural progenitor cells dynamics in human neuroblastoma SH‐SY5Y cells exposed to high glucose content

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Revealing GRP75-Mediated Mitochondrial Stability That Promotes Breast Cancer Survival through Subcellular Anchoring of 70 kDa Heat Shock Protein Inhibitors

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Synergetic support of cartilage homeostasis via coupled thermal-pressure stimuli: a transcriptomic study in human cartilage explants

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Heat Shock Response Agents and the Diseases

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Heat Shock Protein 70 and Cancer

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Muscular apoptosis but not oxidative stress increases with old age in a long-lived diver, the Weddell seal

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Policosanol ameliorates Post-Myocardial Infarction-induced neuronal damage and cognitive impairment in rats via suppressing miRNA-1

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Molecular Approaches to Target Heat Shock Proteins for Cancer Treatment

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Heat shock protein 70 is involved in polaprezinc driven cell protection against Helicobacter pylori-induced injury

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Role of radio-frequency electromagnetic waves in causing oxidative stress

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Molecular Chaperones and Ubiquitin Proteasome System in Tumor Biogenesis: An Overview

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Combinational treatments for breast cancer

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Synthesis and Evaluation of Physicochemical Properties of a Solid Lipid Nanocarrier Containing a Sulfonamide Derivative and Investigation of Its Effect on Breast Cancer Cells

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Controlled Molecular Targeting of Inducible Heat Shock Proteins

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Investigation of the apoptosis induction potential of synthetic sorafenib-derived compounds in breast cancer cells

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Hsp70: A Cancer Target Inside and Outside the Cell

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Hsp70 and Hsp27: Emerging Targets in Cancer Therapy

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Heat Shock Proteins 27 and 70: Anti-Apoptotic Proteins with Tumorigenic Properties

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HSP70 AND HSP27 AS PHARMACOLOGICAL TARGETS IN APOPTOSIS MODULATION FOR CANCER THERAPY Heat shock proteins and Cancer

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Hsp70 and Hsp27 as pharmacological targets in apoptosis modulation for cancer therapy

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