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Cited by 167Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorChemical Synthesis and Analysis

What are neuropeptides?

Burbach, J. Peter H.·2011·Methods in molecular biology
DOI 10.1007/978-1-61779-310-3_1
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Abstract

We know neuropeptides now for over 40 years as chemical signals in the brain. The discovery of neuropeptides is founded on groundbreaking research in physiology, endocrinology, and biochemistry during the last century and has been built on three seminal notions: (1) peptide hormones are chemical signals in the endocrine system; (2) neurosecretion of peptides is a general principle in the nervous system; and (3) the nervous system is responsive to peptide signals. These historical lines have contributed to how neuropeptides can be defined today: "Neuropeptides are small proteinaceous substances produced and released by neurons through the regulated secretory route and acting on neural substrates." Thus, neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides. In addition, among cytokines, peptide hormones, and growth factors there are several subfamilies of peptides displaying most of the hallmarks of neuropeptides, for example neural chemokines, cerebellins, neurexophilins, and granins. All classical neuropeptides as well as putative neuropeptides from the latter families are presented as a resource.

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  • By far the largest family of neuromodulator molecules known comprises the evolutionarily ancient proteinaceous signaling molecules known as neuropeptides.

    “By far the largest family of neuromodulator molecules known, however, comprises the evolutionarily ancient proteinaceous signaling molecules known as neuropeptides”

    From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Burbach, 2011

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Authors
Burbach, J. P. H.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Burbach, J. Peter H.
ORCID
Burbach, J. Peter H.
Venue
Methods in molecular biology
Publisher
Humana Press
Published
2011
Volume
789
Pages
1-36
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
DOI
10.1007/978-1-61779-310-3_1
OpenAlex
W8789689
Cited by
167
References
42
Citations by year
2026: 9 · 2025: 13 · 2024: 16 · 2023: 20 · 2022: 18 · 2021: 13 · 2020: 25 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 1 · 2012: 4
FWCI
3.59
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
Keywords
neuropeptides, neuropeptide precursors, regulated secretory pathway, neurosecretion, peptide hormones, neuronal signaling, neuropeptide families, cerebellin, granins
MeSH terms
Animals, Chromogranins, Humans, Models, Biological, Nerve Tissue Proteins, Neuropeptides, Chemokines

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