Deep Learning Based Inter-modality Image Registration Supervised by Intra-modality Similarity
Open accessAbstract
Non-rigid inter-modality registration can facilitate accurate information fusion from different modalities, but it is challenging due to the very different image appearances across modalities. In this paper, we propose to train a non-rigid inter-modality image registration network, which can directly predict the transformation field from the input multimodal images, such as CT and MR images. In particular, the training of our inter-modality registration network is supervised by intra-modality similarity metric based on the available paired data, which is derived from a pre-aligned CT and MR dataset. Specifically, in the training stage, to register the input CT and MR images, their similarity is evaluated on the warped MR image and the MR image that is paired with the input CT. So that, the intra-modality similarity metric can be directly applied to measure whether the input CT and MR images are well registered. Moreover, we use the idea of dual-modality fashion, in which we measure the similarity on both CT modality and MR modality. In this way, the complementary anatomies in both modalities can be jointly considered to more accurately train the inter-modality registration network. In the testing stage, the trained inter-modality registration network can be directly applied to register the new multimodal images without any paired data. Experimental results have shown that, the proposed method can achieve promising accuracy and efficiency for the challenging non-rigid inter-modality registration task and also outperforms the state-of-the-art approaches.
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In medical imaging applications with human tissues, registration of slices must be performed in an elastic form.
“In medical imaging applications with human tissues, registration of slices must be performed in an elastic form [195].”
From AI in Medical Imaging Informatics: Current Challenges and Future Directions (2020) · cites this paper as [195]
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Wang, Y., Zhang, Y., Ma, C., Wang, R., Guo, Z., Shen, Y., Wang, M., & Meng, H. (2023) · International Journal of Neural Systems · doi:10.1142/s0129065724500011 · Cited by 4 · see citing works
CrossModalNet: exploiting quality preoperative images for multimodal image registration
Sun, J., Liu, C., Li, C., Lu, Z., He, M., Gao, L., Lin, T., Sui, J., Xie, K., & Ni, X. (2021) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ac195e · Cited by 4 · see citing works
FAMAFuse: Functional-Anatomical Multiscale Attention for Multimodal Image Fusion
Kamara, A. A., He, S., & Fofanah, A. J. (2025) · IEEE Transactions on Circuits and Systems for Video Technology · doi:10.1109/tcsvt.2025.3626562 · Cited by 3 · see citing works
Zhang, X., Gosnell, J. M., Nainamalai, V., Page, S., Huang, S., Haw, M. P., Peng, B., Vettukattil, J. J., & Jiang, J. (2023) · Diagnostics · doi:10.3390/diagnostics13182981 · Cited by 3 · see citing works
Wu, C., & Li, Z. (2025) · The Visual Computer · doi:10.1007/s00371-025-04183-2 · Cited by 3 · see citing works
Unpaired Cross-Modal Interaction Learning for COVID-19 Segmentation on Limited CT Images
Guan, Q., Xie, Y., Yang, B., Zhang, J., Liao, Z., Wu, Q., & Xia, Y. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-43898-1_58 · Cited by 3 · see citing works
Intraoperative CT Augmentation for Needle-Based Liver Interventions
Hadramy, S. E., Verde, J. M., Padoy, N., & Cotin, S. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-43996-4_28 · Cited by 3 · see citing works
Ji, Y., Zhu, Z., & Wei, Y. (2022) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi52829.2022.9761527 · Cited by 3 · see citing works
Communal Domain Learning for Registration in Drifted Image Spaces
Mansoor, A., & Linguraru, M. G. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-32692-0_55 · Cited by 3 · see citing works
Modern Approaches for Thoracic Image Registration and Respiratory Motion Management in Oncology
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Pan, T., Thomas, M. A., Lü, Y., & Luo, D. (2025) · EJNMMI Physics · doi:10.1186/s40658-025-00797-6 · Cited by 2 · see citing works
Jiang, M., Gao, S., Zhang, X., Wang, X., Hu, Q., & Wang, W. (2025) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2025.112684 · Cited by 2 · see citing works
Self-supervised Probe Pose Regression via Optimized Ultrasound Representations for US-CT Fusion
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Huang, Q., Ren, L., Quan, T., Yang, M., Yuan, H., & Cao, K. (2024) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545824500226 · Cited by 2 · see citing works
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New Attempts in Solving Image Recognition Tasks
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- Authors
- Cao, X., Yang, J., Wang, L., Xue, Z., Wang, Q., & Shen, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Northwestern Polytechnical University (CN)
- United Imaging Intelligence (China) (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Shen, Dinggang
- Venue
- Lecture Notes in Computer Science
- Publisher
- Springer International Publishing
- Published
- 2018
- Volume
- 11046
- Pages
- 55-63
- ISSN
- 0302-9743 (ISSN-L)
- 1611-3349
- PMC
- PMC6516490
- OpenAlex
- W2798741430
- Cited by
- 123
- References
- 10
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 19 · 2023: 21 · 2022: 18 · 2021: 14 · 2020: 16 · 2019: 11 · 2018: 1
- FWCI
- 3.16
- Type
- conference paper
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lecture notes in computer science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Institute on Aging (RF1AG053867)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Physical Sciences › Computer Science › Artificial Intelligence › Domain Adaptation and Few-Shot Learning
- Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
- Keywords
- non-rigid registration, CT-MRI registration, paired training data, multimodal image fusion, deep learning registration
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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