Deep learning in medical image registration: a review
Open accessAbstract
This paper presents a review of deep learning (DL)-based medical image registration methods. We summarized the latest developments and applications of DL-based registration methods in the medical field. These methods were classified into seven categories according to their methods, functions and popularity. A detailed review of each category was presented, highlighting important contributions and identifying specific challenges. A short assessment was presented following the detailed review of each category to summarize its achievements and future potential. We provided a comprehensive comparison among DL-based methods for lung and brain registration using benchmark datasets. Lastly, we analyzed the statistics of all the cited works from various aspects, revealing the popularity and future trend of DL-based medical image registration.
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Previous reviews lack a summary of public datasets for benchmarking registration algorithms.
“On one hand, these reviews lack a summary of the public dataset for benchmarking registration algorithms.”
From A review of deep learning-based deformable medical image registration (2022) · cites this paper as [20]
The Benchmark section says the review summarizes brain registration datasets. Its Brain subsection says table 11 lists datasets to facilitate benchmarking, and the Statistics section notes the availability of public brain datasets. This contradicts the claim that this review lacks such a summary. (LLM, conf=0.90)
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Experimental — accuracy not yet measuredDL for medical image registration has numerous applications.
“DL for medical image registration has numerous applications, which were listed by some review papers [320–322].”
From Review of deep learning: concepts, CNN architectures, challenges, applications, future directions (2021) · cites this paper as [320]
Previous reviews about deep learning-based medical image registration literature have been published.
“Though previous reviews about deep learning-based medical image registration literature have been published (19–22), there are still some deficiencies.”
From A review of deep learning-based deformable medical image registration (2022) · cites this paper as [20]
Some details of the selected literature were missing in previous reviews.
“On the other hand, some details of the selected literature were missing.”
From A review of deep learning-based deformable medical image registration (2022) · cites this paper as [20]
The Introduction says that few previous reviews focused specifically on deep learning in medical image registration, and describes this review's aim to provide detailed statistics. It does not say that previous reviews omitted details of their selected literature. Searches for missing details in previous reviews found no passage addressing that point; page numbers were unavailable in our copy. (LLM, conf=0.73)
Experimental — accuracy not yet measured
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Weakly Supervised Learning in Deformable EM Image Registration Using Slice Interpolation
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Gong, L., Wang, H., Peng, C., Dai, Y., Ding, M., Sun, Y., Yang, X., & Zheng, J. (2017) · BioMedical Engineering OnLine · doi:10.1186/s12938-016-0308-5 · Cited by 16 · see citing works
Self-citationCNN Driven Sparse Multi-level B-Spline Image Registration
Jiang, P., & Shackleford, J. (2018) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2018.00967 · Cited by 16 · see citing works
4D-CT Deformable Image Registration Using an Unsupervised Deep Convolutional Neural Network
Lei, Y., Fu, Y., Harms, J. M., Wang, T., Curran, W. J., Liu, T., Higgins, K. A., & Yang, X. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-32486-5_4 · Cited by 16 · see citing works
Self-citationMotion Tracking and Strain Map Computation for Quasi-Static Magnetic Resonance Elastography
Fu, Y., Chui, C., Teo, C. L., et al. (2011) · Lecture notes in computer science · doi:10.1007/978-3-642-23623-5_54 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Review of deep learning: concepts, CNN architectures, challenges, applications, future directions
Alzubaidi, L., Zhang, J., Humaidi, A. J., Al-Dujaili, A., Duan, Y., Al-Shamma, O., Santamaría, J., Fadhel, M. A., Al-Amidie, M., & Farhan, L. (2021) · Journal of Big Data · doi:10.1186/s40537-021-00444-8 · Cited by 7,906 · see citing works
Unberath, M., Gao, C., Hu, Y., Judish, M., Taylor, R. H., Armand, M., & Grupp, R. (2021) · Frontiers in Robotics and AI · doi:10.3389/frobt.2021.716007 · Cited by 102 · see citing works
“Inspiration can be drawn from the applications of 3D/3D and 2D/2D deformable image registration [110, 111, 112], where machine learning techniques have dominated most existing research into registration uncertainty.”
BackgroundA review of deep learning-based deformable medical image registration
Zou, J., Gao, B., Song, Y., & Qin, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1047215 · Cited by 91 · see citing works
Fu, Y., Lei, Y., Wang, T., Patel, P., Jani, A. B., Mao, H., Curran, W. J., Liu, T., & Yang, X. (2021) · Medical Image Analysis · doi:10.1016/j.media.2020.101845 · Cited by 75 · see citing works
Self-citationHsu, S.-T., Su, Y.-J., Hung, C.-H., Chen, M.-J., Lu, C.-H., & Kuo, C.-E. (2022) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-022-02047-6 · Cited by 58 · see citing works
Deep reinforcement learning and its applications in medical imaging and radiation therapy: a survey
Xu, L., Zhu, S., & Wen, N. (2022) · Physics in Medicine & Biology · doi:10.1088/1361-6560/ac9cb3 · Cited by 35 · see citing works
- Authors
- Fu, Y., Lei, Y., Wang, T., Curran, W. J., Liu, T., & Yang, X.
- Affiliations
- Emory University (US)
- Corresponding author
- Lei, Yang
- Yang, Xiaofeng
- Venue
- Physics in Medicine & Biology
- Publisher
- IOP Publishing
- Published
- 2020-10-07
- Volume
- 65
- Issue
- 20
- Pages
- 20TR01
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- PMC
- PMC7759388
- OpenAlex
- W3013056581
- Cited by
- 661
- References
- 213
- Citations by year
- 2026: 55 · 2025: 114 · 2024: 131 · 2023: 132 · 2022: 112 · 2021: 93 · 2020: 22
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Cancer Institute of the National Institutes of Health (R01CA215718)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Domain Adaptation and Few-Shot Learning
- Keywords
- medical image registration, deep learning, brain registration, benchmark dataset, research trends
- MeSH terms
- Deep Learning, Brain, Diagnostic Imaging, Humans, Image Processing, Computer-Assisted
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