CoChat
Sign Up
Cited by 46Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

TRPC Channels: Integrators of Multiple Cellular Signals

Soboloff, J., Spassova, M., Hewavitharana, T., He, L. -P., Luncsford, P., Xu, W., Venkatachalam, K., van Rossum, D., Patterson, R. L., Gill, D. L.·2007·Handbook of Experimental Pharmacology
DOI 10.1007/978-3-540-34891-7_34
Open this paper in CoChat — free account

Abstract

TRPC channels are ubiquitously expressed among cell types and mediate signals in response to phospholipase C (PLC)-coupled receptors. TRPC channels function as integrators of multiple signals resulting from receptor-induced PLC activation, which catalyzes the breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 depletes Ca2+ stores and TRPC3 channels can be activated by store-depletion. InsP3 also activates the InsP3 receptor, which may undergo direct interactions with the TRPC3 channel, perhaps mediating store-dependence. The other PLC product, DAG, has a direct non-PKC-dependent activating role on TRPC3 channels likely by direct binding. DAG also has profound effects on the TRPC3 channel through PKC. Thus PKC is a powerful inhibitor of most TRPC channels and DAG is a dual regulator of the TRPC3 channel. PLC-mediated DAG results in rapid channel opening followed later by a slower DAG-induced PKC-mediated deactivation of the channel. The decreased level of PIP2 from PLC activation also has an important modifying action on TRPC3 channels. Thus, the TRPC3 channel and PLCgamma form an intermolecular PH domain that has high specificity for binding PIP2. This interaction allows the channel to be retained within the plasma membrane, a further operational control factor for TRPC3. As nonselective cation channels, TRPC channel opening results in the entry of both Na+ and Ca2+ ions. Thus, while they m…

Overview

Integrity signals

Registry

Crossref · 10.1007/978-3-540-34891-7_34

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1 references

Research works printed but not linked: 65

  1. Bakowski D, Glitsch MD, Parekh AB (2001) An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current ICRAC in RBL-1 cells. J Physiol 532:55–71 · DOI
  2. Beech DJ (2005) Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol 32:597–603 · DOI
  3. Beech DJ, Muraki K, Flemming R (2004) Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559:685–706 · DOI
  4. Berridge MJ (2001) The versatility and complexity of calcium signalling. Novartis Found Symp 239:52–159 · DOI
  5. Berridge MJ (2002) The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32:235–249 · DOI
  6. Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4:517–529 · DOI
  7. Boulay G, Brown DM, Qin N, Jiang M, Dietrich A, Zhu MX, Chen Z, Birnbaumer M, Mikoshiba K, Birnbaumer L (1999) Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc Natl Acad Sci U S A 96:14955–14960 · DOI
  8. Broad LM, Braun FJ, Lievremont JP, Bird GS, Kurosaki T, Putney JW Jr (2001) Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry. J Biol Chem 276:15945–15952 · DOI
  9. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517–524 · DOI · Paper page
  10. Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432:723–730 · DOI
  11. Dietrich A, Mederos YSM, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L (2005) Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol 25:6980–6989 · DOI
  12. He LP, Hewavitharana T, Soboloff J, Spassova MA, Gill DL (2005) A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem 280:10997–11006 · DOI
  13. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279:18887–18894 · DOI
  14. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259–263 · DOI
  15. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res 88:325–332 · DOI
  16. Ishikawa J, Ohga K, Yoshino T, Takezawa R, Ichikawa A, Kubota H, Yamada T (2003) A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol 170:4441–4449 · DOI
  17. Jung S, Strotmann R, Schultz G, Plant TD (2002) TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Am J Physiol Cell Physiol 282:C347–359 · DOI
  18. Jung S, Muhle A, Schaefer M, Strotmann R, Schultz G, Plant TD (2003) Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem 278:3562–3571 · DOI
  19. Kahr H, Schindl R, Fritsch R, Heinze B, Hofbauer M, Hack ME, Mortelmaier MA, Groschner K, Peng JB, Takanaga H, Hediger MA, Romanin C (2004) CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J Physiol 557:121–132 · DOI
  20. Kiselyov K, Mignery GA, Zhu MX, Muallem S (1999) The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol Cell 4:423–429 · DOI
  21. Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A 99:6376–6381 · DOI
  22. Liman ER, Innan H (2003) Relaxed selective pressure on an essential component of pheromone transduction in primate evolution. Proc Natl Acad Sci U S A 100:3328–3332 · DOI
  23. Ma HT, Patterson RL, van Rossum DB, Birnbaumer L, Mikoshiba K, Gill DL (2000) Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science 287:1647–1651 · DOI
  24. Ma HT, Venkatachalam K, Li HS, Montell C, Kurosaki T, Patterson RL, Gill DL (2001) Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels. J Biol Chem 276:18888–18896 · DOI
  25. Ma HT, Venkatachalam K, Parys JB, Gill DL (2002) Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J Biol Chem 277:6915–6922 · DOI
  26. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 7:179–185 · DOI
  27. Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15:231–268 · DOI
  28. Montell C (2001) Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE 2001:RE1 · DOI
  29. Montell C, Birnbaumer L, Flockerzi V (2002a) The TRP channels, a remarkably functional family. Cell 108:595–598 · DOI
  30. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX (2002b) A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9:229–231 · DOI
  31. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359–27370 · DOI
  32. Parekh AB, Penner R (1997) Store depletion and calcium influx. Physiol Rev 77:901–930 · DOI
  33. Parekh AB, Putney JW Jr (2005) Store-operated calcium channels. Physiol Rev 85:757–810 · DOI · Paper page
  34. Patterson RL, van Rossum DB, Ford DL, Hurt KJ, Bae SS, Suh PG, Kurosaki T, Snyder SH, Gill DL (2002) Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell 111:529–541 · DOI · Paper page
  35. Prakriya M, Lewis RS (2001) Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP3 receptors. J Physiol 536:3–19 · DOI
  36. Putney JW Jr (2001) Pharmacology of capacitative calcium entry. Mol Interv 1:84–94
  37. Putney JW Jr (2004) The enigmatic TRPCs: multifunctional cation channels. Trends Cell Biol 14:282–286 · DOI
  38. Putney JW Jr, Broad LM, Braun FJ, Lievremont JP, Bird GS (2001) Mechanisms of capacitative calcium entry. J Cell Sci 114:2223–2229 · DOI
  39. Reading SA, Earley S, Waldron BJ, Welsh DG, Brayden JE (2005) TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries. Am J Physiol Heart Circ Physiol 288:H2055–2061 · DOI
  40. Schaefer ML, Wong ST, Wozniak DF, Muglia LM, Liauw JA, Zhuo M, Nardi A, Hartman RE, Vogt SK, Luedke CE, Storm DR, Muglia LJ (2000) Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice. J Neurosci 20:4809–4820 · DOI · Paper page
  41. Schindl R, Kahr H, Graz I, Groschner K, Romanin C (2002) Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca2+ release-activated Ca2+ channel) channels. J Biol Chem 277:26950–26958 · DOI
  42. Soboloff J, Spassova M, Xu W, He LP, Cuesta N, Gill DL (2005) Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem 280:39786–39794 · DOI
  43. Spassova MA, Soboloff J, He LP, Hewavitharana T, Xu W, Venkatachalam K, van Rossum DB, Patterson RL, Gill DL (2004) Calcium entry mediated by SOCs and TRP channels: variations and enigma. Biochim Biophys Acta 1742:9–20 · DOI
  44. Stowers L, Holy TE, Meister M, Dulac C, Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295:1493–1500 · DOI
  45. Sugawara H, Kurosaki M, Takata M, Kurosaki T (1997) Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16:3078–3088 · DOI
  46. Suh PG, Hwang JI, Ryu SH, Donowitz M, Kim JH (2001) The roles of PDZ-containing proteins in PLC-beta-mediated signaling. Biochem Biophys Res Commun 288:1–7 · DOI
  47. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX (2001) Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem 276:21303–21310 · DOI
  48. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000) Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275:37559–37564 · DOI
  49. van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, Snyder SH (2005) Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature 434:99–104 · DOI
  50. Vazquez G, Lievremont JP, St JBG, Putney JW Jr (2001) Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes. Proc Natl Acad Sci U S A 98:11777–11782 · DOI
  51. Vazquez G, Wedel BJ, Trebak M, St John Bird G, Putney JW Jr (2003) Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. J Biol Chem 278:21649–21654 · DOI
  52. Vazquez G, Wedel BJ, Kawasaki BT, Bird GS, Putney JW Jr (2004) Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels. J Biol Chem 279:40521–40528 · DOI
  53. Venkatachalam K, Ma HT, Ford DL, Gill DL (2001) Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells. J Biol Chem 276:33980–33985 · DOI
  54. Venkatachalam K, van Rossum DB, Patterson RL, Ma HT, Gill DL (2002) The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol 4:E263–272 · DOI
  55. Venkatachalam K, Zheng F, Gill DL (2003) Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 278:29031–29040 · DOI
  56. Venkatachalam K, Zheng F, Gill DL (2004) Control of TRPC and store-operated channels by protein kinase C. Novartis Found Symp 258:172–185 · DOI
  57. Voets T, Prenen J, Fleig A, Vennekens R, Watanabe H, Hoenderop JG, Bindels RJ, Droogmans G, Penner R, Nilius B (2001) CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J Biol Chem 276:47767–47770 · DOI
  58. Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90:248–250 · DOI
  59. Xu XZ, Li HS, Guggino WB, Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89:1155–1164 · DOI
  60. Yue L, Peng JB, Hediger MA, Clapham DE (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410:705–709 · DOI
  61. Zagranichnaya TK, Wu X, Villereal ML (2005) Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem 280:29559–29569 · DOI
  62. Zhang L, Saffen D (2001) Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization. J Biol Chem 276:13331–13339 · DOI
  63. Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani E, Birnbaumer L, Zhu MX (2001) Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci U S A 98:3168–3173 · DOI
  64. Zitt C, Halaszovich CR, Luckhoff A (2002) The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry. Prog Neurobiol 66:243–264 · DOI
  65. Zitt C, Strauss B, Schwarz EC, Spaeth N, Rast G, Hatzelmann A, Hoth M (2004) Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem 279:12427–12437 · DOI

Cited by

Sorted by citations

Metadata

Authors
Soboloff, J., Spassova, M., Hewavitharana, T., He, L. P., Luncsford, P., Xu, W., Venkatachalam, K., van Rossum, D., Patterson, R. L., & Gill, D. L.
Affiliations
  • University of Maryland, Baltimore (US)
  • Johns Hopkins University (US)
  • Pennsylvania State University (US)
Corresponding author
Gill, D. L.
ORCID
Venue
Handbook of Experimental Pharmacology
Publisher
Springer Berlin Heidelberg
Published
2007
Issue
179
Pages
575-591
ISSN
0171-2004 (ISSN-L)
DOI
10.1007/978-3-540-34891-7_34
OpenAlex
W38835698
Cited by
46
References
1
Citations by year
2025: 1 · 2024: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
4.02
Type
book chapter
Language
en
Open access
closed
Locations
  • Handbook of experimental pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL055426, HL55426)
  • National Institute of Allergy and Infectious Diseases (AI 058173, R01AI058173)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
TRPC channels, TRPC3, phospholipase C, phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate, diacylglycerol, protein kinase C, store-operated calcium entry, IP3 receptor, channel deactivation, plasma membrane retention, cation channels, membrane potential
MeSH terms
Animals, Biotransformation, Cell Physiological Phenomena, Humans, Type C Phospholipases, Protein Kinase C, Signal Transduction, Inositol 1,4,5-Trisphosphate, Transient Receptor Potential Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review