The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An Overview of the Molecular Mechanism of Autophagy
Open accessAbstract
Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle, an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome, for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.
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Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Autophagy fights disease through cellular self-digestion
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Self-citationInduction of autophagy and inhibition of tumorigenesis by beclin 1
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The role of autophagy during the early neonatal starvation period
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Selective degradation of mitochondria by mitophagy
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Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
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The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy
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“6), although it is not essential for the latter process to occur (Hanada et al. 2007).”
Background
Cited by
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Parzych, K. R., & Klionsky, D. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5371 · Cited by 2,521
Self-citationThe microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003
“In response to nutrient deprivation, AMPK activation induces autophagy, which is a catabolic process where the cell degrades its own cellular components in an attempt to maintain energy homeostasis (He and Klionsky, 2009; Yang and Klionsky, 2009).”
Mammalian autophagy: core molecular machinery and signaling regulation
Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956
Self-citationGalectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
Thurston, T. L. M., Wandel, M. P., von Muhlinen, N., Foeglein, Á., & Randow, F. (2012) · Nature · doi:10.1038/nature10744 · Cited by 1,034
Martinez, J., Malireddi, R. K. S., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J.-L., Tan, H., Peng, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3192 · Cited by 758
Retracted
Metadata
- Authors
- Yang, Z., & Klionsky, D. J.
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Volume
- 335
- Pages
- 1-32
- ISSN
- 0070-217X (ISSN-L)
- OpenAlex
- W66711298
- Cited by
- 832
- References
- 20
- FWCI
- 138.34
- Type
- book chapter
- Language
- en
- Open access
- green
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