The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An Overview of the Molecular Mechanism of Autophagy
Open accessAbstract
Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle, an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome, for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.
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Citations
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Background
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Metadata
- Authors
- Yang, Z., & Klionsky, D. J.
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Volume
- 335
- Pages
- 1-32
- ISSN
- 0070-217X (ISSN-L)
- OpenAlex
- W66711298
- Cited by
- 832
- References
- 20
- FWCI
- 138.34
- Type
- book chapter
- Language
- en
- Open access
- green
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