Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739

Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

Galiè, N., Ghofrani, H. A., Torbicki, A., Barst, R. J., Rubin, L. J., Badesch, D. B., Fleming, T. R., Parpia, T., Burgess, G., Branzi, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050010 · Cited by 2,466

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

McLaughlin, V. V., Archer, S. L., Badesch, D. B., Barst, R. J., Farber, H. W., Lindner, J. R., Mathier, M. A., McGoon, M. D., Park, M., Rosenson, R. S., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.01.004 · Cited by 2,359

Pulmonary Arterial Hypertension in France

Humbert, M. J. C., Sitbon, O., Chaouat, A., Bertocchi, M., Habib, G., Gressin, V., Yaïci, A., Weitzenblum, E., Cordier, J.-F., Chabot, F., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200510-1668oc · Cited by 1,994

Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541

Targeting vascular (endothelial) dysfunction

Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501

Inflammation in sickle cell disease

Conran, N., & Belcher, J. D. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189012 · Cited by 316

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 274

Regulation of obesity and insulin resistance by nitric oxide

Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274

Hypertension and physical exercise: The role of oxidative stress

Larsen, M. K., & Matchkov, V. V. (2016) · Medicina · doi:10.1016/j.medici.2016.01.005 · Cited by 236

Soluble GC stimulators and activators: Past, present and future

Sandner, P., Follmann, M., Becker‐Pelster, E., Hahn, M. G., Meier, C., Freitas, C., Roessig, L., & Stasch, J. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15698 · Cited by 107

Mechanisms underlying blood pressure reduction by dietary inorganic nitrate

Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 87

Effects of Endurance and Endurance–Strength Training on Endothelial Function in Women with Obesity: A Randomized Trial

Ratajczak, M., Skrypnik, D., Bogdański, P., Mądry, E., Walkowiak, J., Szulińska, M., Maciaszek, J., Kręgielska-Narożna, M., & Karolkiewicz, J. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16214291 · Cited by 66

Identification of mRNA-miRNA crosstalk in human endothelial cells after exposure of PM2.5 through integrative transcriptome analysis

Wāng, Y., Zou, L., Wu, T., Xiong, L., Zhang, T., Kong, L., Xue, Y., & Tang, M. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.114 · Cited by 61

A review of melatonin in hepatic ischemia/reperfusion injury and clinical liver disease

Li, Y., Yang, Y., Feng, Y., Yan, J., Fan, C., Jiang, S., & Qu, Y. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.934275 · Cited by 54

Down-regulation of AMPK/PPARδ signalling promotes endoplasmic reticulum stress-induced endothelial dysfunction in adult rat offspring exposed to maternal diabetes

Luo, H., Lan, C., Fan, C., Gong, X., Chen, C., Yu, C., Wang, J., Luo, X., Hu, C., José, P. A., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab280 · Cited by 45

ACE2 and the Homolog Collectrin in the Modulation of Nitric Oxide and Oxidative Stress in Blood Pressure Homeostasis and Vascular Injury

Yang, G., Chu, P., Rump, L. C., Le, T. H., & Stegbauer, J. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6950 · Cited by 43

Nitric Oxide Donors as Potential Drugs for the Treatment of Vascular Diseases Due to Endothelium Dysfunction

Paulo, M., Costa, D. E. F. D. R., Bonaventura, D., Lunardi, C. N., & Bendhack, L. M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200519114442 · Cited by 41

Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite

Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35

Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicity

Manucha, W. A. (2016) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.04.002 · Cited by 34

Antiobesogenic Role of Endothelial Nitric Oxide Synthase

Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 26

Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs

Zhang, H., Zhao, J., Yu, H., & Guo, D. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.01.011 · Cited by 25

Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress

Chen, X., Qi, L., Fan, X., Tao, H., Zhang, M., Gao, Q., Liu, Y., Xu, T., Zhang, P., Su, H., et al. (2019) · Hypertension Research · doi:10.1038/s41440-018-0181-7 · Cited by 23

Novel investigational therapies for treating pulmonary arterial hypertension

Sardana, M., Moll, M. R., & Farber, H. W. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1098616 · Cited by 13

Cullin 5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

Wang, L., Huang, J., Zhang, R., Zhang, M., Guo, Y., Yang, L., Li, C., Wang, W., Ying, S., Liu, J., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108199 · Cited by 12

Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases

Lv, S., Feng, Y., Jiang, Q., Lv, X., & Yang, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8866725 · Cited by 11

Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition

Ramprasath, T., Freddy, A. J., Velmurugan, G., Tomar, D., Balakrishnan, R., Suvekbala, V., & Ramasamy, S. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666200130094512 · Cited by 10

Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome

Soto, M. E., Pérez-Torres, I., Manzano-Pech, L., Soria‐Castro, E., Morales-Marín, A., Ramírez-Marroquín, E. S., Martínez-Hernández, H., Herrera-Alarcón, V., & Guarner‐Lans, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310429 · Cited by 9

Vascular Health Triad in Humans With Hypertension—Not the Usual Suspects

Ranadive, S. M., Dillon, G. A., Mascone, S. E., & Alexander, L. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746278 · Cited by 9

Gene expression profiling of common signal transduction pathways affected by rBMSCs/F92A-Cav1 in the lungs of rat with pulmonary arterial hypertension

Chen, H., Yang, H., Xu, C. B., Yue, H., Xia, P., Strappe, P., Wang, L., Li, P., Tang, W., Chen, S., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.028 · Cited by 6

Decrease of MYPT1 Is Critical for Impairment of NO-mediated Vasodilation in Mesenteric Artery of the Older Spontaneously Hypertensive Rats

Cui, Y., Yang, L., Liu, X., Che, C., Cheng, J., Li, P., Wen, J., & Yang, Y. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab290 · Cited by 3

Endothelial Alterations in Aging

Wajngarten, M., Nussbacher, A., Dourado, P. M. M., & Chagas, A. C. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812348-5.00018-0 · Cited by 2

Nitric Oxide Pathways in Neurotoxicity from Glutamate-Induced Apoptosis: Emerging Mitochondrial Role

Manucha, W. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-53126-7_12 · Cited by 1

The anti-obesogenic effects of nitric oxide.

Sansbury, B. E. (2014) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1262

Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicity

Manucha, W. A. (2017) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.03.003

Soluble guanylate cyclase stimulators and activators: Chemistry, biology, and therapeutic advances

Zuo, Z., Yang, H., Feng, Q., Ran, J., & Chen, M. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119257

Endothelial Redox Dysregulation in Pulmonary Arterial Hypertension: Compartmentalized Mechanisms and Therapeutic Implications

Moreno-Caceres, S., & Marciano, D. P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209096

Reactive oxygen and nitrogen species in pulmonary hypertension

Tabima, D. M., Frizzell, S. A., & Gladwin, M. T. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.041 · Cited by 194

Redox Regulation of Lung Endothelial Perk, Unfolded Protein Response (Upr) and Proliferation Via Nox1: Targeted Inhibition as a Potential Therapy for PahPreprint

Goossen, C., Kufner, A., Dustin, C. M., Ghouleh, I. A., Yuan, S. S., Straub, A. C., Sembrat, J., Baust, J., Gomez, D. A., Kračun, D., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5064708

Oxidative and nitrosative signalling in pulmonary arterial hypertension — Implications for development of novel therapies

Hansen, T., Galougahi, K. K., Celermajer, D. S., Rasko, N. B., Tang, O., Bubb, K. J., & Figtree, G. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.05.005 · Cited by 48

Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil

Başarıcı, İ., Özen, N., Kilavuz, E., Kısak, F., Basralı, F., Yaraş, N., Köksoy, S., Çelik, M. L., & Ülker, P. (2020) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-200892 · Cited by 10