Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

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Vascular endothelial cells synthesize nitric oxide from L-arginine

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The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

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Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

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ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

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Pulmonary Arterial Hypertension in France

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Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

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Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

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Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

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The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin

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The cellular production of hydrogen peroxide

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Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

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Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

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Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease

Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035477 · Cited by 1,325

Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension

Sitbon, O., Humbert, M. J. C., Jaïs, X., Ioos, V., Hamid, A. M., Provencher, S., Garcia, G., Parent, F., Hervé, P., & Simonneau, G. (2005) · Circulation · doi:10.1161/circulationaha.104.488486 · Cited by 1,244

An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension

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ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

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Tadalafil Therapy for Pulmonary Arterial Hypertension

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Hyperglycemic Pseudohypoxia and Diabetic Complications

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Diagnosis and differential assessment of pulmonary arterial hypertension

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Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913

Molecular pathogenesis of pulmonary arterial hypertension

Rabinovitch, M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33452 · Cited by 881

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

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Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

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The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

Vignais, P. V. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8520-9 · Cited by 799

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

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Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension, and Mortality in Sickle Cell Disease

Morris, C. R. (2005) · JAMA · doi:10.1001/jama.294.1.81 · Cited by 769

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

Ghofrani, H. A., Wiedemann, R., Rose, F., SCHERMULY, R. T., Olschewski, H., Weißmann, N., Günther, A., WALMRATH, D., Seeger, W., & Grimminger, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11024-5 · Cited by 766

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

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Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function

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Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

Hassoun, P. M., Mouthon, L., Barberà, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Maitland, M. L., Michelakis, E. D., Morrell, N. W., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.006 · Cited by 711

Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

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Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

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Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

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A Controlled Trial of Sildenafil in Advanced Idiopathic Pulmonary Fibrosis

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Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

Gaston, B. M., Reilly, J., Drazen, J. M., Fackler, J. C., Ramdev, P., Arnelle, D. R., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10957 · Cited by 620

Nitrate and nitrite in biology, nutrition and therapeutics

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Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

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S-nitrosylation in health and disease

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NO-independent regulatory site on soluble guanylate cyclase

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Essential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock

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A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease

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Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase

Friebe, A., & Koesling, D. (2003) · Circulation Research · doi:10.1161/01.res.0000082524.34487.31 · Cited by 508

Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide

Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 495

The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems

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Pulmonary Complications of Sickle Cell Disease

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Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

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Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

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Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

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Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin

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The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)

Voskaridou, E., Christoulas, D., Bilalis, A., Plata, E., Varvagiannis, K., Stamatopoulos, G., Sinopoulou, K., Balassopoulou, A., Loukopoulos, D., & Terpos, E. (2010) · Blood · doi:10.1182/blood-2009-05-221333 · Cited by 430

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

Archer, S. L., Marsboom, G., Kim, G. H., Zhang, H. J., Tóth, P. T., Svensson, E. C., Dyck, J. R. B., Gomberg‐Maitland, M., Thébaud, B., Husain, A. N., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.916098 · Cited by 410

Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

Sturrock, A., Cahill, B., Norman, K., Huecksteadt, T. P., Hill, K., Sanders, K., Karwande, S. V., Stringham, J. C., Bull, D. A., Gleich, M., et al. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00269.2005 · Cited by 402

Hydrogen peroxide is the major oxidant product of xanthine oxidase

Kelley, E. E., Khoo, N. K. H., Hundley, N. J., Malik, U. Z., Freeman, B. Α., & Tarpey, M. M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.012 · Cited by 399

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

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Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension

de Man, F. S., Tu, L., Handoko, M. L., Rain, S., Ruiter, G., François, C., Schalij, I., Dorfmüller, P., Simonneau, G., Fadel, E., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0411oc · Cited by 346

Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation

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The Toxicology of Inhaled Nitric Oxide

Weinberger, B. I. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.5 · Cited by 343

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin

Minneci, P. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25040 · Cited by 336

Nitric Oxide and Mitochondrial Signaling: From Physiology to Pathophysiology

Erusalimsky, J. D., & Moncada, S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.151167 · Cited by 336

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

Mittal, M., Roth, M., König, P., Hofmann, S., Dony, E., Goyal, P., Selbitz, A.-C., SCHERMULY, R. T., Ghofrani, H. A., Kwapiszewska, G., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.148015 · Cited by 328

Arginine Therapy

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Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2

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Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

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Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

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Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension

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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

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Pulmonary hypertension in patients with sickle cell disease: a longitudinal study

Ataga, K. I., Moore, C. G., Jones, S., Olajide, O., Strayhorn, D., Hinderliter, A., & Orringer, E. P. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06110.x · Cited by 298

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112761 · Cited by 298

Impaired nitric oxide bioavailability and l -arginine–reversible endothelial dysfunction in adults with falciparum malaria

Yeo, T. W., Lampah, D. A., Gitawati, R., Tjitra, E., Kenangalem, E., McNeil, Y., Darcy, C. J., Granger, D. L., Weinberg, J. B., Lopansri, B. K., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070819 · Cited by 297

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth

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Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

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Human neuroglobin functions as a redox-regulated nitrite reductase

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Nitrite Reductase Function of Deoxymyoglobin: Oxygen Sensor and Regulator of Cardiac Energetics and Function

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