Folding Efficiency Is Rate-limiting in Dopamine D4 Receptor Biogenesis
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Dopamine receptors are G protein-coupled receptors that are critically involved in locomotion, reward, and cognitive processes. The D2 class of dopamine receptors (DRD2, -3, and -4) is the target for antipsychotic medication. DRD4 has been implicated in cognition, and genetic studies have found an association between a highly polymorphic repeat sequence in the human DRD4 coding region and attention deficit hyperactivity disorder. Using DRD4 as a model, we show that antipsychotics can function as potent pharmacological chaperones up-regulating receptor expression and can also rescue a non-functional DRD4 folding mutant. This chaperone-mediated up-regulation involves reduced degradation by the 26 S proteasome; likely via the stabilization of newly synthesized receptor in the endoplasmic reticulum. Dopamine itself can function as a chaperone when shuttled into the cell by means of the dopamine transporter. Furthermore, different repeat variants of DRD4 display differential sensitivity to this chaperone effect. These data suggest that folding efficiency may be rate-limiting for dopamine receptor biogenesis and that this efficiency differs between receptor variants. Consequently, the clinical profile of dopaminergic ligands, including antipsychotics, may include their ability to serve as pharmacological chaperones.
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Functional significance of the DRD4 48-bp exon III VNTR polymorphism has been demonstrated.
“Functional significance of this polymorphism has been demonstrated [70–75].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [74]
The 7 R DRD4 allele reduces in-vitro DRD4 expression and is less likely to form heterodimers with the dopamine D2 receptor, while the 4 R allele appears less responsive to quinpirole-mediated DRD4 upregulation.
“The 7 R has been shown to reduce in-vitro DRD4 expression [73] and to be less likely to form heterodimers with the dopamine D2 receptor [76], while the 4 R allele appears to be less responsive to quinpirole-mediated DRD4 upregulation [74].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [74]
Cites
Quality control in the endoplasmic reticulum
Ellgaard, L., & Helenius, A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1052 · Cited by 2,130 · see citing works
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
Schubert, U., Antón, L. C., Gibbs, J. S., Norbury, C. C., Yewdell, J. W., & Bennink, J. R. (2000) · Nature · doi:10.1038/35008096 · Cited by 1,536 · see citing works
Unfolding the role of protein misfolding in neurodegenerative diseases
Soto, C. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1007 · Cited by 1,506 · see citing works
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475 · see citing works
Setting the Standards: Quality Control in the Secretory Pathway
Ellgaard, L., Molinari, M., & Helenius, A. (1999) · Science · doi:10.1126/science.286.5446.1882 · Cited by 1,192 · see citing works
Benjamin, J., Li, L., Patterson, C. A., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996) · Nature Genetics · doi:10.1038/ng0196-81 · Cited by 1,191 · see citing works
Multiple dopamine D4 receptor variants in the human population
Tol, H. H. M. V., Wu, C. M., Guan, H.-C., Ohara, K., Bunzow, J. R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H. B., & Jovanovic, V. (1992) · Nature · doi:10.1038/358149a0 · Cited by 955 · see citing works
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858 · see citing works
Faraone, S., Doyle, A., Mick, E., & Biederman, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1052 · Cited by 740 · see citing works
Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.
LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C. G., Wigal, T. L., King, N., & Kennedy, J. L. (1996) · PubMed · Cited by 678 · see citing works
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol
Tsai, B., Ye, Y., & Rapoport, T. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm780 · Cited by 647 · see citing works
Dopamine D4 receptors elevated in schizophrenia
Seeman, P. M., Guan, H., & Tol, H. H. M. V. (1993) · Nature · doi:10.1038/365441a0 · Cited by 627 · see citing works
Morello, J.-P., Salahpour, A., Laperrière, A., Bernier, V., Arthus, M., Lonergan, M., Petäjä‐Repo, U. E., Angers, S., Morin, D., Bichet, D. G., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8688 · Cited by 558 · see citing works
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Lichter, J. B., Barr, C. L., Kennedy, J. L., Tol, H. H. M. V., Kídd, K. K., & Livak, K. J. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.6.767 · Cited by 524 · see citing works
Glycerol Reverses the Misfolding Phenotype of the Most Common Cystic Fibrosis Mutation
Sato, S., Ward, C. L., Krouse, M. E., Wine, J. J., & Kopito, R. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.635 · Cited by 519 · see citing works
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506 · see citing works
ER-associated degradation in protein quality control and cellular regulation
Hampton, R. Y. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00358-7 · Cited by 475 · see citing works
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
Chang, F., Kídd, K. K., Livak, K. J., PAKSTIS, A. J., & Kídd, K. K. (1996) · Human Genetics · doi:10.1007/s004390050166 · Cited by 438 · see citing works
NMDA receptor-mediated control of protein synthesis at developing synapses
Scheetz, A., Nairn, A., & Constantine-Paton, M. (2000) · Nature Neuroscience · doi:10.1038/72915 · Cited by 382 · see citing works
Bimodal Distribution of Dopamine Receptor Densities in Brains of Schizophrenics
Seeman, P. M., Ulpian, C., Bergeron, C., Riederer, P. F., Jellinger, K. A., Gabriel, E., Reynolds, G. P., & Tourtellotte, W. W. (1984) · Science · doi:10.1126/science.6147018 · Cited by 348 · see citing works
A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
Sommer, T., & Jentsch, S. (1993) · Nature · doi:10.1038/365176a0 · Cited by 334 · see citing works
Tamarappoo, B. K., & Verkman, A. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2303 · Cited by 330 · see citing works
Schizophrenia: More dopamine, more D <sub>2</sub> receptors
Seeman, P., & Kapur, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7673 · Cited by 279 · see citing works
Swanson, J., Oosterlaan, J., Murias, M., Schuck, S., Flodman, P., Spence, M. A., Wasdell, M., Ding, Y., Chi, H.-C., Smith, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080070897 · Cited by 267 · see citing works
Petäjä‐Repo, U. E., Hogue, M., Bhalla, S. S., Laperrière, A., Morello, J.-P., & Bouvier, M. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1628 · Cited by 262 · see citing works
Pharmacological chaperones: a new twist on receptor folding
Morello, J.-P., Bouvier, M., Petäjä‐Repo, U. E., & Bichet, D. G. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01575-3 · Cited by 240 · see citing works
Kotecha, S. A., Oak, J. N., Jackson, M. F., Perez, Y., Orser, B. A., Tol, H. H. M. V., & MacDonald, J. F. (2002) · Neuron · doi:10.1016/s0896-6273(02)00859-0 · Cited by 227 · see citing works
Self-citationCorrection of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators
Loo, T. W., & Clarke, D. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.709 · Cited by 223 · see citing works
Dendrodendritic Inhibition Through Reversal of Dopamine Transport
Falkenburger, B. H., Barstow, K. L., & Mintz, I. M. (2001) · Science · doi:10.1126/science.1060645 · Cited by 214 · see citing works
The human dopamine D4 receptor repeat sequences modulate expression
Schoots, O., & Van Tol, H. H. M. (2003) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500208 · Cited by 213 · see citing works
Lavine, N. E., Éthier, N., Oak, J. N., Pei, L., Liu, F., Trieu, P., Rebois, R. V., Bouvier, M., Hébert, T. E., & Tol, H. H. M. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205035200 · Cited by 201 · see citing works
Self-citationNoorwez, S. M., Kuksa, V., Imanishi, Y., Zhu, L. H., Filipek, S., Palczewski, K., & Kaushal, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300087200 · Cited by 200 · see citing works
Segman, R. H., Neeman, T., Heresco‐Levy, U., Finkel, B., Karagichev, L., Schlafman, M., Dorevitch, A., Yakir, A., Lerner, A., Shelevoy, A., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000511 · Cited by 153 · see citing works
Pristupa, Z. B., Wilson, J. M., Hoffman, B. J., Kish, S. J., & Niznik, H. B. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09894-3 · Cited by 153 · see citing works
Oak, J. N., Lavine, N. E., & Tol, H. H. M. V. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.92 · Cited by 130 · see citing works
Self-citationSH3 Binding Domains in the Dopamine D4 Receptor
Oldenhof, J., Vickery, R. G., Anafi, M., Oak, J. N., Ray, A. P., Schoots, O., Pawson, T. J., von Zastrow, M., & Tol, H. H. M. V. (1998) · Biochemistry · doi:10.1021/bi981634+ · Cited by 100 · see citing works
Self-citationLack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level
Tol, H. H. M. V., Riva, M. A., Civelli, O., & Creese, I. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90279-i · Cited by 94 · see citing works
Halaban, R., Cheng, E., Svedine, S., Aron, R., & Hebert, D. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008703200 · Cited by 90 · see citing works
Striatal dopamine D2 receptors in tardive dyskinesia: PET study.
Blin, J., Baron, J., Cambon, H., Bonnet, A. M., Dubois, B., Loc’h, C., Maziere, B., & Agid, Y. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.11.1248 · Cited by 79 · see citing works
Intracellular Surveillance: Controlling the Assembly of MHC Class I‐Peptide Complexes
Cresswell, P. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010402.x · Cited by 78 · see citing works
Attaix, D., Combaret, L., Pouch-Pélissier, M.-N., & Taillandier, D. (2001) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200101000-00009 · Cited by 74 · see citing works
The dopamine D4 receptors and mechanisms of antipsychotic atypicality.
Wong, A., & van Tol, H. V. (2003) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.005 · Cited by 72 · see citing works
Turrone, P., Remington, G. J., Kapur, S., & Nóbrega, J. N. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1259-z · Cited by 63 · see citing works
Damask, S. P., Bovenkerk, K. A., de la Pena, G., Hoversten, K. M., Peters, D. B., Valentine, A. M., & Meador‐Woodruff, J. H. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00101-5 · Cited by 59 · see citing works
Intracellular mislocalization of mutant podocin and correction by chemical chaperones
Ohashi, T., Uchida, K., Uchida, S., Sasaki, S., & Nihei, H. (2003) · Histochemistry and Cell Biology · doi:10.1007/s00418-003-0511-x · Cited by 57 · see citing works
Effect of haloperidol on expression of dopamine D2 receptor mRNAs in rat brain
Srivastava, L. K., Morency, M. A., Bajwa, S. B., & Mishra, R. K. (1990) · Journal of Molecular Neuroscience · doi:10.1007/bf02896840 · Cited by 48 · see citing works
The Effects of Haloperidol on Dopamine Receptor Gene Expression
Fox, C. A., Mansour, A., & Watson, S. J. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1207 · Cited by 44 · see citing works
Paradoxical regulation of dopamine receptors in transfected 293 cells.
Filtz, T. M., Artymyshyn, R. P., Guan, W., & Molinoff, P. B. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13181-7 · Cited by 40 · see citing works
Filtz, T. M., Guan, W., Artymyshyn, R. P., Facheco, M., Ford, C., & Molinoff, P. B. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24044-7 · Cited by 37 · see citing works
Ligand-dependent secretion of rat retinol-binding protein expressed in HeLa cells.
Melhus, H., Laurent, B., Rask, L., & Peterson, P. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49802-5 · Cited by 22 · see citing works
Qian, Y., Hitzemann, B. A., Yount, G. L., White, J. D., & Hitzemann, R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39455-3 · Cited by 14 · see citing works
See, R. E., Lynch, A. M., & Sorg, B. A. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00540-4 · Cited by 7 · see citing works
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Tao, Y.-X. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0037 · Cited by 531 · see citing works
The molecular genetic architecture of human personality: beyond self-report questionnaires
Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001814 · Cited by 362 · see citing works
Eisenberg, D. T. A., MacKillop, J., Modi, M. E., Beauchemin, J., Dang, D., Lisman, S. A., Lum, J. K., & Wilson, D. S. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-2 · Cited by 257 · see citing works
Marinko, J. T., Huang, H., Penn, W. D., Capra, J. A., Schlebach, J. P., & Sanders, C. R. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00532 · Cited by 249 · see citing works
Eisenberg, D. T. A., Campbell, B., Gray, P. B., & Sorenson, M. D. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-173 · Cited by 197 · see citing works
Exercise impact on sustained attention of ADHD children, methylphenidate effects
Medina, J. A., Netto, T. L. B., Muszkat, M., Medina, A. C., Botter, D. A., Orbetelli, R., Scaramuzza, L. F. C., Sinnes, E. G., Vilela, M., & Miranda, M. C. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-009-0018-y · Cited by 155 · see citing works
Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics
Tao, Y., & Conn, P. M. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1121 · Cited by 146 · see citing works
The dopamine D4 receptor: biochemical and signalling properties
Rondou, P., Haegeman, G., & Craenenbroeck, K. V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0293-y · Cited by 132 · see citing works
Ben-Zion, I., Tessler, R. J., Cohen, L., Lerer, E., Raz, Y., Bachner‐Melman, R., Gritsenko, I., Nemanov, L., Zohar, A. H., Belmaker, R. H., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001832 · Cited by 117 · see citing works
Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases
Tao, Y., & Conn, P. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00029.2016 · Cited by 115 · see citing works
Gervai, J., Novák, A., Lakatos, K., Tóth, I., Danis, I., Rónai, Z., Nemoda, Z., Sasvári‐Székely, M., Bureau, J.-F., Bronfman, E. T., et al. (2007) · Social Neuroscience · doi:10.1080/17470910701391893 · Cited by 108 · see citing works
Chemical and pharmacological chaperones as new therapeutic agents
Loo, T. W., & Clarke, D. M. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000361 · Cited by 102 · see citing works
Chapter 6 Mutations in Melanocortin‐4 Receptor and Human Obesity
Tao, Y. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)88006-x · Cited by 101 · see citing works
Pharmacological chaperoning: A primer on mechanism and pharmacology
Leidenheimer, N. J., & Ryder, K. G. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.01.005 · Cited by 102 · see citing works
Fan, Z., & Tao, Y. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00726.x · Cited by 98 · see citing works
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Vidi, P., Chemel, B. R., Hu, C., & Watts, V. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.047472 · Cited by 91 · see citing works
A neurochemical approach to valuation sensitivity over gains and losses
Zhong, S., Israel, S., Xue, H., Sham, P. C., Ebstein, R. P., & Chew, S. H. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.1312 · Cited by 91 · see citing works
MacKillop, J. M., Menges, D., McGeary, J. E., & Lisman, S. A. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-11 · Cited by 88 · see citing works
Free, R. B., Hazelwood, L. A., Cabrera, D. M., Spalding, H. N., Namkung, Y., Rankin, M. L., & Sibley, D. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701555200 · Cited by 84 · see citing works
Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype
Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.02.005 · Cited by 82 · see citing works
BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase
Rondou, P., Haegeman, G., Vanhoenacker, P., & Craenenbroeck, K. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708473200 · Cited by 80 · see citing works
Eisenberg, D. T. A., Campbell, B., MacKillop, J., Lum, J., & Wilson, D. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001216 · Cited by 89 · see citing works
Dopaminergic system genes in childhood aggression: Possible role for DRD2
Zai, C. C., Ehtesham, S., Choi, E., Nowrouzi, B., de Luca, V., Stankovich, L., Davidge, K., Freeman, N., King, N., Kennedy, J. L., et al. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.543431 · Cited by 78 · see citing works
Gender-specific expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking
Dmitrieva, J., Chen, C., Greenberger, E., Ogunseitan, O. A., & Ding, Y.-C. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq020 · Cited by 78 · see citing works
Adenosine receptor desensitization and trafficking
Mundell, S. J., & Kelly, E. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.007 · Cited by 75 · see citing works
Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4)
Bachner‐Melman, R., Lerer, E., Zohar, A. H., Kremer, I., Elizur, Y., Nemanov, L., Golan, M., Blank, S., Gritsenko, I., & Ebstein, R. P. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30505 · Cited by 73 · see citing works
Parenting and Child DRD4 Genotype Interact to Predict Children’s Early Emerging Effortful Control
Smith, H. J., Sheikh, H. I., Dyson, M. W., Olino, T. M., Laptook, R. S., Durbin, C. E., Hayden, E. P., Singh, S. M., & Klein, D. N. (2012) · Child Development · doi:10.1111/j.1467-8624.2012.01818.x · Cited by 73 · see citing works
Leskelaö, T. T., Markkanen, P. M. H., Pietilaö, E. M., Tuusa, J. T., & Petäjä‐Repo, U. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610896200 · Cited by 72 · see citing works
Dopamine D4 Receptor Gene Associated with Fairness Preference in Ultimatum Game
Zhong, S., Israel, S., Shalev, I., Xue, H., Ebstein, R. P., & Chew, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013765 · Cited by 67 · see citing works
Butovskaya, M., Vasilyev, V. A., Lazebny, O. E., Burkova, V. N., Куликов, А. М., Mabulla, A. Z. P., Shibalev, D. V., & Рысков, А. П. (2012) · Behavior Genetics · doi:10.1007/s10519-012-9533-2 · Cited by 65 · see citing works
Role of glucocorticoids in dopamine-related neuropsychiatric disorders
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The role of parenting and dopamine D4 receptor gene polymorphisms in children's inhibitory control
Smith, H. J., Kryski, K. R., Sheikh, H. I., Singh, S. M., & Hayden, E. P. (2013) · Developmental Science · doi:10.1111/desc.12046 · Cited by 60 · see citing works
Tropak, M. B., & Mahuran, D. J. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06040.x · Cited by 60 · see citing works
Environmental and genetic influences on early attachment
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Regulation of G Protein-Coupled Receptors by Ubiquitination
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Quality control for unfolded proteins at the plasma membrane
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Rescue of Folding Defects in ABC Transporters Using Pharmacological Chaperones
Loo, T. W., Bartlett, M. C., & Clarke, D. M. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-9499-3 · Cited by 55 · see citing works
Wilson, S. J., Cavanagh, C. C., Lesher, A. M., Frey, A. J., Russell, S. E., & Smyth, E. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800447-jlr200 · Cited by 54 · see citing works
Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects
Lester, H. A., Miwa, J. M., & Srinivasan, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.020 · Cited by 53 · see citing works
Eshaq, R. S., Stahl, L. D., Stone, R., Smith, S. S., Robinson, L. C., & Leidenheimer, N. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.030 · Cited by 47 · see citing works
The VNTR in complex disorders: The forgotten polymorphisms? A functional way forward?
Brookes, K. J. (2013) · Genomics · doi:10.1016/j.ygeno.2013.03.003 · Cited by 47 · see citing works
Kurosawa, S., Hashimoto, E., Ukai, W., Toki, S., Saitô, S., & Saito, T. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0747-z · Cited by 46 · see citing works
Chen, Y., Chen, C., Wang, Y., & Liu‐Chen, L. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107987 · Cited by 44 · see citing works
Beerepoot, P., Nazari, R., & Salahpour, A. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.036 · Cited by 39 · see citing works
Pharmacochaperoning of the A1 Adenosine Receptor Is Contingent on the Endoplasmic Reticulum
Málaga-Diéguez, L., Yang, Q., Bauer, J., Pankevych, H., Freissmuth, M., & Nanoff, C. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.063511 · Cited by 39 · see citing works
Hwang, R., Tiwari, A. K., Zai, C. C. H., Felsky, D., Remington, E., Wallace, T., Tong, R. P., de Souza, R. P., Oh, G., Potkin, S. G., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.018 · Cited by 38 · see citing works
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Dopamine D<sub>4</sub> receptor oligomerization – contribution to receptor biogenesis
Van Craenenbroeck, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Skieterska, K., Rondou, P., Lintermans, B., Vanhoenacker, P., Fuxe, K., Ciruela, F., & Haegeman, G. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08052.x · Cited by 33 · see citing works
A Nonpeptide Antagonist Reveals a Highly Glycosylated State of the Rabbit Kinin B1 Receptor
Fortin, J., Dziadulewicz, E. K., Gera, L., & Marceau, F. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019976 · Cited by 33 · see citing works
Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation
Spooren, A., Rondou, P., Debowska, K., Lintermans, B., Vermeulen, L., Samyn, B., Skieterska, K., Debyser, G., Devreese, B. V., Vanhoenacker, P., et al. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.013 · Cited by 32 · see citing works
Pappa, I., Mileva‐Seitz, V. R., Bakermans‐Kranenburg, M. J., Tiemeier, H. W., & van IJzendoorn, M. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.009 · Cited by 31 · see citing works
Rondou, P., Skieterska, K., Packeu, A., Lintermans, B., Vanhoenacker, P., Vauquelin, G., Haegeman, G., & Craenenbroeck, K. V. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.014 · Cited by 31 · see citing works
Qian, M., Vasudevan, L., Huysentruyt, J., Risseeuw, M., Stove, C. P., Vanderheyden, P., Craenenbroeck, K. V., & Calenbergh, S. V. (2018) · ChemMedChem · doi:10.1002/cmdc.201700787 · Cited by 30 · see citing works
The role of D4 receptor gene exon III polymorphisms in shaping human altruism and prosocial behavior
Jiang, Y., Chew, S. H., & Ebstein, R. P. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00195 · Cited by 29 · see citing works
Polymorphisms in the Dopamine D4 and D2 Receptor Genes and Reproductive and Sexual Behaviors
Eisenberg, D. T. A., Campbell, B., MacKillop, J. M., Modi, M. E., Dang, D. T., Lum, J. K., & Wilson, D. S. (2007) · Evolutionary Psychology · doi:10.1177/147470490700500402 · Cited by 29 · see citing works
Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function
Clark, S. D., Tran, H. T. T., Zeng, J., & Reinscheid, R. K. (2009) · Peptides · doi:10.1016/j.peptides.2009.10.015 · Cited by 28 · see citing works
Self-citationDopamine receptor (D4) polymorphism is related to comorbidity between marijuana abuse and depression
Bobadilla, L., Vaske, J. C., & Asberg, K. K. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.05.014 · Cited by 28 · see citing works
Czermak, C., Lehofer, M., Liebmann, P. M., & Traynor, J. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.11.063 · Cited by 27 · see citing works
Detection of G Protein-Coupled Receptor (GPCR) Dimerization by Coimmunoprecipitation
Skieterska, K., Duchou, J., Lintermans, B., & Craenenbroeck, K. V. (2013) · Methods in cell biology · doi:10.1016/b978-0-12-408143-7.00017-7 · Cited by 26 · see citing works
Chapter 5 Follicle Stimulating Hormone Receptor Mutations and Reproductive Disorders
Tao, Y., & Segaloff, D. L. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)89005-4 · Cited by 23 · see citing works
Sahlholm, K., Marcellino, D. J., Nilsson, J., Ögren, S. O., Fuxé, K., & Århem, P. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000801 · Cited by 23 · see citing works
eWang, P., Eshaq, R. S., Meshul, C. K., Moore, C., Hood, R. L., & Leidenheimer, N. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00188 · Cited by 21 · see citing works
Hakalahti, A. E., Khan, H., Vierimaa, M. M., Pekkala, E. H., Lackman, J. J., Ulvila, J., Kerkelä, R., & Petäjä‐Repo, U. E. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080440 · Cited by 21 · see citing works
Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin
Deming, J. D., Shin, J., Lim, K., Lee, E.-J., Craenenbroeck, K. V., & Craft, C. M. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.008 · Cited by 20 · see citing works
GPCR Oligomerization: Contribution to Receptor Biogenesis
Van Craenenbroeck, K. (2012) · Subcellular Biochemistry · doi:10.1007/978-94-007-4765-4_3 · Cited by 18 · see citing works
Regulation of Stability and Trafficking of Calcium-Sensing Receptors by Pharmacologic Chaperones
Huang, Y. S., Cavanaugh, A. H., & Breitwieser, G. E. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00007-5 · Cited by 18 · see citing works
Kusek, J., Yang, Q., Witek, M., Gruber, C. W., Nanoff, C., & Freissmuth, M. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.094045 · Cited by 18 · see citing works
Pharmacological Chaperones: Beyond Conformational Disorders
Leidenheimer, N. J. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_68 · Cited by 18 · see citing works
Targeting opioid receptors with pharmacological chaperones
Petäjä‐Repo, U. E., & Lackman, J. J. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.12.001 · Cited by 17 · see citing works
Newton, C. L., Anderson, R. C., Kreuchwig, A., Krause, G., Katz, A. A., & Millar, R. P. (2020) · Neuroendocrinology · doi:10.1159/000508000 · Cited by 17 · see citing works
Cokan, K. B., Mavri, M., Rutland, C. S., Glišić, S., Senćanski, M., Vrecl, M., & Kubale, V. (2020) · Biomolecules · doi:10.3390/biom10101355 · Cited by 17 · see citing works
Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor
Craenenbroeck, K. V., Gellynck, E., Lintermans, B., Leysen, J. E., Tol, H. H. M. V., Haegeman, G., & Vanhoenacker, P. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.08.024 · Cited by 17 · see citing works
Ananth, M. R., Hetelekides, E. M., Hamilton, J., & Thanos, P. K. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.036 · Cited by 16 · see citing works
Suárez‐Boomgaard, D., Gago, B., Valderrama‐Carvajal, A., Roales‐Buján, R., Craenenbroeck, K. V., Duchou, J., Borroto‐Escuela, D. O., Medina-Luque, J., de la Calle, A., Fuxé, K., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011481 · Cited by 16 · see citing works
Kubale, V., Cokan, K. B., Nøhr, J., Eidne, K. A., & Vrecl, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071152 · Cited by 15 · see citing works
Gill, R. S., Hsiung, M. S., Sum, C. S., Lavine, N. E., Clark, S. D., & Tol, H. H. M. V. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.09.031 · Cited by 15 · see citing works
Self-citationJiang, Y., Bachner‐Melman, R., Chew, S. H., & Ebstein, R. P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00338 · Cited by 15 · see citing works
Yılmaz, Z., Kaplan, A. S., Levitan, R. D., Zai, C. C. H., & Kennedy, J. L. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.20986 · Cited by 14 · see citing works
Eisenberg, D. T. A., Apicella, C. L., Campbell, B., Dreber, A., Garcia, J. R., & Lum, J. K. (2008) · Nature Precedings · doi:10.1093/scan/nsp026 · Cited by 14 · see citing works
DRD4 VNTRs, observed stranger fear in preschoolers and later ADHD symptoms
Pappa, I., Mileva‐Seitz, V. R., Székely, E., Verhulst, F. C., Bakermans‐Kranenburg, M. J., Jaddoe, V. W. V., Albert Hofman, D., Tiemeier, H. W., & van IJzendoorn, M. H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.09.004 · Cited by 13 · see citing works
Pharmacoperones for Misfolded Gonadotropin Receptors
Newton, C. L., & Anderson, R. C. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_64 · Cited by 12 · see citing works
Naumova, D., Grizenko, N., Sengupta, S. M., & Joober, R. (2019) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1410221 · Cited by 14 · see citing works
Janezic, E. M., Lauer, S. M., Williams, R. G., Chungyoun, M., Lee, K.-S., Navaluna, E. D., Lau, H.-T., Ong, S., & Hague, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-64102-4 · Cited by 11 · see citing works
Larsen, S. A., Mogensen, L., Dietz, R., Baagøe, H. J., Andersen, M. L., Werge, T. M., & Rasmussen, H. B. (2005) · DNA and Cell Biology · doi:10.1089/dna.2005.24.795 · Cited by 11 · see citing works
Chaperone-like effects of cell-permeant ligands on opioid receptors
Chen, Y. (2009) · Frontiers in bioscience · doi:10.2741/3269 · Cited by 11 · see citing works
Cao, H., Zhou, N., Leerkes, E. M., & Su, J. (2020) · Journal of Family Psychology · doi:10.1037/fam0000722 · Cited by 9 · see citing works
Gellynck, E., Andressen, K. W., Lintermans, B., Haegeman, G., Levy, F. O., Vanhoenacker, P., & Craenenbroeck, K. V. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08581.x · Cited by 9 · see citing works
Inside job: ligand-receptor pharmacology beneath the plasma membrane
Babcock, J. J., & Li, M. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.51 · Cited by 7 · see citing works
Expression of G‐Protein‐Coupled Receptors
Yeliseev, A., & Vukoti, K. (2011) · Wiley eBooks · doi:10.1002/9783527634521.ch8 · Cited by 7 · see citing works
Ebstein, R. P., & Israel, S. (2009) · Springer eBooks · doi:10.1007/978-0-387-76727-7_17 · Cited by 6 · see citing works
Role of Dimerization in Dopamine D4 Receptor Biogenesis
Craenenbroeck, K. V., Borroto‐Escuela, D. O., Skieterska, K., Duchou, J., Romero‐Fernandez, W., & Fuxé, K. (2014) · Current Protein and Peptide Science · doi:10.2174/1389203715666140901110256 · Cited by 5 · see citing works
Ebstein, R. P., Monakhov, M. V., Lu, Y., Jiang, Y., Lai, P. S., & Chew, S. H. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1360 · Cited by 4 · see citing works
Leidenheimer, N. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00245 · Cited by 4 · see citing works
Chai-Danino, M., Ravensary-Modin, N., Vladimirov, V. I., Onyshchuk, T., Plöhn, M., Barshap, A. B. D., Bsoul, A., Peled‐Zehavi, H., & Fluman, N. (2026) · Nature Communications · doi:10.1038/s41467-026-69829-8 · Cited by 3 · see citing works
The role of genes and abuse in the etiology of offending
Vaske, J. C. (2009) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 3 · see citing works
Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4
Deming, J. D., Craenenbroeck, K. V., Eom, Y. S., Lee, E.-J., & Craft, C. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_88 · Cited by 2 · see citing works
Soukho-Kaya, A., Minta, D. K., Diarra, M. T., Konaté, A., Diallo, B., Sidibé, A., Dembélé, M., De, O., Doumbia, A. K., Dao, K., et al. (2012) · PubMed · Cited by 2 · see citing works
Molecular Genetic Research on Temperament in Infancy and Early Childhood
Sheese, B. E. (2020) · Springer eBooks · doi:10.1007/978-1-0716-0933-0_3 · Cited by 2 · see citing works
Risperidone regulates Dopamine D2-like receptors expression in rat brain in a time-dependent manner
Ni, P., Liang, L., Yingcheng, W., Jinxue, W., Gu, X., Zhao, L., Ma, X., & Li, T. (2015) · The European Journal of Psychiatry · doi:10.4321/s0213-61632015000100003 · Cited by 2 · see citing works
- Authors
- Van Craenenbroeck, K., Clark, S. D., Cox, M. J., Oak, J. N., Liu, F., & Van Tol, H. H. M.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 280
- Issue
- 19
- Pages
- 19350-19357
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2155062549
- Cited by
- 107
- References
- 52
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dopamine D4 receptor, DRD4, receptor biogenesis, pharmacological chaperones, antipsychotic drugs, 26S proteasome degradation, endoplasmic reticulum, dopamine transporter, attention deficit hyperactivity disorder, G protein-coupled receptors, receptor expression
- MeSH terms
- Animals, Cell Line, DNA, Dopamine, Dose-Response Relationship, Drug, Endoplasmic Reticulum, Glycosylation, Cricetinae, Humans, Ligands, Microscopy, Fluorescence, Mutation, Polymorphism, Genetic, Time Factors, Antipsychotic Agents, Transcription, Genetic, Protein Biosynthesis, Blotting, Northern, Blotting, Western, Up-Regulation, CHO Cells, Protein Structure, Tertiary, Receptors, Dopamine D2, Protein Folding, Microscopy, Confocal, Molecular Chaperones, Proteasome Endopeptidase Complex, Receptors, Dopamine D4
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