The effects of scopolamine on working memory in healthy young volunteers

Rusted, J.M.; Warburton, D.M.

doi:10.1007/bf00177553

Cited by 116Cognitive Abilities and TestingSchizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

The effects of scopolamine on working memory in healthy young volunteers

Rusted, J.M., Warburton, D.M.·1988·Psychopharmacology

DOI 10.1007/bf00177553

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Abstract

Twenty healthy young adults completed a series of nonverbal and problem solving tasks in a repeated measures design involving placebo and 0.6 mg scopolamine, administered by subcutaneous injection. Subjects completed the test battery under standard presentation conditions and with concurrent articulation, which precludes verbal recoding of test material. Under standard presentation conditions, scopolamine significantly impaired performance on the problem solving task and on tasks of visuo-spatial and spatial memory; memory for abstract shapes was not impaired. Concurrent articulation impaired performance on the shape recognition and interacted with drug treatment on the problem solving task. The results suggest that scopolamine impairs working memory, and that the decrement is at the level of the central executive mechanisms rather than the subsystems which it controls.

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Authors: Rusted, J. M., & Warburton, D. M.
Affiliations: University of Reading (GB)
ORCID: Rusted, J.M.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1988-10
Volume: 96
Issue: 2
Pages: 145-52
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00177553
OpenAlex: W2074940164
Cited by: 116
References: 21
Citations by year: 2026: 2 · 2025: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 6
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: scopolamine, working memory, central executive, visuospatial memory, spatial memory, problem solving, shape recognition, anticholinergic agents, cognitive impairment
MeSH terms: Adolescent, Adult, Cognition, Humans, Male, Memory, Psychomotor Performance, Scopolamine, Space Perception

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The effects of scopolamine on working memory in healthy young volunteers

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