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Cited by 152Coffee research and impactsCholinesterase and Neurodegenerative DiseasesCognitive Abilities and Testing

Caffeine attenuates scopolamine-induced memory impairment in humans

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Reidel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., Jolles, J.·1995·Psychopharmacology
DOI 10.1007/bf02246090
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Abstract

Caffeine consumption can be beneficial for cognitive functioning. Although caffeine is widely recognized as a mild CNS stimulant drug, the most important consequence of its adenosine antagonism is cholinergic stimulation, which might lead to improvement of higher cognitive functions, particularly memory. In this study, the scopolamine model of amnesia was used to test the cholinergic effects of caffeine, administered as three cups of coffee. Subjects were 16 healthy volunteers who received 250 mg caffeine and 2 mg nicotine separately, in a placebo-controlled double-blind cross-over design. Compared to placebo, nicotine attenuated the scopolamine-induced impairment of storage in short-term memory and attenuated the scopolamine-induced slowing of speed of short-term memory scanning. Nicotine also attenuated the scopolamine-induced slowing of reaction time in a response competition task. Caffeine attenuated the scopolamine-induced impairment of free recall from short- and long-term memory, quality and speed of retrieval from long-term memory in a word learning task, and other cognitive and non-cognitive measures, such as perceptual sensitivity in visual search, reading speed, and rate of finger-tapping. On the basis of these results it was concluded that caffeine possesses cholinergic cognition enhancing properties. Caffeine could be used as a control drug in studies using the scopolamine paradigm and possibly also in other experimental studies of cognitive enhancers, as the effects of a newly developed cognition enhancing drug should at least be superior to the effects of three cups of coffee.

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  • Caffeine is effective in counteracting scopolamine-induced memory impairment in humans and animals.

    “Caffeine, a much more commonly used psychostimulant, was found to be effective in counteracting scopolamine-induced memory impairment in humans and animals [112,113], while no study has been performed to evaluate efficacy of caffeine in the management of MS alone or in combination with scopolamine and antihistamines.”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [113]

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Authors
Reidel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., & Jolles, J.
Affiliations
Maastricht University (NL)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1995-11
Volume
122
Issue
2
Pages
158-168
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02246090
OpenAlex
W2019381424
Cited by
152
References
32
Citations by year
2025: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 16
FWCI
2.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
caffeine, scopolamine, memory impairment, nicotine, cholinergic stimulation, adenosine antagonism, short-term memory, long-term memory, free recall, cognitive enhancement, reaction time, perceptual sensitivity, word learning
MeSH terms
Adult, Central Nervous System Stimulants, Blood Pressure, Caffeine, Chewing Gum, Coffee, Cognition, Double-Blind Method, Female, Humans, Male, Memory Disorders, Nicotine, Psychomotor Performance, Pulse, Scopolamine, Visual Perception, Cross-Over Studies, Nicotinic Agonists, Muscarinic Antagonists

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