Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB
Abstract
Results of a placebo controlled cross-over trial (N = 89) of the anticholinesterase drug THA as a treatment for dementia of the Alzheimer's type (DAT) are reported, with reference to previous trials of the drug and the cholinergic hypothesis of aging and dementia. Using computerised tests sensitive to specific aspects of memory and attention, evidence is found for improvements in attentional function rather than memory, in patients with mild to moderate DAT. Although these improvements were significant, they were small and restricted to certain tests of attentional function. Nevertheless, they add to the growing body of evidence that the cholinergic system is involved in the control of attentional processes. The results will be relevant to future investigations into the therapeutic effects of enhancement of the cholinergic system in DAT sufferers.
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A relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer's disease.
“Moreover, a relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer’s disease (e.g., Sahakian et al, 1993; Foldi et al, 2005).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Sahakian et al, 1993
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- Authors
- Sahakian, B. J., Owen, A. M., Morant, N. J., Eagger, S. A., Boddington, S., Crayton, L., Crockford, H. A., Crooks, M., Hill, K., & Levy, R.
- Affiliations
- University of Cambridge (GB)
- Venue
- Psychopharmacology
- Published
- 1993-03
- Volume
- 110
- Issue
- 4
- Pages
- 395-401
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2056558547
- Cited by
- 226
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- tacrine, Alzheimer's disease, dementia, cholinesterase inhibitors, cholinergic hypothesis, attention, memory, CANTAB, cholinergic system, cognitive function
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Association Learning, Attention, Cognition, Double-Blind Method, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Reaction Time, Space Perception, Tacrine, Cross-Over Studies
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