Cited by 227Dementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB

Sahakian, Barbara J., Owen, Adrian M., Morant, Nicola J., Eagger, Sarah A., Boddington, Stephen, Crayton, Lissa, Crockford, Helena A., Crooks, Maureen +2 more·1993·Psychopharmacology

Abstract

Results of a placebo controlled cross-over trial (N = 89) of the anticholinesterase drug THA as a treatment for dementia of the Alzheimer's type (DAT) are reported, with reference to previous trials of the drug and the cholinergic hypothesis of aging and dementia. Using computerised tests sensitive to specific aspects of memory and attention, evidence is found for improvements in attentional function rather than memory, in patients with mild to moderate DAT. Although these improvements were significant, they were small and restricted to certain tests of attentional function. Nevertheless, they add to the growing body of evidence that the cholinergic system is involved in the control of attentional processes. The results will be relevant to future investigations into the therapeutic effects of enhancement of the cholinergic system in DAT sufferers.

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Crossref · 10.1007/bf02244644

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  • A relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer's disease.

    “Moreover, a relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer’s disease (e.g., Sahakian et al, 1993; Foldi et al, 2005).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Sahakian et al, 1993

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Authors
Sahakian, B. J., Owen, A. M., Morant, N. J., Eagger, S. A., Boddington, S., Crayton, L., Crockford, H. A., Crooks, M., Hill, K., & Levy, R.
Affiliations
University of Cambridge (GB)
Venue
Psychopharmacology
Published
1993-03
Volume
110
Issue
4
Pages
395-401
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2056558547
Cited by
226
References
43
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 5 · 2012: 4
FWCI
10.40
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
tacrine, Alzheimer's disease, dementia, cholinesterase inhibitors, cholinergic hypothesis, attention, memory, CANTAB, cholinergic system, cognitive function
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Association Learning, Attention, Cognition, Double-Blind Method, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Reaction Time, Space Perception, Tacrine, Cross-Over Studies

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