Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390
Abstract
The subtype of dopamine receptor related to the rewarding effect of brain stimulation was determined in 17 rats. The animals were trained to contact a dry spout to receive stimulation through electrodes implanted into the lateral hypothalamic area, ventral tegmental area, or dorsal raphe nucleus. The dopamine D1 blocking agent SCH 23390, 0.08 mg/kg IP, completely suppressed responding. The D2 receptor blocker sulpiride, 50 mg/kg IP, or the serotonin receptor blocker metergoline, 5 mg/kg IP, did not suppress responding. The ED50 for SCH 23390 was 0.022 mg/kg IP. In a runway, rats were trained to run for rewarding goal stimulation consisting of a train of pulses delivered to the lateral hypothalamus. After injection of SCH 23390, 0.01 mg/kg IP, animals showed significantly slower running speed, but their speed returned to normal if the number of pulses in the goal stimulation was increased 2.6 times. These results indicate that blockade of D1 receptors, but not D2 receptors, reduces the rewarding effect of brain stimulation.
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Cocaine primarily activates D1R-containing neurons, which are necessary for reward-related learning and maintenance of reward-related behaviors.
“Cocaine primarily activates D1R-containing neurons, which are necessary for reward-related learning and maintenance of reward-related behaviors (Nakajima 1986; Nakajima and Mckenzie 1986; Beninger et al 1987; Bertran-Gonzalez et al 2008).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Nakajima and Mckenzie 1986
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“Cocaine primarily activates D1R - containing neurons , which are necessary for reward - related learning and main - tenance of reward - related behaviors ( Nakajima 1986 ; Nakajima and Mckenzie 1986 ; Beninger et al .”
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- Authors
- Nakajima, S., & McKenzie, G. M.
- Affiliations
- Dalhousie University (CA)
- Corresponding author
- Nakajima, Shinshu
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1986-04
- Volume
- 24
- Issue
- 4
- Pages
- 919-923
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2041103283
- Cited by
- 81
- References
- 32
- Citations by year
- 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine D1 receptor, brain stimulation reward, SCH 23390, dopamine D2 receptor, sulpiride, serotonin receptor blockade, lateral hypothalamus, ventral tegmental area, dorsal raphe nucleus
- MeSH terms
- Animals, Benzazepines, Brain, Brain Mapping, Haloperidol, Hypothalamic Area, Lateral, Male, Raphe Nuclei, Receptors, Dopamine, Reward, Self Stimulation, Sulpiride, Tegmentum Mesencephali, Rats
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