Cited by 109Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Receptor subtype-specific dopaminergic agents and conditioned behavior

Beninger, Richard J., Hoffman, Diane C., Mazurski, Evalynn J.·1989·Neuroscience & Biobehavioral Reviews

Abstract

Dopaminergic neurotransmission has been implicated in reward-related learning. With the advent of pharmacological agents that are relatively specific for D1 and D2 dopamine receptors, it has become possible to assess the role of these receptor subtypes in this form of learning. Antagonist studies have shown that either D1 or D2 receptor blockers produced extinction-like effects on operant responding for food, water or brain stimulation reward and in drug self-administration paradigms. They also blocked place preference learning based on amphetamine. Agonist studies showed that D2, but not D1 agonists were self-administered, produced place preferences and enhanced responding for conditioned reward. It may be that the dopaminergic signal at the D1 receptor is important for the establishment and maintenance of reward-related learning. From this point of view the effects of D1 antagonists can be understood. D2 antagonists may produce extinction-like effects because they lead to increased dopamine release and, therefore, indirectly mask the dopamine signal at the D1 receptor. D1 agonists may fail to produce reward effects because they, unlike D2 agonists, directly mask the dopaminergic signal at the D1 receptor.

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Crossref · 10.1016/s0149-7634(89)80019-3

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83 of 83 references verified0 citation errors · 0 not checkable

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  • Selective activation of D1R disrupts several kinds of reward and incentive learning and may disrupt learning of associations between the social reward provided by the partner and the partner's specific identity cues.

    “Selective activation of D1R also disrupts several kinds of reward and incentive learning (Beninger et al 1989) and therefore may disrupt the learning of associations between the social reward provided by the partner, and the partner’s specific identity cues.”
  • Activation of D2R in the nucleus accumbens shell is rewarding and enhances reward-based learning, which aligns with the role of D2R in pair bonding.

    “Meanwhile, activation of D2R in the NAC shell is rewarding and enhances reward-based learning (Beninger et al 1989), which aligns well with the role of D2R in pair bonding.”

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Authors
Beninger, R. J., Hoffman, D. C., & Mazurski, E. J.
Affiliations
Queen's University (CA)
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1989-06
Volume
13
Issue
2-3
Pages
113-122
ISSN
0149-7634 (ISSN-L)
OpenAlex
W1976403478
Cited by
109
References
89
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 7
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, reward learning, conditioned reward, self-administration, extinction, place preference, amphetamine, dopamine release
MeSH terms
Animals, Avoidance Learning, Conditioning, Psychological, Receptors, Dopamine, Reward, Self Administration, Dopamine Agents, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Antagonists

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