Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus
Abstract
Samples of the hippocampus of four patients with Down's syndrome [two men aged 35 and 36 years with no evidence of Alzheimer's disease (AD) and two patients aged 47 and 55 years with associated AD] were obtained at post mortem and processed according to the rapid Golgi method. A significant reduction in the number of dendritic spines (DS) was found in the apical (middle, distal and oblique segments) and basilar (thick and thin segments) dendritic arbors of CA1 and CA2-3 pyramidal neurons in patients with Down's syndrome and no AD when compared to age-matched controls. An additional decrease of DS in every segment occurred in Down's patients with associated AD when compared to age-matched controls and Down's patients with no AD. In Down's syndrome (either associated or not to AD) thin basilar dendrites were the most severely involved; in AD patients CA1 pyramids were more severely affected than pyramidal neurons of the CA2-3 subfield.
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A decreased number of dendritic spines on pyramidal neurons were found in middle aged adults (47-55 years) with Down syndrome compared to age matched controls.
“and middle aged adults (47–55 years) compared to age matched controls (Ferrer and Gullotta, 1990).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Ferrer and Gullotta, 1990
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- Authors
- Ferrer, I., & Gullotta, F.
- Affiliations
- Universitat de Barcelona (ES)
- University of Münster (DE)
- ORCID
- Ferrer, I.
- Venue
- Acta Neuropathologica
- Published
- 1990-04
- Volume
- 79
- Issue
- 6
- Pages
- 680-685
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2072480165
- Cited by
- 201
- References
- 1
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 5 · 2013: 15 · 2012: 9
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome, Alzheimer's disease, dendritic spines, hippocampus, CA1 pyramidal neurons, Golgi staining, postmortem brain
- MeSH terms
- Adult, Alzheimer Disease, Cell Count, Dendrites, Down Syndrome, Female, Hippocampus, Humans, Male, Middle Aged
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