Dendritic atrophy in children with down’s syndrome.
Abstract
Dendritic branching was evaluated in the visual cortex of 8 children with Down's syndrome and 10 controls, ranging in age from 4 months to 7 years and divided into infantile, late-infantile, and juvenile groups. Camera lucida drawings of Golgi-impregnated neurons were used for examining the following dendritic aspects: dendritic intersections as a function of distance from the cell body, point of maximum dendritic branching, number of branch orders, total number of branch segments, and total dendritic length. The number of intersections and the total dendritic length were above normal in the infantile period (6 months old or less) and dropped steadily to significantly below normal in the juvenile group (older than 2 years). These reductions contrasted with expanding dendritic arborization in normal children. The results suggest that the dendritic tree atrophies in early childhood in Down's syndrome.
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In infants aged 0-6 months, the total dendritic length was longer in samples from individuals with Down syndrome compared to controls.
“Initially, in infants aged 0–6 months, the total dendritic length was longer in samples from individuals with DS compared to controls.”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
As development continued, dendritic length became significantly shorter in samples from individuals with Down syndrome and persisted at least into childhood (7 years).
“However, as development continued this difference reversed, with dendritic length becoming significantly shorter in samples from individuals with DS and persisting at least into childhood (7 years) (Becker et al., 1986).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
Human equivalent age of engrafted neurons (5-8 months) is comparable to samples showing increased spine number in human tissue.
“However, the human equivalent age of the engrafted neurons (5–8 months) during this time period is comparable to the samples that show an increase spine number in human tissue (Becker et al., 1986).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986
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Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome
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- Authors
- Becker, L. E., Armstrong, D. L., & Chan, F.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Becker, L. E.
- ORCID
- Becker, L. E.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1986-10
- Volume
- 20
- Issue
- 4
- Pages
- 520-526
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2137900611
- Cited by
- 279
- References
- 25
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 14 · 2012: 16
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- Down syndrome, dendritic atrophy, dendritic branching, visual cortex, dendritic length, children
- MeSH terms
- Child, Preschool, Dendrites, Down Syndrome, Humans, Infant, Visual Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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