Cited by 279Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersWilliams Syndrome Research

Dendritic atrophy in children with down’s syndrome.

Becker, L. E., Armstrong, D. L., Chan, F.·1986·Annals of Neurology

Abstract

Dendritic branching was evaluated in the visual cortex of 8 children with Down's syndrome and 10 controls, ranging in age from 4 months to 7 years and divided into infantile, late-infantile, and juvenile groups. Camera lucida drawings of Golgi-impregnated neurons were used for examining the following dendritic aspects: dendritic intersections as a function of distance from the cell body, point of maximum dendritic branching, number of branch orders, total number of branch segments, and total dendritic length. The number of intersections and the total dendritic length were above normal in the infantile period (6 months old or less) and dropped steadily to significantly below normal in the juvenile group (older than 2 years). These reductions contrasted with expanding dendritic arborization in normal children. The results suggest that the dendritic tree atrophies in early childhood in Down's syndrome.

Integrity signals

Registry

Crossref · 10.1002/ana.410200413

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In infants aged 0-6 months, the total dendritic length was longer in samples from individuals with Down syndrome compared to controls.

    “Initially, in infants aged 0–6 months, the total dendritic length was longer in samples from individuals with DS compared to controls.”

    From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986

  • As development continued, dendritic length became significantly shorter in samples from individuals with Down syndrome and persisted at least into childhood (7 years).

    “However, as development continued this difference reversed, with dendritic length becoming significantly shorter in samples from individuals with DS and persisting at least into childhood (7 years) (Becker et al., 1986).”

    From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986

  • Human equivalent age of engrafted neurons (5-8 months) is comparable to samples showing increased spine number in human tissue.

    “However, the human equivalent age of the engrafted neurons (5–8 months) during this time period is comparable to the samples that show an increase spine number in human tissue (Becker et al., 1986).”

    From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Becker et al., 1986

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Becker, L. E., Armstrong, D. L., & Chan, F.
Affiliations
University of Toronto (CA)
Corresponding author
Becker, L. E.
Venue
Annals of Neurology
Publisher
Wiley
Published
1986-10
Volume
20
Issue
4
Pages
520-526
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2137900611
Cited by
279
References
25
Citations by year
2026: 1 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 14 · 2012: 16
FWCI
5.85
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords
Down syndrome, dendritic atrophy, dendritic branching, visual cortex, dendritic length, children
MeSH terms
Child, Preschool, Dendrites, Down Syndrome, Humans, Infant, Visual Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review