A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population
Open accessAbstract
A cross-sectional multicentre study of randomly selected diabetic patients was performed using a standardised questionnaire and examination, to establish the prevalence of peripheral neuropathy in patients attending 118 hospital diabetes clinics in the UK. Vibration perception threshold was performed in two centres to compare with the clinical scoring systems. A total of 6487 diabetic patients were studied. 53.9% male, median age 59 years (range 18-90 years). 37.4% Type 1 (insulin-dependent) diabetes mellitus, with a median duration of diabetes 8 years (0-62 years). The overall prevalence of neuropathy was 28.5% (27.4-29.6%) (95% confidence interval) in this population. The prevalence in Type 1 diabetic patients was 22.7% (21.0-24.4%) and in Type 2 (non-insulin-dependent) diabetic patients it was 32.1% (30.6-33.6%). The prevalence of diabetic peripheral neuropathy increased with age, from 5% (3.1-6.9%) in the 20-29 year age group to 44.2% (41.1-47.3%) in the 70-79 year age group. Neuropathy was associated with duration of diabetes, and was present in 20.8% (19.1-22.5%) of patients with diabetes duration less than 5 years and in 36.8% (34.9-38.7%) of those with diabetes duration greater than 10 years. Mean vibration perception threshold measured at the great toe was 21.1 +/- 13.5 SD volts and correlated with the neuropathy disability score, r = 0.8 p < 0.001. In conclusion, diabetic peripheral neuropathy is a common complication associated with diabetes. It increases with both age and duration of diabetes, until it is present in more than 50% of Type 2 diabetic patients aged over 60 years.(ABSTRACT TRUNCATED AT 250 WORDS)
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Diabetic peripheral polyneuropathy affects 50% of patients with diabetes.
“Diabetic peripheral polyneuropathy (also known as diabetic neuropathy) affects 50% of patients with diabetes [3–5]”
From A Consideration of the Psychological Aspects to Managing Patients with Painful Diabetic Neuropathy: An Insight into Pain Management Services at a Tertiary Centre in the UK (2021) · cites this paper as [5]
The Prevalence data section reports 28.5% among the UK hospital-clinic patients studied, not 50%. The Discussion says prevalence exceeds 50% only for Type 2 patients over age 60 attending a hospital clinic; the claim omits that restriction. (LLM, conf=0.90)
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Experimental — accuracy not yet measuredIn BARI 2D, participants-especially men-treated with insulin sensitizers had a lower 4-year incidence of DPN than those given insulin or sulfonylureas.
“For example, participants, particularly men, in the BARI 2D trial treated with insulin sensitizers had a lower incidence of DPN over 4 years than those treated with insulin/SUs.570”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [570]
The Subjects and methods and Prevalence data sections describe a cross-sectional survey of UK hospital-clinic patients, not a four-year treatment comparison. Searches for BARI 2D, insulin sensitizers, and four-year neuropathy incidence found no passage addressing the attributed result. Page numbers were not available in our copy. (LLM, conf=0.78)
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- Authors
- Young, M. J., Boulton, A. J. M., Macleod, A. F., Williams, D. R. R., & Sonksen, P. H.
- Affiliations
- Manchester Royal Infirmary (GB)
- St Thomas' Hospital (GB)
- Addenbrooke's Hospital (GB)
- Venue
- Diabetologia
- Published
- 1993-02
- Volume
- 36
- Issue
- 2
- Pages
- 150-154
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1984637736
- Cited by
- 1,502
- References
- 25
- Citations by year
- 2026: 36 · 2025: 51 · 2024: 50 · 2023: 59 · 2022: 77 · 2021: 84 · 2020: 78 · 2019: 70 · 2018: 72 · 2017: 67 · 2016: 61 · 2015: 71 · 2014: 60 · 2013: 65 · 2012: 56
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- diabetic peripheral neuropathy, prevalence, type 1 diabetes, type 2 diabetes, vibration perception threshold, neuropathy disability score, diabetes duration, age-related risk
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Female, United Kingdom, Humans, Male, Middle Aged, Outpatient Clinics, Hospital, Surveys and Questionnaires, Regression Analysis, Prevalence, Foot Ulcer
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