Diabetic neuropathy

Vinik, Aaron I.; Nevoret, Marie-Laure; Casellini, Carolina; Parson, Henri

doi:10.1016/j.ecl.2013.06.001

Cited by 373Pain Mechanisms and TreatmentsPeripheral Neuropathies and DisordersAldose Reductase and Taurine

Diabetic neuropathy

Vinik, Aaron I., Nevoret, Marie-Laure, Casellini, Carolina, Parson, Henri·2013·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.06.001

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Abstract

Diabetic neuropathy (DN) is the most common and troublesome complication of diabetes mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care. The clinical assessment of diabetic peripheral neuropathy and its treatment options are multifactorial. Patients with DN should be screened for autonomic neuropathy, as there is a high degree of coexistence of the two complications. A review of the clinical assessment and treatment algorithms for diabetic neuropathy, painful neuropathy, and autonomic dysfunction is provided.

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The true prevalence of diabetic neuropathy is unclear but it varies from 10 to 90% in diabetics, according to the different standards and approaches used to define diabetic neuropathy.
“The true prevalence is unclear but it varies from 10 to 90% in diabetics, according to the different standards and approaches used to define diabetic neuropathy (107).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [107]
Neuropathy is associated with a 1.7-fold increase in the risk of amputation, and even higher when coupled with other problems.
“It has been reported that neuropathy is associated with a 1.7-fold increase in the risk of amputation, and even higher when coupled with other problems (107).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [107]

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de Valk (1998) · doi:10.1002/(sici)1096-9136(199806)15:6

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New Techniques for the Evaluation of Diabetic Neuropathies
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Self-citation
Diagnosis and Management of Diabetic Neuropathy
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Peripheral nerves in diabetic neuropathy: Features and methods
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An update on the diagnosis and treatment of diabetic somatic and autonomic neuropathy
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Diabetic Peripheral Neuropathy: New Diagnostics and Treatment Perspectives
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Authors: Vinik, A. I., Nevoret, M.-L., Casellini, C., & Parson, H.
Affiliations: Eastern Virginia Medical School (US)
Corresponding author: Vinik, Aaron I.
ORCID: Vinik, Aaron I.
Casellini, Carolina
Parson, Henri
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2013-12
Volume: 42
Issue: 4
Pages: 747-787
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.06.001
OpenAlex: W4210977503
Cited by: 366
References: 181
Citations by year: 2026: 30 · 2025: 36 · 2024: 42 · 2023: 38 · 2022: 40 · 2021: 36 · 2020: 41 · 2019: 27 · 2018: 12 · 2017: 16 · 2016: 17 · 2015: 15 · 2014: 16
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: diabetic neuropathy, diabetic peripheral neuropathy, autonomic neuropathy, diabetic neuropathic pain, autonomic dysfunction, diabetes complications, neuropathy screening, clinical evaluation
MeSH terms: Autonomic Nervous System Diseases, Cardiovascular Diseases, Diabetic Neuropathies, Humans, Hyperglycemia, Neuralgia, Guidelines as Topic

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