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Cited by 162Diabetes Management and ResearchClinical Laboratory Practices and Quality ControlPancreatic function and diabetes

Arterial, arterialized venous, venous and capillary blood glucose measurements in normal man during hyperinsulinaemic euglycaemia and hypoglycaemia

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Liu, D., Moberg, E., Kollind, M., Lins, P. -E., Adamson, U., Macdonald, I. A.·1992·Diabetologia
DOI 10.1007/bf00400932
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Abstract

The purpose of this study was to evaluate the effectiveness of the warm-air box method on the arterialization of venous blood during euglycaemia and hypoglycaemia. Six healthy male volunteers were studied using an i.v. infusion of insulin (144 mU.kg-1.h-1). Arterial blood glucose was clamped at the baseline level for the first 30 min and subsequently reduced to 3.2 and to 2.5 mmol/lf or 20 min. At each stage, including prior to insulin infusion, arterial, arterialized venous (heating the hand in a warm-air box set to 55-60 degrees C), venous and capillary blood samples were taken simultaneously for analyses of blood glucose and oxygen saturation (not for capillary blood). The oxygen saturations in arterialized blood were approximately 3% below the arterial values. The arterial-arterialized difference of blood glucose was about 0.1 mmol/l (the 95% confidence interval: from -0.19 to 0.41 mmol/l), which tended to correlate with the difference in oxygen saturations between the arterial and arterialized blood samples (r = 0.25, p = 0.08). During the test the forearm venous blood oxygen saturation increased by 9% and the arteriovenous difference in blood glucose ranged from 0.2 to 0.5 mmol/l which correlated significantly with the difference in oxygen saturations (r = 0.48, p less than 0.001). Capillary glucose was similar to the arterialized value. Rectal temperature was stable during the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • In the hypoglycaemic range, the arteriovenous difference is small (probably less than 0.2 mmol/l), but it can be influenced considerably by the level and duration of hyperinsulinaemia.

    “In the hypoglycaemic range the arteriovenous difference is small (probably less than 0.2 mmol/l), but it can be influenced considerably by the level and duration of hyperinsulinaemia [8].”

    From Defining hypoglycaemia: what level has clinical relevance? (2009) · cites this paper as [7]

  • Plasma glucose derived from arterialised venous blood is higher (about 15%) than glucose measured in capillary or venous whole blood.

    “The plasma glucose concentration derived from arterialised venous blood is higher (about 15%) than glucose measured in capillary or venous whole blood [7].”

    From Defining hypoglycaemia: what level has clinical relevance? (2009) · cites this paper as [7]

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Authors
Liu, D., Moberg, E., Kollind, M., Lins, P. E., Adamson, U., & Macdonald, I. A.
Affiliations
  • Danderyds sjukhus (SE)
  • University of Nottingham (GB)
ORCID
Macdonald, I. A.
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
1992-03
Volume
35
Issue
3
Pages
287-290
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/bf00400932
OpenAlex
W2138605610
Cited by
162
References
5
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 10 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
4.96
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Karolinska Institutet
  • Svenska Läkaresällskapet
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
capillary blood glucose, arterial blood glucose, hypoglycemia, arteriovenous glucose difference, vasodilation, insulin infusion
MeSH terms
Adult, Analysis of Variance, Arteries, Blood Glucose, Capillaries, Humans, Hyperinsulinism, Hypoglycemia, Insulin, Male, Oxygen, Reference Values, Veins, Glucose Clamp Technique

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